| Insider Shares | 786,266,474 shares |
| Total Insiders | 41 |
Insider Sentiment Score
The Insider Sentiment Score finds the companies being bought by corporate insiders.
It is the result of a sophisticated, multi-factor quantitative model that identifies companies with the highest levels of insider accumulation. The scoring model uses a combination of the net number of insiders buying the prior 90 days, the total shares bought as a percentage of float, and the total shares owned by insiders. The number ranges from 0 to 100, with higher numbers indicating a higher level of accumulation to its peers, and 50 being the average.
Update Frequency: Daily
See Insiders Top Picks, which provides a list of companies with highest insider accumulation.
Officer Sentiment Score
The Officer Sentiment Score finds companies being bought by Corporate Officers.
By definition Corporate Officers are Corporate Insiders, but unlike some of the other Insiders (10% Shareholders and Board Members), Officers work for the company on a daily basis, and they user their own money when trading. (10% Shareholders and Board Members are often fund managers managing other people’s money.) As such, insider trades made by Officers are much more significant and should be treated appropriately.
Like the Insider Sentiment Score, the Officer Sentiment Score is the result of a sophisticated, multi-factor quantitative model that identifies companies with the highest levels of officer accumulation.
Update Frequency: Daily
See Insiders Top Picks, which provides a list of companies with highest insider sentiment.
Key Insider Metrics
This card shows how the company ranks along various insider metrics. The percentile rank shows how this company compares to other companies in the US markets. Higher rankings are indicative of better situations.
For example, it is generally accepted that insider buying is a positive indicator, so companies with more insider buying would rank higher than companies with less insider buying (or even insider selling).
Percent of Float Bought by Insiders (Rank)
N/A
Percent of Float Bought by Insiders is the total number of shares purchased by insiders minus the total number of shares sold by insiders in the last 90 days, divided by the total float and multiplied by 100.
Insider Trading Chart
Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock) insider trades are shown in the following chart. Insiders are officers, directors, or significant investors in a company. In general, it is generally illegal for insiders to make trades in their companies based on material, non-public information. This does not mean it is illegal for them to make any trades in their own companies. However, they must report all trades to the SEC via a Form 4.
Insider Roster and Profitability Metrics
This table shows the list known insiders, and is generated automatically from filings disclosed to the SEC. In addition to the names, most recent title, and director, officer, or 10% owner designation, we provide the latest disclosed holdings. Additionally, when possible we provide the historical trade performance for the insider. The historical trade performance is a weighted average of the performance of actual open-market purchase transactions made by the insider. For more information on how this is calculated, watch this YouTube webinar.
See our leaderboard of most profitable insider traders.
| Insider | Avg Profit (%) | Shares Owned |
Split Adjusted |
|---|---|---|---|
| Lawrence M Alleva Director - [D] | 12,600 | 12,600 | |
| Rafael Amado President, R&D - [O] | 17,237 | 17,237 | |
|
M James Barrett
10% Owner -
|
82,978,668 | 82,978,668 | |
|
Peter J Barris
10% Owner -
|
12,000,000 | 12,000,000 | |
|
Forest Baskett
10% Owner -
|
19,500,000 | 19,500,000 | |
| Ali Behbahani Director - [D] | 0 | 0 | |
| William C JR Bertrand Chief Operating Officer - [O] | 986,352 | 986,352 | |
| Gwendolyn Knowlton Binder-Scholl Chief Technology Officer - [O] | 2,487 | 2,487 | |
| Joanna Elizabeth Brewer | 223,512 | ||
| Barbara Gayle Duncan | 144,000 | ||
|
EcoR1 Capital, LLC
10% Owner -
|
100,371,882 | 100,371,882 | |
|
Florence Anthony A. Jr.
10% Owner -
|
19,500,000 | 19,500,000 | |
| John Furey | 196,186 |
| Insider | Avg Profit (%) | Shares Owned |
Split Adjusted |
|---|---|---|---|
| Michael Garone | 0 | ||
| Samuel D Isaly Director - [D] | 6,149,377 | 6,149,377 | |
|
Patrick J Kerins
10% Owner -
|
82,978,668 | 82,978,668 | |
|
Krishna Kittu Kolluri
10% Owner -
|
118,538,000 | 118,538,000 | |
| Giles Francis Bertram Kerr | 124,000 | ||
| Jonathan Kenneth Charles Knowles Director - [D] | 7,208,768 | 7,208,768 | |
| Ian Michael Laing Director - [D] | 58,085,600 | 58,085,600 | |
| John Lunger Chief Patient Supply Officer - [O] | 7,510 | 7,510 | |
|
David M Mott
Director, 10% Owner -
[D]
|
19,500,000 | 19,500,000 | |
| Garry E Menzel Director - [D] | 75,056 | 75,056 | |
|
Nea 14 Gp, Ltd
10% Owner -
|
82,978,668 | 82,978,668 | |
|
NEA Partners 14, L.P.
10% Owner -
|
82,978,668 | 82,978,668 | |
|
New Enterprise Associates 14, L.P.
10% Owner -
|
82,978,668 | 82,978,668 | |
| James Noble Director - [D] | 0 | 0 |
| Insider | Avg Profit (%) | Shares Owned |
Split Adjusted |
|---|---|---|---|
| Elliot Norry Chief Medical Officer - [O] | 7,510 | 7,510 | |
| Orbimed Advisors Llc Director - [D] | 4,901,310 | 4,901,310 | |
| OrbiMed Capital GP V LLC Director - [D] | 4,901,310 | 4,901,310 | |
| Cintia Piccina Chief Commercial Officer - [O] | 18,421 | 18,421 | |
| Adrian Rawcliffe Chief Executive Officer, Director - [D] [O] | 44,327 | 44,327 | |
|
Scott D Sandell
10% Owner -
|
19,500,000 | 19,500,000 | |
| Charles Elliott Sigal Director - [D] | 314,100 | 314,100 | |
|
Sonsini Peter W.
10% Owner -
|
19,500,000 | 19,500,000 | |
| Helen Katrina Tayton-martin Chief Business Officer - [O] | 1,800,000 | 1,800,000 | |
| Thompson Peter A. Director - [D] | 4,901,310 | 4,901,310 | |
|
Ravi Viswanathan
10% Owner -
|
12,000,000 | 12,000,000 | |
|
Harry R Weller
10% Owner -
|
118,538,000 | 118,538,000 | |
| Gavin Wood Chief Financial Officer - [O] | 0 | 0 | |
| Tal Zvi Zaks | 144,000 |
Report errors via our new Insider Auditing Tool
Track Records of Insider Purchases - Short Term Profit Analysis
In this section, we analyze the profitability of every unplanned, open-market insider purchase made in ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock). This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical .
The following table shows the most recent open market purchases that were not part of an automatic trading plan.
Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.
Track Records of Insider Sales - Short Term Loss Analysis
In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock). A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical .
The following table shows the most recent open market sales that were not part of an automatic trading plan.
Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.
Transaction History
Click the link icon to see the full transaction history. Transactions reported as part of a 10b5-1 automatic trading plan will have an X in the column marked 10b-5.
| File Date |
Trade Date |
Form | Insider | Ticker | Security Title | Code | Direct | Exercise Price |
Unit Price |
Units Changed |
Value Changed (1K) |
Remaining Options |
Remaining Shares |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-09-03 | 2025-09-02 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.0099 | -96,000 | -1 | 0 | ||||
| 2025-08-29 | 2025-08-28 | 4 | Bertrand William C JR | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.0101 | -207,000 | -2 | 986,352 | ||||
| 2025-08-19 | 2025-08-18 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.0120 | -14,671,794 | -176 | 0 | ||||
| 2025-08-19 | 2025-08-15 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.0110 | -4,828,206 | -53 | 14,671,794 | ||||
| 2025-07-30 | 2025-07-30 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 0.1021 | -27,433,338 | -2,801 | 100,371,882 | ||||
| 2025-07-30 | 2025-07-29 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 0.1012 | -2,687,460 | -272 | 127,805,220 | ||||
| 2025-07-30 | 2025-07-28 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 0.1125 | -33,931,740 | -3,817 | 130,492,680 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5808 | -5,584 | -3 | 7,510 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5808 | -5,584 | -3 | 7,510 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5808 | -5,584 | -3 | 7,510 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5808 | -30,601 | -18 | 44,327 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5748 | -12,991 | -7 | 18,421 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5748 | -29,096 | -17 | 41,582 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -17,934 | -11 | 25,711 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -12,539 | -7 | 17,801 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5748 | -9,803 | -6 | 13,756 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -8,124 | -5 | 11,516 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -4,268 | -3 | 5,845 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5748 | -9,803 | -6 | 13,756 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -5,471 | -3 | 7,623 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -4,268 | -3 | 5,845 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5748 | -9,803 | -6 | 13,756 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -5,471 | -3 | 7,623 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.5879 | -4,268 | -3 | 5,845 | ||||
| 2024-06-18 | 2024-06-18 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.9300 | -24,531 | -23 | 38,293 | ||||
| 2024-03-26 | 3 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 164,424,420 | ||||||||
| 2024-01-17 | 2024-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -30,080 | -20 | 44,848 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.7900 | -9,304 | -7 | 14,104 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -12,967 | -9 | 19,257 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -5,309 | -4 | 7,785 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.7900 | -2,287 | -2 | 3,363 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -12,805 | -9 | 19,015 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -5,309 | -4 | 7,785 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.7900 | -4,681 | -4 | 7,023 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -13,599 | -9 | 20,201 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.6730 | -5,309 | -4 | 7,785 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.7900 | -4,681 | -4 | 7,023 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8541 | -5,220 | -4 | 7,874 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8367 | -4,009 | -3 | 6,104 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8541 | -17,257 | -15 | 26,388 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8367 | -11,945 | -10 | 18,395 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8541 | -5,220 | -4 | 7,874 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8367 | -4,009 | -3 | 6,104 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8541 | -7,799 | -7 | 11,841 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.8367 | -4,009 | -3 | 6,104 | ||||
| 2023-09-01 | 2023-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.7800 | -2,403 | -2 | 3,449 | ||||
| 2023-08-01 | 2023-08-01 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.9056 | -3,096 | -3 | 4,718 | ||||
| 2023-07-10 | 2023-07-10 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.9108 | -47,702 | -43 | 75,056 | ||||
| 2023-06-27 | 2023-06-27 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0.9200 | -2,333 | -2 | 3,519 | ||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | D | 209,931 | 209,931 | ||||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | I | 200,647 | 200,647 | ||||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | I | 200,646 | 200,646 | ||||||
| 2023-01-31 | 2023-01-31 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.8696 | -11,890 | -22 | 19,535 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.8580 | -4,440 | -8 | 7,264 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.8580 | -10,057 | -19 | 13,351 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.8580 | -4,440 | -8 | 7,264 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.8580 | -2,159 | -4 | 3,491 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7060 | -4,973 | -8 | 8,121 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7468 | -3,843 | -7 | 6,270 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7060 | -4,973 | -8 | 8,121 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7468 | -3,843 | -7 | 6,270 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7060 | -7,449 | -13 | 12,191 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7468 | -3,843 | -7 | 6,270 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7060 | -18,763 | -32 | 24,882 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7468 | -13,042 | -23 | 17,298 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6940 | -3,584 | -6 | 5,781 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6940 | -5,073 | -9 | 6,631 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6940 | -876 | -1 | 1,361 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6940 | -1,100 | -2 | 1,725 | ||||
| 2022-09-01 | 2022-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.9689 | -2,536 | -5 | 3,316 | ||||
| 2022-08-01 | 2022-08-01 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7735 | -2,983 | -5 | 4,829 | ||||
| 2022-08-01 | 2022-08-01 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.7735 | -21,040 | -37 | 34,824 | ||||
| 2022-07-05 | 2022-07-05 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6781 | -1,973 | -3 | 3,104 | ||||
| 2022-06-27 | 2022-06-27 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.6300 | -2,562 | -4 | 3,290 | ||||
| 2022-05-23 | 2022-05-20 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.2904 | 39,000 | 11 | 96,000 | ||||
| 2022-05-04 | 2022-05-04 | 4 | Brewer Joanna Elizabeth | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 223,512 | 223,512 | |||||
| 2022-05-04 | 2022-05-04 | 4 | Brewer Joanna Elizabeth | ADAP | Option to purchase Ordinary Shares | D | 0.30 | 333,792 | 333,792 | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 335,184 | 335,184 | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 754,200 | 754,200 | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | 0.45 | 3,376,992 | 3,376,992 | |||||
| 2022-01-18 | 2022-01-18 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.1918 | -4,368 | -14 | 7,336 | ||||
| 2022-01-18 | 2022-01-18 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.1918 | -4,368 | -14 | 7,336 | ||||
| 2022-01-18 | 2022-01-18 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.1918 | -2,121 | -7 | 3,529 | ||||
| 2022-01-18 | 2022-01-18 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.1918 | -11,096 | -35 | 12,312 | ||||
| 2022-01-13 | 2022-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 314,256 | 314,256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 1,407,072 | 1,407,072 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 314,256 | 314,256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 1,407,072 | 1,407,072 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5441 | -2,248 | -8 | 3,754 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5567 | -3,770 | -13 | 6,343 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 314,256 | 314,256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 1,407,072 | 1,407,072 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5441 | -1,076 | -4 | 1,749 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5567 | -3,770 | -13 | 6,343 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5441 | -854 | -3 | 1,383 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5567 | -3,770 | -13 | 6,343 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5441 | -3,046 | -11 | 3,356 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5567 | -14,362 | -51 | 15,978 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 471,360 | 471,360 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 2,110,608 | 2,110,608 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 1,047,480 | 1,047,480 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 4,690,224 | 4,690,224 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 314,256 | 314,256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.60 | 1,407,072 | 1,407,072 | |||||
| 2022-01-05 | 2022-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.0642 | -3,490 | -14 | 5,873 | ||||
| 2022-01-05 | 2022-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.0642 | -1,070 | -4 | 1,755 | ||||
| 2022-01-05 | 2022-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.0642 | -849 | -3 | 1,388 | ||||
| 2022-01-05 | 2022-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.0642 | -5,532 | -22 | 6,172 | ||||
| 2021-09-01 | 2021-09-01 | 4 | Rawcliffe Adrian | ADAP] | American Depositary Shares representing Ordinary Shares | D | 5.1950 | -2,782 | -14 | 3,070 | ||||
| 2021-08-02 | 2021-08-02 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3.5848 | -2,939 | -11 | 4,873 | ||||
| 2021-07-02 | 2021-07-01 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 379,788 | 379,788 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 505,918 | 505,918 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 474,385 | 474,385 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 474,385 | 474,385 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 379,788 | 379,788 | |||||
| 2021-07-02 | 2021-07-02 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.2649 | -4,375 | -19 | 7,329 | ||||
| 2021-07-02 | 2021-07-01 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 579,494 | 579,494 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 379,788 | 379,788 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | 0.71 | 379,788 | 379,788 | |||||
| 2021-07-02 | 2021-07-02 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.2649 | -1,907 | -8 | 3,170 | ||||
| 2021-06-28 | 2021-06-28 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 4.3700 | -2,794 | -12 | 3,058 | ||||
| 2021-06-03 | 2021-06-01 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 0.7900 | 12,600 | 10 | 12,600 | ||||
| 2021-03-03 | 2021-03-03 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.1570 | 1,785,000 | 280 | 1,800,000 | ||||
| 2021-01-19 | 2021-01-19 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.6695 | -2,111 | -12 | 3,539 | ||||
| 2021-01-19 | 2021-01-19 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.6695 | -4,358 | -25 | 7,346 | ||||
| 2021-01-19 | 2021-01-19 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.6695 | -9,879 | -56 | 13,529 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 6.1522 | -2,234 | -14 | 3,768 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 6.1522 | -1,058 | -7 | 1,767 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 6.1522 | -841 | -5 | 1,396 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 6.1522 | -2,707 | -17 | 3,695 | ||||
| 2021-01-11 | 2021-01-11 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 242,712 | 242,712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 1,086,816 | 1,086,816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 242,712 | 242,712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 1,086,816 | 1,086,816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 728,160 | 728,160 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 3,260,400 | 3,260,400 | |||||
| 2021-01-11 | 2021-01-11 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 242,712 | 242,712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 1,086,816 | 1,086,816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 242,712 | 242,712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 1,086,816 | 1,086,816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 242,712 | 242,712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 1.03 | 1,086,816 | 1,086,816 | |||||
| 2021-01-05 | 2021-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3279 | -1,065 | -6 | 1,760 | ||||
| 2021-01-05 | 2021-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3279 | -845 | -5 | 1,392 | ||||
| 2021-01-05 | 2021-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3279 | -3,499 | -19 | 5,864 | ||||
| 2021-01-05 | 2021-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3279 | -4,967 | -26 | 6,737 | ||||
| 2020-12-16 | 2020-12-14 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.6896 | 24,000 | 17 | 57,000 | ||||
| 2020-12-15 | 2020-12-14 | 4 | Bertrand William C JR | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.6948 | 207,000 | 144 | 284,808 | ||||
| 2020-09-02 | 2020-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 8.5149 | -2,776 | -24 | 3,076 | ||||
| 2020-08-04 | 2020-08-03 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 9.2500 | -2,788 | -26 | 3,064 | ||||
| 2020-08-04 | 2020-08-03 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | 8.7409 | -200,000 | -1,748 | 0 | ||||
| 2020-08-04 | 2020-08-03 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 9.2500 | -4,823 | -45 | 8,066 | ||||
| 2020-07-01 | 2020-07-01 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 184,258 | 184,258 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 196,186 | 196,186 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 197,678 | 197,678 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 144,000 | 144,000 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 144,000 | 144,000 | |||||
| 2020-07-01 | 2020-07-01 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 226,753 | 226,753 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 184,258 | 184,258 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 1.67 | 179,785 | 179,785 | |||||
| 2020-06-30 | 2020-06-29 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 1.6200 | 33,000 | 53 | 33,000 | ||||
| 2020-06-11 | 2020-06-09 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1.8900 | 12,900 | 24 | 12,900 | ||||
| 2020-06-02 | 2020-05-29 | 4 | Noble James | ADAP | American Depositary Shares | D | 9.3320 | -500,000 | -4,666 | 0 | ||||
| 2020-04-01 | 2020-04-01 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 565,000 | 565,000 | |||||
| 2020-04-01 | 2020-04-01 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0.45 | 2,500,000 | 2,500,000 | |||||
| 2020-04-01 | 2020-04-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.45 | 31,000 | 31,000 | |||||
| 2020-01-28 | 2020-01-24 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.6667 | 7,500,000 | 5,000 | 19,500,000 | ||||
| 2020-01-17 | 2020-01-16 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 135,600 | 135,600 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0.74 | 201,600 | 201,600 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 280,896 | 280,896 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.74 | 1,257,744 | 1,257,744 | |||||
| 2020-01-17 | 2020-01-16 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 280,896 | 280,896 | |||||
| 2020-01-17 | 2020-01-16 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.74 | 1,257,744 | 1,257,744 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 561,792 | 561,792 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.74 | 2,515,536 | 2,515,536 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 280,896 | 280,896 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.74 | 1,257,744 | 1,257,744 | |||||
| 2020-01-15 | 2020-01-13 | 4 | Noble James | ADAP | American Depositary Shares | D | 5.0000 | -200,000 | -1,000 | 0 | ||||
| 2020-01-15 | 2020-01-13 | 4 | Noble James | ADAP | American Depositary Shares | D | 4.0000 | -100,000 | -400 | 0 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.1347 | -3,236 | -17 | 3,166 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.1347 | -1,144 | -6 | 1,681 | ||||
| 2020-01-15 | 2020-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | 5.0000 | -50,000 | -250 | 0 | ||||
| 2020-01-15 | 2020-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | 4.0000 | -50,000 | -200 | 0 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.1347 | -2,397 | -12 | 3,605 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.1347 | -911 | -5 | 1,326 | ||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 5,358 | ||||||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 5,358 | ||||||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 5,358 | ||||||||
| 2020-01-07 | 2020-01-06 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.2000 | -5,900 | -7 | 5,804 | ||||
| 2020-01-07 | 2020-01-06 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.2000 | -3,731 | -4 | 5,632 | ||||
| 2020-01-07 | 2020-01-06 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1.2000 | -1,148 | -1 | 1,677 | ||||
| 2019-09-03 | 2019-09-01 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 140,448 | 140,448 | |||||
| 2019-09-03 | 2019-09-01 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.27 | 628,872 | 628,872 | |||||
| 2019-08-07 | 2019-08-06 | 4 | Amado Rafael | ADAP | American Depositary Shares representing Ordinary Shares | D | 2.0600 | -11,043 | -23 | 17,237 | ||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 57,612 | ||||||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 57,612 | ||||||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 57,612 | ||||||||
| 2019-08-05 | 2019-08-01 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 187,500 | 187,500 | |||||
| 2019-08-05 | 2019-08-01 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0.55 | 839,568 | 839,568 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 234,407 | 234,407 | |||||
| 2019-07-03 | 2019-07-02 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 350,947 | 350,947 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 271,209 | 271,209 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 124,000 | 124,000 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 234,407 | 234,407 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 124,000 | 124,000 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 240,541 | 240,541 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0.61 | 124,000 | 124,000 | |||||
| 2019-06-27 | 2019-06-27 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 140,448 | 140,448 | |||||
| 2019-06-27 | 2019-06-27 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.68 | 628,872 | 628,872 | |||||
| 2019-05-17 | 2019-05-16 | 4 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0.1430 | 1,773,100 | 254 | 1,773,100 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3694 | -3,084 | -17 | 3,318 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Amado Rafael | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3694 | -3,028 | -16 | 4,974 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3694 | -2,271 | -12 | 3,731 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares representing Ordinary Shares | D | 5.3694 | -1,514 | -8 | 2,487 | ||||
| 2019-01-08 | 2019-01-04 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 561,792 | 561,792 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.89 | 2,515,536 | 2,515,536 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 224,724 | 224,724 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0.89 | 1,006,224 | 1,006,224 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 280,896 | 280,896 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.89 | 1,257,744 | 1,257,744 | |||||
| 2019-01-08 | 2019-01-04 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 224,724 | 224,724 | |||||
| 2019-01-08 | 2019-01-04 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.89 | 1,006,224 | 1,006,224 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 224,724 | 224,724 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.89 | 1,006,224 | 1,006,224 | |||||
| 2018-12-19 | 2018-12-17 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 0.8400 | 47,280 | 40 | 47,280 | ||||
| 2018-10-02 | 2018-10-01 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares | D | 13.7900 | -25,000 | -345 | 0 | ||||
| 2018-09-10 | 2018-09-07 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRIS PETER J See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BASKETT FOREST See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Florence Anthony A. Jr. See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | MOTT DAVID M See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | SANDELL SCOTT D See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Sonsini Peter W. See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Viswanathan Ravi See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 12,000,000 | 20,000 | 12,000,000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.6667 | 3,000,000 | 5,000 | 82,978,668 | ||||
| 2018-08-31 | 2018-08-29 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares | D | 10.2500 | -25,000 | -256 | 0 | ||||
| 2018-08-07 | 2018-08-06 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 678,720 | 678,720 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 154,809 | 154,809 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 158,233 | 158,233 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 124,000 | 124,000 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 124,000 | 124,000 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 124,000 | 124,000 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 154,809 | 154,809 | |||||
| 2018-06-26 | 2018-06-22 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 2.18 | 187,330 | 187,330 | |||||
| 2018-06-06 | 2018-06-06 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.4900 | -1,600 | -22 | 4,901,310 | ||||
| 2018-06-06 | 2018-06-04 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5700 | -17,100 | -232 | 4,902,910 | ||||
| 2018-06-06 | 2018-06-06 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.4900 | -1,600 | -22 | 4,901,310 | ||||
| 2018-06-06 | 2018-06-04 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5700 | -17,100 | -232 | 4,902,910 | ||||
| 2018-06-01 | 2018-06-01 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.4900 | -50,000 | -674 | 4,920,010 | ||||
| 2018-06-01 | 2018-05-30 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5200 | -121,000 | -1,636 | 4,970,010 | ||||
| 2018-06-01 | 2018-06-01 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.4900 | -50,000 | -674 | 4,920,010 | ||||
| 2018-06-01 | 2018-05-30 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5200 | -121,000 | -1,636 | 4,970,010 | ||||
| 2018-05-16 | 2018-05-14 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5000 | -10,300 | -139 | 5,091,010 | ||||
| 2018-05-16 | 2018-05-14 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13.5000 | -10,300 | -139 | 5,091,010 | ||||
| 2018-03-29 | 2018-03-29 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11.5300 | -31,983 | -369 | 5,101,310 | ||||
| 2018-03-29 | 2018-03-27 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11.5000 | -1,016,084 | -11,685 | 5,133,293 | ||||
| 2018-03-29 | 2018-03-29 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11.5300 | -31,983 | -369 | 5,101,310 | ||||
| 2018-03-29 | 2018-03-27 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11.5000 | -1,016,084 | -11,685 | 5,133,293 | ||||
| 2018-03-28 | 2018-03-27 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9167 | 6,000,000 | 11,500 | 79,978,672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9041 | 571,164 | 1,088 | 73,978,672 | ||||
| 2018-03-23 | 2018-03-23 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9462 | 294,090 | 572 | 73,407,508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.9040 | 869,574 | 1,656 | 73,113,418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1.8105 | 104,844 | 190 | 72,243,844 | ||||
| 2018-03-22 | 2018-03-20 | 4 | Rawcliffe Adrian | ADAP | Ordinary Shares | D | 1.7100 | -600,000 | -1,026 | 0 | ||||
| 2018-01-17 | 2018-01-12 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 384,120 | 384,120 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 1,719,936 | 1,719,936 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 192,060 | 192,060 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 859,968 | 859,968 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 144,048 | 144,048 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 644,976 | 644,976 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 96,036 | 96,036 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 429,984 | 429,984 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 153,648 | 153,648 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 687,984 | 687,984 | |||||
| 2018-01-17 | 2018-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.00 | 153,648 | 153,648 | |||||
| 2018-01-17 | 2018-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 1.30 | 687,984 | 687,984 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 144,000 | 144,000 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 228,765 | 228,765 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 220,788 | 220,788 | |||||
| 2017-07-03 | 2017-07-03 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 302,561 | 302,561 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 243,724 | 243,724 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 144,000 | 144,000 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 220,788 | 220,788 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Thompson Peter A. | ADAP | Option to purchase Ordinary Shares | D | 0.75 | 223,779 | 223,779 | |||||
| 2017-03-28 | 2017-03-27 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 4.2000 | 1,190,476 | 5,000 | 6,149,377 | ||||
| 2017-03-28 | 2017-03-27 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 4.2000 | 1,190,476 | 5,000 | 6,149,377 | ||||
| 2017-03-28 | 2017-03-27 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0.7000 | 12,870,000 | 9,009 | 72,139,000 | ||||
| 2017-01-18 | 2017-01-13 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0.72 | 2,072,976 | 2,072,976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0.72 | 2,072,976 | 2,072,976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0.72 | 2,072,976 | 2,072,976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 0.72 | 2,072,976 | 2,072,976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0.72 | 2,072,976 | 2,072,976 | |||||
| 2016-12-01 | 2016-11-29 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 0.81 | 288,000 | 288,000 | |||||
| 2016-12-01 | 2016-11-29 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0.81 | 288,000 | 288,000 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Thompson Peter A. | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 186,142 | 186,142 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 196,678 | 196,678 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 184,562 | 184,562 | |||||
| 2016-08-12 | 2016-08-11 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 191,410 | 191,410 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Laing Ian Michael | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 144,000 | 144,000 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 184,562 | 184,562 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Knowles Jonathan Kenneth Charles | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 217,222 | 217,222 | |||||
| 2016-05-25 | 2016-05-24 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.4800 | 518,400 | 5,433 | 29,753,404 | ||||
| 2016-05-25 | 2016-05-23 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.4000 | 1,191,600 | 12,393 | 29,235,004 | ||||
| 2016-05-25 | 2016-05-20 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.0400 | 2,400 | 24 | 28,043,404 | ||||
| 2016-05-25 | 2016-05-24 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.4800 | 518,400 | 5,433 | 29,753,404 | ||||
| 2016-05-25 | 2016-05-23 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.4000 | 1,191,600 | 12,393 | 29,235,004 | ||||
| 2016-05-25 | 2016-05-20 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10.0400 | 2,400 | 24 | 28,043,404 | ||||
| 2016-05-19 | 2016-05-19 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1.5600 | 15,000 | 23 | 314,100 | ||||
| 2016-05-18 | 2016-05-18 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1.5500 | 15,000 | 23 | 299,100 | ||||
| 2016-05-18 | 2016-05-17 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1.5300 | 15,000 | 23 | 284,100 | ||||
| 2016-05-18 | 2016-05-16 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1.5000 | 15,000 | 22 | 269,100 | ||||
| 2016-01-20 | 2016-01-18 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 939,948 | 939,948 | |||||
| 2016-01-20 | 2016-01-18 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 704,961 | 704,961 | |||||
| 2016-01-20 | 2016-01-18 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 939,948 | 939,948 | |||||
| 2016-01-20 | 2016-01-18 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 1,968,016 | 1,968,016 | |||||
| 2016-01-20 | 2016-01-18 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 1.27 | 939,948 | 939,948 | |||||
| 2016-01-04 | 3 | Weller Harry R See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Weller Harry R See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Sonsini Peter W. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Sonsini Peter W. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | KOLLURI KRISHNA KITTU See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | KOLLURI KRISHNA KITTU See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Florence Anthony A. Jr. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Florence Anthony A. Jr. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | BARRIS PETER J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | BARRIS PETER J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118,538,000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118,538,000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118,538,000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 561,138 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 561,138 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 359,976 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 359,976 | ||||||||
| 2016-01-04 | 3 | Laing Ian Michael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 58,085,600 | ||||||||
| 2016-01-04 | 3 | Laing Ian Michael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 58,085,600 | ||||||||
| 2016-01-04 | 3 | Alleva Lawrence M | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 141,168 | ||||||||
| 2016-01-04 | 3 | Alleva Lawrence M | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 141,168 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 7,208,768 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 14,205,784 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 7,208,768 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 14,205,784 | ||||||||
| 2016-01-04 | 3 | Amado Rafael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 192,000 | ||||||||
| 2016-01-04 | 3 | Amado Rafael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 192,000 | ||||||||
| 2016-01-04 | 3 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 3,630,000 | ||||||||
| 2016-01-04 | 3 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 3,630,000 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 21,145,200 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 12,372,600 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 21,145,200 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 12,372,600 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | BASKETT FOREST See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | BASKETT FOREST See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | BARRETT M JAMES See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | BARRETT M JAMES See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | MOTT DAVID M See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | MOTT DAVID M See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | KERINS PATRICK J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | KERINS PATRICK J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | SANDELL SCOTT D See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | SANDELL SCOTT D See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53,449,304 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30,673,708 | ||||||||
| 2016-01-04 | 3 | Viswanathan Ravi See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 | ||||||||
| 2016-01-04 | 3 | Viswanathan Ravi See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118,538,000 |
P
Open market or private purchase of non-derivative or derivative security
S
Open market or private sale of non-derivative or derivative security
A
Grant, award, or other acquisition of securities from the company (such as an option)
C
Conversion of derivative
D
Sale or transfer of securities back to the company
F
Payment of exercise price or tax liability using portion of securities received from the company
G
Gift of securities by or to the insider
K
Equity swaps and similar hedging transactions
M
Exercise or conversion of derivative security received from the company (such as an option)
V
A transaction voluntarily reported on Form 4
J
Other (accompanied by a footnote describing the transaction)
