SCYX / SCYNEXIS, Inc. - SEC Filings, Annual Report, Proxy Statement

SCYNEXIS, Inc.
US ˙ NasdaqGM ˙ US8112922005

Basic Stats
LEI 529900XBHFGMNTU70154
CIK 1178253
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to SCYNEXIS, Inc.
SEC Filings (Chronological Order)
This page provides a complete, chronological list of SEC Filings, excluding ownership filings which we provide elsewhere.
August 13, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001-3636

July 1, 2025 8-K

FORM 8-K Item 5.07 Submission of Matters to a Vote of Security Holders.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2025 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

June 26, 2025 8-K

FORM 8-K Item 3.01 Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 20, 2025 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

May 15, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001-363

April 30, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒    Filed by a party other than the Registrant  ☐ Check the appropriate box:          ☐     Preliminary Proxy Statement  ☐     Confidential, for Use of the Commis

April 30, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒    Filed by a party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-

March 12, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS, Inc.

March 12, 2025 EX-19.1

Insider Trading Policy

Exhibit 19.1 SCYNEXIS, inc. INSIDER TRADING AND TRADING WINDOW POLICY (Revised December 31, 2018) I. Introduction This policy determines acceptable transactions in the securities of SCYNEXIS, Inc. (the “Company”) by our employees, directors and consultants. During the course of your employment, directorship or consultancy with the Company, you may receive important information that is not yet publ

February 14, 2025 EX-99

JOINT FILING AGREEMENT

EX-99 2 d11606582ex99-a.htm Exhibit A JOINT FILING AGREEMENT The undersigned agree that this Schedule 13G Amendment No. 6 dated February 14, 2025 relating to the Common Stock, par value $0.001 per share, of Scynexis, Inc. shall be filed on behalf of the undersigned. AVIDITY PARTNERS MANAGEMENT LP By Avidity Partners Management (GP) LLC, its general partner By: /s/ Michael Gregory Title: Managing M

January 8, 2025 EX-99

POWER OF ATTORNEY

EXHIBIT “3” POWER OF ATTORNEY Each person whose signature appears below constitutes and appoints J.

January 8, 2025 EX-99

AGREEMENT FOR JOINT FILING OF SCHEDULE 13G

EXHIBIT 2 AGREEMENT FOR JOINT FILING OF SCHEDULE 13G The following parties hereby agree to file jointly the statement on Schedule 13G to which this Agreement is attached and any amendments thereto which may be deemed necessary pursuant to Regulation 13D-G under the Securities Exchange Act of 1934: 1.

January 8, 2025 EX-99

ITEM 3 CLASSIFICATION OF REPORTING PERSONS Identity and Classification of Each Reporting Person

EXHIBIT 1 ITEM 3 CLASSIFICATION OF REPORTING PERSONS Identity and Classification of Each Reporting Person IDENTITY CLASSIFICATION UNDER ITEM 3 Federated Hermes Adviser Series (d) Investment company registered under Section 8 of the Investment Company Act of 1940 (15 U.

January 8, 2025 EX-99

POWER OF ATTORNEY

EXHIBIT “3” POWER OF ATTORNEY Each person whose signature appears below constitutes and appoints J.

November 14, 2024 SC 13G/A

SCYX / SCYNEXIS, Inc. / Avidity Partners Management LP Passive Investment

SC 13G/A 1 d1153047813g-a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* Scynexis, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 811292200 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate

November 6, 2024 EX-1.1

Controlled Equity OfferingSM Sales Agreement, dated November 6, 2024, between SCYNEXIS, Inc. and Cantor Fitzgerald & Co.

Exhibit 1.1 Execution Version SCYNEXIS, INC. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement November 6, 2024 Cantor Fitzgerald & Co. 110 East 59th Street New York, NY 10022 Ladies and Gentlemen: SCYNEXIS, Inc. (the “Company”), confirms its agreement (this “Agreement”) with Cantor Fitzgerald & Co. (“Cantor”), as follows: 1. Issuance and Sale of Shar

November 6, 2024 424B5

Up to $50,000,000 Common Stock

Filed Pursuant to Rule 424(b)(5) Registration No. 333-275520 PROSPECTUS SUPPLEMENT (To Prospectus Dated November 27, 2023) Up to $50,000,000 Common Stock We have entered into a Controlled Equity OfferingSM Sales Agreement, or Sales Agreement, with Cantor Fitzgerald & Co., or Cantor Fitzgerald, relating to the shares of our common stock, par value $0.001 per share, offered by this prospectus supple

November 6, 2024 SC 13G/A

SCYX / SCYNEXIS, Inc. / FEDERATED HERMES, INC. Passive Investment

SC 13G/A 1 scynexisamend13.htm OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ….11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 13*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 811292200 (CUSIP Number) October 31, 2024 (Date of Event Which

November 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001

November 6, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 06, 2024 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File N

October 7, 2024 SC 13G/A

SCYX / SCYNEXIS, Inc. / FEDERATED HERMES, INC. Passive Investment

SC 13G/A 1 scynexisamend12.htm OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ….11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 12*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 811292200 (CUSIP Number) September 30, 2024 (Date of Event Whi

September 10, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 10, 2024 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File

September 10, 2024 EX-99.1

A dynamic force in the fight against infectious disease September 2024

A dynamic force in the fight against infectious disease September 2024 Forward-Looking Statement Certain statements regarding SCYNEXIS, Inc.

August 8, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001-36365 SCYNEXIS, Inc. (

June 20, 2024 EX-99.2

Forms of Stock Option Grant Notice, Stock Option Agreement and Notice of Exercise under the SCYNEXIS, Inc. 2024 Equity Incentive Plan.

Exhibit 99.2 SCYNEXIS, Inc. Stock Option Grant Notice (2024 Equity Incentive Plan) SCYNEXIS, Inc. (the “Company”) has granted to you (the “Optionholder”) an option to purchase the number of shares of Common Stock set forth below (the “Option”) under the SCYNEXIS, Inc. 2024 Equity Incentive Plan (the “Plan”). The Option is subject to all of the terms and conditions set forth in this Stock Option Gr

June 20, 2024 EX-99.3

Forms of Restricted Stock Unit Grant Notice and Restricted Stock Unit Award Agreement under the SCYNEXIS, Inc. 2024 Equity Incentive Plan.

Exhibit 99.3 SCYNEXIS, Inc. RSU Award Grant Notice (2024 Equity Incentive Plan) SCYNEXIS, Inc. (the “Company”) has awarded to you (the “Participant”) the number of restricted stock units (the “RSUs”) specified and on the terms set forth below in consideration of your services (the “RSU Award”). The RSU Award is subject to all of the terms and conditions set forth in this RSU Award Grant Notice (th

June 20, 2024 EX-99.1

SCYNEXIS, Inc. 2024 Equity Incentive Plan.

Exhibit 99.1 SCYNEXIS, INC. 2024 EQUITY INCENTIVE PLAN ADOPTED BY THE BOARD OF DIRECTORS: April 12, 2024 APPROVED BY THE STOCKHOLDERS: June 19, 2024 TABLE OF CONTENTS Page 1. GENERAL. 1 2. SHARES SUBJECT TO THE PLAN. 1 3. ELIGIBILITY AND LIMITATIONS. 2 4. OPTIONS AND STOCK APPRECIATION RIGHTS. 3 5. AWARDS OTHER THAN OPTIONS AND STOCK APPRECIATION RIGHTS. 6 6. ADJUSTMENTS UPON CHANGES IN COMMON STO

June 20, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Table Form S-8 SCYNEXIS, Inc. Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Share (2) Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, par value $0.001 457(c) and 457(h) 6,150,000 $ 2.02 $ 12,423,000 0.0001476 $ 1,83

June 20, 2024 S-8

As filed with the Securities and Exchange Commission on June 20, 2024

As filed with the Securities and Exchange Commission on June 20, 2024 Registration No.

June 20, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 19, 2024 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

May 8, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001-36365 SCYNEXIS, Inc.

May 8, 2024 EX-10.1

Employment Agreement, dated November 15, 2017, between SCYNEXIS, Inc. and Scott Sukenick

Exhibit 10.1 EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT ("Agreement''), effective as of November 15, 2017 (the "Effective Date''), is by and between SCYNEXIS, Inc., a Delaware corporation ("Employer" or "Company' and Scott Sukenick ("Employee''). RECITALS: WHEREAS, Employer considers the availability of Employee's services to be important to the management and conduct of Employer's business an

May 8, 2024 EX-10.2

Non-Employee Director Compensation Policy, as amended.

Exhibit 10.2 SCYNEXIS Non-Employee Director Compensation Policy Revised April 2024 Our non-employee directors are compensated in accordance with the following policy: Each non-employee director receives an annual base cash retainer of $45,000 for such service, to be paid quarterly. In addition, the chairman of the Board receives an additional annual base cash retainer of $35,000, to be paid quarte

April 25, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒   Filed by a party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as per

April 25, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒   Filed by a party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-

March 28, 2024 EX-10.41

Binding Memorandum of Understanding for Amendment to Exclusive License Agreement and Transitional Manufacturing and Supply Agreement, dated as of December 26, 2023, by and between GlaxoSmithKline Intellectual Property (No. 3) Limited, and the Company.

Exhibit 10.41 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. BINDING MEMORANDUM OF UNDERSTANDING FOR AMENDMENT TO EXCLUSIVE LICENSE AGREEMENT AND TRANSITIONAL MANUFACTURING AND SUPPLY AGREEMENT This Binding Memorandum of Understanding for A

March 28, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 28, 2024 SCYNEXIS, Inc.

March 28, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS, Inc.

March 28, 2024 EX-10.21

Non-Employee Director Compensation Policy

Exhibit 10.21 SCYNEXIS Non-Employee Director Compensation Policy Revised December 2023; Effective January 1, 2024 Our non-employee directors are compensated in accordance with the following policy: Each non-employee director receives an annual base cash retainer of $45,000 for such service, to be paid quarterly. In addition, the chairman of the Board receives an additional annual base cash retaine

March 28, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-8 SCYNEXIS, Inc. Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Share (2) Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, par value $0.001 457(h) 1,916,962 $ 1.43 $ 2,741,256 0.0001476 $ 404.61 Equity Co

March 28, 2024 S-8

As filed with the Securities and Exchange Commission on March 28, 2024

As filed with the Securities and Exchange Commission on March 28, 2024 Registration No.

March 28, 2024 EX-97.1

Incentive Compensation Recoupment Policy

Exhibit 97.1 SCYNEXIS, INC. Incentive Compensation Recoupment Policy 1. Introduction The Compensation Committee (the “Compensation Committee”) of the Board of Directors (the “Board”) of SCYNEXIS, Inc., a Delaware corporation (the “Company”), and the Board have determined that it is in the best interests of the Company and its stockholders to adopt this Incentive Compensation Recoupment Policy (thi

March 28, 2024 EX-99.1

SCYNEXIS Reports Full Year 2023 Financial Results and Provides Corporate Update

Exhibit 99.1 SCYNEXIS Reports Full Year 2023 Financial Results and Provides Corporate Update • SCY-247’s IND-enabling activities continue to advance with initiation of Phase I anticipated in the second half of 2024 • Data analysis for the FURI study is ongoing; top line data from the CARES study has been received and is positive and consistent with previously disclosed results from interim analyse

February 13, 2024 SC 13G/A

SCYX / SCYNEXIS, Inc. / Avidity Partners Management LP Passive Investment

SC 13G/A 1 d1098044613g-a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* Scynexis, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 811292200 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate b

February 13, 2024 SC 13G/A

SCYX / SCYNEXIS, Inc. / Stonepine Capital Management, LLC Passive Investment

SC 13G/A 1 scyx13ga.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Scynexis, Inc. (Name of Issuer) Common Stock, par value $0.001per share (Title of Class of Securities) 811292200 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to

February 13, 2024 SC 13G/A

SCYX / SCYNEXIS, Inc. / CAXTON CORP Passive Investment

SC 13G/A 1 d1096535913g-a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* SCYNEXIS, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 811292200 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate b

January 18, 2024 SC 13G/A

SCYX / SCYNEXIS, Inc. / FEDERATED HERMES, INC. Passive Investment

SC 13G/A 1 scyx1577-form.htm OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ….11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 11*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 811292200 (CUSIP Number) December 31, 2023 (Date of Event Which

January 5, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 05, 2024 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File Nu

January 5, 2024 EX-99.1

A dynamic force in the fight against infectious disease January 2024

A dynamic force in the fight against infectious disease January 2024 Forward-Looking Statement Certain statements regarding SCYNEXIS, Inc.

January 2, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 26, 2023 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File N

November 29, 2023 SC 13G/A

SCYX / Scynexis Inc / KINGDON CAPITAL MANAGEMENT, L.L.C. Passive Investment

SC 13G/A 1 d1088830213g-a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* SCYNEXIS, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 811292200 (CUSIP Number) November 20, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate b

November 28, 2023 424B5

32,516,267 Shares Common Stock

424B5 Table of Contents As Filed Pursuant to Rule 424(b)(5) Registration No. 333-275513 PROSPECTUS 32,516,267 Shares Common Stock This prospectus relates to the offer and sale by us of 32,516,267 shares of our common stock, par value $0.001 per share, that are issuable upon the exercise of warrants, of which (i) warrants to purchase 6,800,000 shares of our common stock at an exercise price of $8.2

November 28, 2023 424B5

$200,000,000 Common Stock Preferred Stock Debt Securities

424B5 Table of Contents As Filed Pursuant to Rule 424(b)(5) Registration No. 333-275520 PROSPECTUS $200,000,000 Common Stock Preferred Stock Debt Securities Warrants From time to time, we may offer and sell up to an aggregate amount of $200,000,000 any combination of the securities described in this prospectus, either individually or in combination. We may also offer common stock or preferred stoc

November 21, 2023 CORRESP

SCYNEXIS, INC. 1 Evertrust Plaza, 13th Floor Jersey City, New Jersey 07302-6548

SCYNEXIS, INC. 1 Evertrust Plaza, 13th Floor Jersey City, New Jersey 07302-6548 November 21, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Cindy Polynice RE: SCYNEXIS, Inc. Registration Statement on Form S-3 Filed November 13, 2023 File No. 333-275520 Acceleration Request Requested Date: November 27,

November 21, 2023 CORRESP

SCYNEXIS, INC. 1 Evertrust Plaza, 13th Floor Jersey City, New Jersey 07302-6548

SCYNEXIS, INC. 1 Evertrust Plaza, 13th Floor Jersey City, New Jersey 07302-6548 November 21, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Cindy Polynice RE: SCYNEXIS, Inc. Registration Statement on Form S-3 Filed November 13, 2023 File No. 333-275513 Acceleration Request Requested Date: November 27,

November 13, 2023 S-3

As filed with the Securities and Exchange Commission on November 13, 2023

S-3 Table of Contents As filed with the Securities and Exchange Commission on November 13, 2023 Registration No.

November 13, 2023 EX-FILING FEES

Filing Fee Table

EX-FILING FEES Exhibit 107 Calculation of Filing Fee Table Form S-3 (Form Type) SCYNEXIS, Inc.

November 13, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001-36365 SCYNEXIS, I

November 13, 2023 EX-10.3

Third Amendment to Termination and License Agreement between the Company and Merck Sharp & Dohme Corp., dated January 5, 2018 (Filed with the SEC as Exhibit 10.3 to our Form 10-Q, filed with the SEC on November 13, 2023, SEC File No. 001-36365, and incorporated by reference here).

[*] = Certain information in this document has been excluded as such information is not material and is the type of information that the Company treats as private or confidential.

November 13, 2023 EX-10.2

Second Amendment to Termination and License Agreement between the Company and Merck Sharp & Dohme Corp. (Filed with the SEC as Exhibit 10.2 to our Form 10-Q, filed with the SEC on November 13, 2023, SEC File No. 001-36365, and incorporated by reference here).

[*] = Certain information in this document has been excluded as such information is not material and is the type of information that the Company treats as private or confidential.

November 13, 2023 EX-10.1

Amendment to Termination and License Agreement, dated December 3, 2014, between SCYNEXIS, Inc. and Merck Sharp & Dohme Corp. (Filed with the SEC as Exhibit 10.1 to our Form 10-Q, filed with the SEC on November 13, 2023, SEC File No. 001-36365, and incorporated by reference here).

[*] = Certain information in this document has been excluded as such information is not material and is the type of information that the Company treats as private or confidential.

November 13, 2023 EX-4.7

Form of Common Stock Warrant Agreement and Warrant Certificate

EX-4.7 Exhibit 4.7 SCYNEXIS, INC. AND , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT DATED AS OF SCYNEXIS, INC. FORM OF COMMON STOCK WARRANT AGREEMENT THIS COMMON STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [•], between, SCYNEXIS, INC., a Delaware corporation (the “Company”) and [•], a [corporation] [national banking association] organized and existing under the laws of [•]

November 13, 2023 S-3

As filed with the Securities and Exchange Commission on November 13, 2023

S-3 Table of Contents As filed with the Securities and Exchange Commission on November 13, 2023 Registration No.

November 13, 2023 EX-FILING FEES

Filing Fee Table

EX-FILING FEES Exhibit 107 Calculation of Filing Fee Table Form S-3 (Form Type) SCYNEXIS, Inc.

November 13, 2023 EX-4.8

Form of Preferred Stock Warrant Agreement and Warrant Certificate

EX-4.8 Exhibit 4.8 SCYNEXIS, INC. AND , AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OF SCYNEXIS, INC. FORM OF PREFERRED STOCK WARRANT AGREEMENT THIS PREFERRED STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [•], between SCYNEXIS, INC., a Delaware corporation (the “Company”) and [•], a [corporation] [national banking association] organized and existing under the laws

October 2, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 27, 2023 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File

September 25, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 19, 2023 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File

August 14, 2023 EX-10.1

Payoff Letter with Hercules Capital, Inc. dated May 25, 2023 (Filed with the SEC as Exhibit 10.1 to our Form 10-Q with the SEC on August 14, 2023, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN REDACTED PURSUANT TO ITEM 601(A)(6) OF REGULATION S-K. May 25, 2023 Scynexis, Inc. 1 Evertrust Plaza, 13th Floor Jersey City, New Jersey 07302 Attn: Legal Department With a copy to: Cooley LLP 101 California Street, 5th Floor San Francisco, California 94114 Attn: Maricel Mojares-Moore Re: Payoff of

August 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001-36365 SCYNEXIS, Inc. (

July 18, 2023 EX-99.1

SCYNEXIS, Inc. 2014 Employee Stock Purchase Plan, as amended and restated. (Filed with the SEC as Exhibit 99.1 to our Form S-8, filed with the SEC on July 18, 2023, SEC File No. 333-273305, and incorporated by reference here).

Exhibit 99.1 SCYNEXIS, Inc. 2014 Employee Stock Purchase Plan Adopted by the Board of Directors: February 11, 2014 Approved by the Stockholders: February 25, 2014 Adjusted for Reverse Stock Split: July 17, 2020 Amended by the Board of Directors: April 14, 2023 Approved by the Stockholders: June 14, 2023 1. General; Purpose. (a) The Plan provides a means by which Eligible Employees of the Company a

July 18, 2023 S-8

SCYNEXIS, Inc. 2014 Employee Stock Purchase Plan (Filed with the SEC as Exhibit 99.1 to our Form S-8, filed with the SEC on July 18, 2023, SEC File No. 333-273305, and incorporated by reference here).

As filed with the Securities and Exchange Commission on July 18, 2023 Registration No.

July 18, 2023 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Table Form S-8 SCYNEXIS, Inc. Table 1: Newly Registered Securities Calculation of Filing Fee Table Form S-8 SCYNEXIS, Inc. Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Share (2) Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Co

June 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 25, 2023 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File Number

June 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 14, 2023 SCYNEXIS, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-36365 56-2181648 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

June 9, 2023 SC 13G

SCYX / Scynexis Inc / Stonepine Capital Management, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Scynexis, Inc. (Name of Issuer) Common Stock, par value $0.001per share (Title of Class of Securities) 811292200 (CUSIP Number) May 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant t

May 10, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001-36365 SCYNEXIS, Inc.

May 10, 2023 EX-10

Separation Agreement, dated October 20, 2022, between SCYNEXIS, Inc. and Christine Coyne.

Exhibit 10.3 October 20, 2022 Christine Rose Coyne Dear Christine: This letter sets forth the substance of the separation agreement (the “Agreement”) that SCYNEXIS, Inc. (the “Company”) is offering to you to aid in your employment transition. 1. Separation. Your last day of work with the Company and your employment termination date will be November 30, 2022 (the “Separation Date”). 2. Accrued Sala

May 10, 2023 EX-10

First Amendment and Consent to Loan and Security Agreement, dated March 30, 2023, among the Company, Hercules Capital, Inc., and Silicon Valley Bank (Filed with the SEC as Exhibit 10.2. to our Form 10-Q, filed with the SEC on May 10, 2023, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.2 First AMENDMENT AND CONSENT TO LOAN AND SECURITY AGREEMENT This First Amendment AND CONSENT to Loan and Security Agreement (this “Amendment”) is dated as of March 30, 2023 and is entered into by and among SCYNEXIS, INC., a Delaware corporation (“Borrower”), HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative agent and collateral agent (“Agent”), SILICON V

May 10, 2023 EX-10

Exclusive License Agreement, dated as of March 30, 2023, by and between GlaxoSmithKline Intellectual Property (No.3) Limited, and the Company (Filed with the SEC as Exhibit 10.1 to our Form 10-Q, filed with the SEC on May 10, 2023, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. EXCLUSIVE LICENSE AGREEMENT BY AND BETWEEN SCYNEXIS, INC. AND GlaxoSmithKline Intellectual Property (No. 3) Limited DATED AS OF March 30, 2023 Table of Contents Page Article 1 DEFI

May 1, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒   Filed by a party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-

May 1, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒   Filed by a party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as pe

April 19, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒   Filed by a party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as per

April 13, 2023 SC 13G

SCYX / Scynexis Inc / KINGDON CAPITAL MANAGEMENT, L.L.C. Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

April 3, 2023 SC 13G/A

SCYX / Scynexis Inc / HIRSCHMAN ORIN Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Amendment No. 4 Under the Securities Exchange Act of 1934 SCYNEXIS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 811292101 (CUSIP Number) March 22, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is

March 31, 2023 EX-10

Separation Agreement, dated October 20, 2022, between SCYNEXIS, Inc. and Marco Taglietti.

Exhibit 10.38 October 20th, 2022 Dr. Marco Taglietti Dear Marco: This letter sets forth the substance of the separation agreement (the “Agreement”) that SCYNEXIS, Inc. (the “Company”) is offering to you. 1. Separation. Your last day of work with the Company and your employment termination date will be December 31, 2022 (the “Separation Date”). 2. Accrued Salary and Paid Time Off. By the date requi

March 31, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-8 SCYNEXIS, Inc. Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Share (2) Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, par value $0.001 457(h) 1,901,960 $ 1.84 $ 3,499,606 0.0001102 $ 385.66 Equity Co

March 31, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS, Inc.

March 31, 2023 S-8

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 SCYNEXIS, Inc. (Exact name of Registrant as specified in its charter)

As filed with the Securities and Exchange Commission on March 31, 2023 Registration No.

March 31, 2023 EX-10

Employment Agreement, dated January 1, 2023, between SCYNEXIS, Inc. and David Angulo (Filed with the SEC as Exhibit 10.39 to our Form 10-K, filed with the SEC on March 31, 2023, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.39 EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (“Agreement”), effective as of January 1, 2023 (the “Effective Date”), is by and between SCYNEXIS, Inc., a Delaware corporation (“Employer” or “Company”) and David Angulo Gonzalez, MD (“Employee”). RECITALS: WHEREAS, Employer considers the availability of Employee's services to be important to the management and conduct of Employer's bus

March 31, 2023 EX-10

Employment Agreement, dated October 24, 2022, between SCYNEXIS, Inc. and Ivor Macleod (Filed with the SEC as Exhibit 10.40 to our Form 10-K, filed with the SEC on March 31, 2023, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.40 EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT ("Agreement"), effective as of October 24, 2022 (the "Effective Date"), is by and between SCYNEXIS, Inc., a Delaware corporation ("Employer" or "Company") and Ivor Macleod ("Employee"). RECITALS: WHEREAS, Employer considers the availability of Employee's services to be important to the management and conduct of Employer's business and de

March 30, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 30, 2023 SCYNEXIS, Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 30, 2023 SCYNEXIS, Inc.

February 15, 2023 SC 13G/A

SCYX / SCYNEXIS Inc / HIRSCHMAN ORIN Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Amendment No. 3 Under the Securities Exchange Act of 1934 SCYNEXIS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 811292101 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 14, 2023 SC 13G/A

SCYX / SCYNEXIS Inc / Avidity Partners Management LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 14, 2023 SC 13G/A

SCYX / SCYNEXIS Inc / ARMISTICE CAPITAL, LLC Passive Investment

SC 13G/A 1 armistice-scyx123122a1.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* SCYNEXIS, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 811292200 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the app

February 1, 2023 SC 13G/A

SCYX / SCYNEXIS Inc / FEDERATED HERMES, INC. Passive Investment

OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ….11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 10*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 811292200 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this State

November 10, 2022 S-8

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 SCYNEXIS, Inc. (Exact name of Registrant as specified in its charter)

S-8 1 forms-8-11112022.htm S-8 As filed with the Securities and Exchange Commission on November 10, 2022 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SCYNEXIS, Inc. (Exact name of Registrant as specified in its charter) Delaware 56-2181648 (State or other jurisdiction of incorporation

November 10, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-8 SCYNEXIS, Inc. Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Share (2) Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, par value $0.001 457(h) 400,000 $ 2.235 $ 894,000 0.0001102 $ 98.52 Total Offerin

November 9, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 9, 2022 SCYNEXIS, Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 9, 2022 SCYNEXIS, Inc.

November 9, 2022 EX-99.1

SCYNEXIS Reports Third Quarter 2022 Financial Results and Provides Corporate Update

SCYNEXIS Reports Third Quarter 2022 Financial Results and Provides Corporate Update • SCYNEXIS recently announced new strategic direction to refocus its resources on the clinical development of ibrexafungerp for severe, hospital-based indications.

November 9, 2022 EX-10.2

Form of Restricted Stock Award Grant Notice and Restricted Stock Award Agreement under the Amended and Restated 2015 Inducement Award Plan.(Filed with the SEC as Exhibit 10.2 to our Form 10-Q, filed with the SEC on November 9, 2022, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.2 Scynexis, Inc. Restricted Stock Unit Award Grant Notice 2015 Inducement Award Plan SCYNEXIS, Inc. (the ?Company?) hereby awards to Participant the number of Restricted Stock Units specified and on the terms set forth below (the ?Award?). The Award is subject to all of the terms and conditions as set forth in this Restricted Stock Unit Grant Notice (the ?Grant Notice?), in the Restrict

November 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended SEPTEMBER 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001-36365 SCYNEXIS, I

November 9, 2022 EX-3.4

Certificate of Amendment of Amended and Restated Certificate of Incorporation of SCYNEXIS, Inc. (Filed with the SEC as Exhibit 3.4 to our Form 10-Q, filed with SEC on November 9, 2022, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 3.4 CERTIFICATE OF AMENDMENT OF AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF SCYNEXIS, Inc. SCYNEXIS, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the ?Corporation?), hereby certifies that: First: The name of the Corporation is SCYNEXIS, Inc. The Corporation was originally incorporated under the name Scyrex,

November 9, 2022 EX-10.1

SCYNEXIS, Inc. Amended and Restated 2015 Inducement Award Plan, as amended and restated. (Filed with the SEC as Exhibit 10.1 to our Quarterly Report on Form 10-Q, filed with the SEC on November 9, 2022, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.1 SCYNEXIS, INC. 2015 INDUCEMENT AWARD PLAN ADOPTED: March 26, 2015 Amended: June 9, 2019 ADJUSTED FOR REVERSE STOCK SPLIT: July 17, 2020 FURTHER AMENDED: April 30, 2021 FURTHER AMENDED: OCTOBER 18, 2022 1. GENERAL. (a) Eligible Award Recipients. The persons eligible to receive Stock Awards are Eligible Employees as of the date of grant. (b) Available Awards. The Plan provides for the g

October 20, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 14, 2022 SCYNEXIS, Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 14, 2022 SCYNEXIS, Inc.

September 30, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 28, 2022 SCYNEXIS, Inc.

August 19, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ?) Filed by the Registrant ? ? ? Filed by a party other than the Registrant ?? Check the appropriate box: ?? Preliminary Proxy Statement ?? Confidential, for Use of the Commission Only (as

August 15, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 15, 2022 SCYNEXIS, Inc.

August 15, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended JUNE 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001-36365 SCYNEXIS, Inc. (

August 15, 2022 EX-10.1

Non-Employee Director Compensation Policy.

Exhibit 10.1 SCYNEXIS Non-Employee Director Compensation Policy Revised June 2022 Our non-employee directors are compensated in accordance with the following policy: Each non-employee director receives an annual base cash retainer of $40,000 for such service, to be paid quarterly. In addition, the chairman of the Board receives an additional annual base cash retainer of $35,000, to be paid quarter

August 15, 2022 EX-99.1

SCYNEXIS Reports Second Quarter 2022 Financial Results and Provides Corporate Update

SCYNEXIS Reports Second Quarter 2022 Financial Results and Provides Corporate Update ? BREXAFEMME? (ibrexafungerp tablets) prescriptions in Q2 2022 increased 29 percent over Q1 2022, generating net revenues of $1.

August 8, 2022 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ?) Filed by the Registrant ? ? ? Filed by a party other than the Registrant ?? Check the appropriate box: ? Preliminary Proxy Statement ?? Confidential, for Use of the Commission Only (as p

June 17, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): June 16, 2022 SCYNEXIS, Inc.

May 12, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 12, 2022 SCYNEXIS, Inc.

May 12, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended MARCH 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period to Commission File Number 001-36365 SCYNEXIS, Inc.

May 12, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ?) Filed by the Registrant ????Filed by a party other than the Registrant ?? Check the appropriate box: ?? ? ? Preliminary Proxy Statement ?? ? ? Confidential, for Use of the Commission Onl

May 12, 2022 EX-99.1

SCYNEXIS Reports First Quarter 2022 Financial Results and Provides Corporate Update

Exhibit 99.1 SCYNEXIS Reports First Quarter 2022 Financial Results and Provides Corporate Update ? BREXAFEMME? (ibrexafungerp tablets), launched in September 2021 for the treatment of vulvovaginal candidiasis (VVC), achieved almost 4,000 prescriptions with net revenues of $0.7 million in Q1 2022. Expansion of the labeling to include prevention of recurrent VVC is anticipated by end of 2022. ? As o

May 12, 2022 EX-10.1

Employment Agreement, dated May 10, 2021, between SCYNEXIS, Inc. and Christine Coyne (Filed with the SEC as Exhibit 10.1 to our Annual Report on Form 10-Q, filed with the SEC on May 12, 2022, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.1 EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT ("Agreement"), effective as of May 10, 2021 (the "Effective Date"), is by and between SCYNEXIS, Inc., a Delaware corporation ("Employer" or "Company") and Christine Coyne ("Employee"). RECITALS: WHEREAS, Employer considers the availability of Employee's services to be important to the management and conduct of Employer's business and desi

May 2, 2022 EX-10.36

Non-Employee Director Compensation Policy

Exhibit 10.36 SCYNEXIS Non-Employee Director Compensation Policy Revised January 2022 Our non-employee directors are compensated in accordance with the following policy: Each non-employee director receives an annual base cash retainer of $40,000 for such service, to be paid quarterly. In addition, the chairman of the Board receives an additional annual base cash retainer of $35,000, to be paid qua

May 2, 2022 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ?) Filed by the Registrant ????Filed by a party other than the Registrant ?? Check the appropriate box: ? ? ? Preliminary Proxy Statement ?? ? ? Confidential, for Use of the Commission Only

May 2, 2022 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-3

April 22, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 22, 2022 SCYNEXIS, Inc.

April 22, 2022 EX-4.1

Form of Warrant

Exhibit 4.1 COMMON STOCK PURCHASE WARRANT SCYNEXIS, INC. Warrant Shares: Issue Date: , 2022 Initial Exercise Date: , 2022 THIS COMMON STOCK PURCHASE WARRANT (the ?Warrant?) of SCYNEXIS, Inc., a Delaware corporation (the ?Company?), certifies that, for value received, or its assigns (the ?Holder?) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter

April 22, 2022 EX-1.1

Equity Underwriting Agreement, dated April 22, 2022, by and between the Company and Guggenheim Securities, LLC, as representative of the several underwriters named on Schedule I thereto

EX-1.1 2 scyx-ex119.htm EX-1.1 Exhibit 1.1 3,333,333 Shares of Common Stock ($0.001 Par Value) Pre-Funded Warrants to Purchase Up to 11,666,667 Shares of Common Stock Warrants to Purchase Up to 15,000,000 Shares of Common Stock SCYNEXIS, Inc. Common Stock EQUITY UNDERWRITING AGREEMENT April 22, 2022 Guggenheim Securities, LLC As Representative of the several Underwriters named in Schedule I attach

April 22, 2022 EX-4.2

Form of Pre-Funded Warrant

Exhibit 4.2 PURSUANT TO THE TERMS OF SECTION 1 OF THIS WARRANT, ALL OR A PORTION OF THIS WARRANT MAY HAVE BEEN EXERCISED OR CANCELED, AND THEREFORE THE ACTUAL NUMBER OF WARRANT SHARES REPRESENTED BY THIS WARRANT MAY BE LESS THAN THE AMOUNTS SET FORTH ON THE FACE HEREOF. ANY TRANSFEREE OF THIS WARRANT SHOULD CONTACT SCYNEXIS, INC. IN ADVANCE OF ACQUIRING THIS WARRANT TO BE APPRISED OF THE ACTUAL NU

April 22, 2022 FWP

SCYNEXIS Announces Positive Interim Data from Phase 3 FURI and CARES Studies Highlighting Oral Ibrexafungerp’s Potency Against Severe Fungal Infections

Issuer Free Writing Prospectus Filed Pursuant to Rule 433 Registration No. 333-251851 April 22, 2022 SCYNEXIS Announces Positive Interim Data from Phase 3 FURI and CARES Studies Highlighting Oral Ibrexafungerp?s Potency Against Severe Fungal Infections ? Data reinforce findings from previous analyses demonstrating oral ibrexafungerp?s potential to combat difficult-to-treat and refractory fungal in

April 22, 2022 424B5

3,333,333 Shares Common Stock Pre-Funded Warrants to Purchase 11,666,667 Shares of Common Stock Common Warrants to Purchase up to 15,000,000 Shares of Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-251851 PROSPECTUS SUPPLEMENT (To Prospectus dated January 8, 2021) 3,333,333 Shares Common Stock Pre-Funded Warrants to Purchase 11,666,667 Shares of Common Stock Common Warrants to Purchase up to 15,000,000 Shares of Common Stock We are offering shares of our common stock. Each investor will also receive a warrant to purchase one share of o

April 21, 2022 424B5

Common Stock Pre-Funded Warrants to Purchase Shares of Common Stock Common Warrants to Purchase up to Shares of Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-251851 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been declared effective by the Securities and Exchange Commission. This preliminary prospectus supplement is not an offer to sell nor does it seek an offer to buy these securities in a

March 30, 2022 EX-FILING FEES

Filing Fee Table

EX-FILING FEES 2 scyx-exfilingfees6.htm EX-FILING FEES Calculation of Filing Fee Table Form S-8 SCYNEXIS, Inc. Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Share (2) Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, par value $0.001 457(h) 1,148,213 $ 4.

March 30, 2022 S-8

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 SCYNEXIS, Inc. (Exact name of Registrant as specified in its charter)

As filed with the Securities and Exchange Commission on March 29, 2022 Registration No.

March 29, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 29, 2022 SCYNEXIS, Inc.

March 29, 2022 EX-99.1

SCYNEXIS Reports Fourth Quarter and Full Year 2021 Financial Results and Provides Corporate Update

SCYNEXIS Reports Fourth Quarter and Full Year 2021 Financial Results and Provides Corporate Update ? BREXAFEMME? (ibrexafungerp tablets), launched in August 2021, achieved net revenues of $1.

March 29, 2022 EX-4.2

Exhibit 4.2

Exhibit 4.2 SCYNEXIS, INC. DESCRIPTION OF COMMON STOCK SCYNEXIS, Inc. (?we,? ?our,? ?us,? or the ?Company,?) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the ?Exchange Act?): our common stock. The following description of our common stock does not purport to be complete and is subject in all respects to applicable Delaware law and to t

March 29, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS, Inc.

March 10, 2022 8-K

Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 9, 2022 SCYNEXIS, Inc.

February 14, 2022 SC 13G/A

SCYX / SCYNEXIS Inc / FEDERATED HERMES, INC. Passive Investment

OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ?.11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 9*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 811292101 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statem

February 14, 2022 SC 13G/A

SCYX / SCYNEXIS Inc / PERCEPTIVE ADVISORS LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* SCYNEXIS, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 811292 200 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule

February 14, 2022 EX-99.1

AGREEMENT

EX-99.1 EXHIBIT 1 AGREEMENT The persons below hereby agree that the Schedule 13G to which this agreement is attached as an exhibit, as well as all future amendments to such Schedule 13G, shall be filed on behalf of each of them. This agreement is intended to satisfy the requirements of Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934. Date: February 14, 2022 PERCEPTIVE ADVISORS LLC

February 14, 2022 SC 13G/A

SCYX / SCYNEXIS Inc / Stonepine Capital Management, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* SCYNEXIS, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 811292200 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pur

February 14, 2022 SC 13G/A

SCYX / SCYNEXIS Inc / Avidity Partners Management LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 14, 2022 SC 13G/A

SCYX / SCYNEXIS Inc / CAXTON CORP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 11, 2022 SC 13G/A

SCYX / SCYNEXIS Inc / HIRSCHMAN ORIN Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Amendment No. 2 Under the Securities Exchange Act of 1934 SCYNEXIS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 811292101 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 8, 2022 EX-10.1

Form of Restricted Stock Unit Grant Notice and Award Agreement under the 2014 Equity Incentive Plan (Filed with the SEC as Exhibit 10.1 to our Form 8-K, filed with the SEC on February 8, 2022, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.1 2014 SCYNEXIS, Inc. Restricted Stock Unit Award Grant Notice 2014 Equity Incentive plan SCYNEXIS, Inc. (the ?Company?) hereby awards to Participant the number of Restricted Stock Units specified and on the terms set forth below (the ?Award?). The Award is subject to all of the terms and conditions as set forth in this Restricted Stock Unit Grant Notice (the ?Grant Notice?), in the Res

February 8, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 4, 2022 SCYNEXIS, Inc.

December 10, 2021 SC 13G/A

SCYX / SCYNEXIS Inc / FEDERATED HERMES, INC. Passive Investment

OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ?.11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 8*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 811292101 (CUSIP Number) November 30, 2021 (Date of Event Which Requires Filing of this Statem

November 12, 2021 SC 13G/A

SCYX / SCYNEXIS Inc / HIRSCHMAN ORIN Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Amendment No. 1 Under the Securities Exchange Act of 1934 SCYNEXIS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 811292101 (CUSIP Number) November 9, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule i

November 10, 2021 EX-99.1

SCYNEXIS Reports Third Quarter 2021 Financial Results and Provides Corporate Update

SCYNEXIS Reports Third Quarter 2021 Financial Results and Provides Corporate Update ? BREXAFEMME? (ibrexafungerp tablets) net sales of $0.

November 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 10, 2021 SCYNEXIS, Inc.

November 10, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEX

November 4, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 1, 2021 SCYNEXIS, Inc.

October 29, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 26, 2021 SCYNEXIS, Inc.

September 17, 2021 424B3

5,271,015 Shares Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-259300 5,271,015 Shares Common Stock This prospectus relates to the offer and sale by us of 5,271,015 shares of our common stock, par value $0.001 per share, that are issuable upon the exercise of warrants, of which (i) warrants to purchase 798,810 shares of our common stock at an exercise price of $20.00 per share were originally issued by us

September 17, 2021 424B3

$16,798,087 of Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-259300 $16,798,087 of Common Stock Pursuant to this prospectus we are offering up to $16,798,087 aggregate amount of our common stock, par value $0.001 per share (the ?Purchase Shares?), to Aspire Capital Fund, LLC (?Aspire Capital?) under a Common Stock Purchase Agreement entered into on April 10, 2020 (?Purchase Agreement?). The Purchase Shar

September 13, 2021 CORRESP

SCYNEXIS, Inc. 1 Evertrust Plaza, 13th Floor Jersey City, NJ 07302-6548

SCYNEXIS, Inc. 1 Evertrust Plaza, 13th Floor Jersey City, NJ 07302-6548 Via Edgar September 10, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attn: Laura Crotty Re: SCYNEXIS, Inc. Registration Statement on Form S-3 Filed September 3, 2021 File No. 333- 259300 Ladies and Gentlemen: The undersigned registrant hereby requests that

September 3, 2021 S-3

As filed with the Securities and Exchange Commission on September 3, 2021

As filed with the Securities and Exchange Commission on September 3, 2021 Registration No.

August 16, 2021 EX-10.1

Loan and Security Agreement, dated May 13, 2021, among the Company, Hercules Capital Inc., and Silicon Valley Bank (Filed with the SEC as Exhibit 10.1 to our Form 10-Q, filed with the SEC on August 16, 2021, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.1 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (this ?Agreement?) dated as of May 13, 2021 (the ?Effective Date?), among (a) HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative agent and collateral agent (?Agent?), (b) SILICON VALLEY BANK, a California corporation, as a lender (?SVB?), (c) HERCULES CAPITAL, INC., a Maryland corporation (?Her

August 16, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS, I

August 16, 2021 EX-10.2

Non-employee Director Compensation Policy (Filed with the SEC as Exhibit 10.2 to our Form 10-Q, filed with the SEC on August 16, 2021, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.2 SCYNEXIS Non-Employee Director Compensation Policy Revised June 2021 Our non-employee directors are compensated in accordance with the following policy: Each non-employee director receives an annual base cash retainer of $40,000 for such service, to be paid quarterly. In addition, the chairman of the Board receives an additional annual base cash retainer of $30,000, to be paid quarter

June 24, 2021 8-K

Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): June 23, 2021 SCYNEXIS, Inc.

June 16, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): June 15, 2021 SCYNEXIS, Inc.

June 10, 2021 SC 13G

SCYX / SCYNEXIS Inc / HIRSCHMAN ORIN - SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 SCYNEXIS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 811292101 (CUSIP Number) June 2, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed o Rule 13d-1(b

May 18, 2021 EX-1.2

Controlled Equity OfferingSM Sales Agreement, dated May 17, 2021, between SCYNEXIS, Inc. and Ladenburg Thalmann & Co. Inc. (Filed with the SEC as Exhibit 1.2 to our Current Report on Form 8-K, filed with the SEC on May 18, 2021, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 1.2 SCYNEXIS, INC. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement May 17, 2021 Ladenburg Thalmann & Co. Inc. 277 Park Avenue, 26th Floor New York, New York 10172 Ladies and Gentlemen: SCYNEXIS, Inc. (the ?Company?), confirms its agreement (this ?Agreement?) with Ladenburg Thalmann & Co. Inc. (?Ladenburg?), as follows: 1.Issuance and Sale of

May 18, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 17, 2021 SCYNEXIS, Inc.

May 18, 2021 EX-1.1

Controlled Equity OfferingSM Sales Agreement, dated May 17, 2021, between SCYNEXIS, Inc. and Cantor Fitzgerald & Co. (Filed with the SEC as Exhibit 1.1 to our Current Report on Form 8-K, filed with the SEC on May 18, 2021, SEC File No. 001-36365, and incorporated by reference here).

EX-1.1 2 scyx-ex116.htm EX-1.1 Exhibit 1.1 SCYNEXIS, INC. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement May 17, 2021 Cantor Fitzgerald & Co. 499 Park Avenue New York, NY 10022 Ladies and Gentlemen: SCYNEXIS, Inc. (the “Company”), confirms its agreement (this “Agreement”) with Cantor Fitzgerald & Co. (“Cantor”), as follows: 1.Issuance and Sale of S

May 17, 2021 EX-10.1

Exclusive License and Collaboration Agreement, made as of February 11, 2021, by and between SCYNEXIS, Inc., Hansoh (Shanghai) Health Technology Co., Ltd. and Jiangsu Hansoh Pharmaceutical Group Company Limited (Filed with the SEC as Exhibit 10.1 to our Form 10-Q, filed with the SEC on May 17, 2021, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.1 [*] = Certain confidential information contained in this document, marked by brackets, is omitted because it is both (i) not material and (ii) is the type of information that SCYNEXIS, Inc. treats as private or confidential. EXCLUSIVE LICENSE AND COLLABORATION AGREEMENT This Exclusive License and Collaboration Agreement (this ?Agreement?) is made as of February 11, 2021 (the ?Effectiv

May 17, 2021 424B5

$50,000,000 Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-251851 PROSPECTUS SUPPLEMENT (To Prospectus dated January 8, 2021) $50,000,000 Common Stock We have entered into a Controlled Equity OfferingSM Sales Agreement, or Cantor sales agreement, with Cantor Fitzgerald & Co., or Cantor Fitzgerald, and a Controlled Equity OfferingSM Sales Agreement, or Ladenburg sales agreement, with Ladenburg Thalma

May 17, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS,

May 17, 2021 EX-10.2

Master Services Agreement, effective as of February 4, 2021, by and between SCYNEXIS, Inc. and Amplity, Inc. (Filed with the SEC as Exhibit 10.2 to our Form 10-Q, filed with the SEC on May 17, 2021, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.2 [*] = Certain confidential information contained in this document, marked by brackets, is omitted because it is both (i) not material and (ii) is the type of information that SCYNEXIS, Inc. treats as private or confidential. MASTER SERVICES AGREEMENT THIS MASTER SERVICES AGREEMENT (the ?Agreement?), effective as of February 4, 2021 (the ?Effective Date?), is by and between SCYNEXIS, I

May 14, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 13, 2021 SCYNEXIS, Inc.

May 10, 2021 EX-99.1

2015 Inducement Award Plan, as amended and restated (Filed with the SEC as Exhibit 99.1 to our Registration Statement on Form S-8, filed with the SEC on May 10, 2021, SEC File No. 333-255967, and incorporated by reference here)

Exhibit 99.1 SCYNEXIS, INC. 2015 INDUCEMENT AWARD PLAN ADOPTED: March 26, 2015 Amended: June 9, 2019 ADJUSTED FOR REVERSE STOCK SPLIT: July 17, 2020 FURTHER AMENDED: April 30, 2021 1. GENERAL. (a) Eligible Award Recipients. The persons eligible to receive Stock Awards are Eligible Employees as of the date of grant. (b) Available Awards. The Plan provides for the grant of the following Stock Awards

May 10, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on May 10, 2021 Registration No.

April 26, 2021 DEF 14A

Schedule 14A

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.?) Filed by the Registrant ? Filed by a Party other than the Registrant ?? Check the appropriate box: ?? ? ? Preliminary Proxy Statement ?? ? ? Confidential, for Use of the Commission Only (

April 26, 2021 DEFA14A

- FORM DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

March 29, 2021 EX-4.2

Exhibit 4.2

Exhibit 4.2 SCYNEXIS, INC. DESCRIPTION OF COMMON STOCK SCYNEXIS, Inc. (?we,? ?our,? ?us,? or the ?Company,?) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the ?Exchange Act?): our common stock. The following description of our common stock does not purport to be complete and is subject in all respects to applicable Delaware law and to t

March 29, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on March 29, 2021 Registration No.

March 29, 2021 EX-10.30

Fourth Amendment to Termination and License Agreement between SCYNEXIS, Inc. and Merck Sharp & Dohme Corp. dated December 2, 2020.

Exhibit 10.30 FOURTH AMENDMENT TO TERMINATION AND LICENSE AGREEMENT THIS FOURTH AMENDMENT TO TERMINATION AND LICENSE AGREEMENT (the ?Fourth Amendment?) is made and entered into as of December 2, 2020 by and between Merck Sharp & Dohme Corp., a New Jersey corporation with a place of business at One Merck Drive, Whitehouse Station, NJ 08889 (?Merck?) and SCYNEXIS, Inc., a Delaware corporation with a

March 29, 2021 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED December 31, 2020 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS, Inc.

March 10, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) (CUSIP Number) February 28,

OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ….11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 811292101 (CUSIP Number) February 28, 2021 (Date of Event Which Requires Filing of this Statem

February 23, 2021 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 19, 2021 SCYNEXIS, Inc.

February 17, 2021 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 11, 2021 SCYNEXIS, Inc.

February 16, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)*

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 16, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)*

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 12, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* SCYNEXIS, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* SCYNEXIS, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 811292200 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pur

February 12, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) (CUSIP Number) December 31,

OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ?.11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 811292101 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statem

February 11, 2021 SC 13G/A

SIGNATURE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.2) * Scynexis, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 811292200 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

January 27, 2021 EX-99.1

AGREEMENT

EX-99.1 2 d34407dex991.htm EX-99.1 EXHIBIT 1 AGREEMENT The persons below hereby agree that the Schedule 13G to which this agreement is attached as an exhibit, as well as all future amendments to such Schedule 13G, shall be filed on behalf of each of them. This agreement is intended to satisfy the requirements of Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934. Date: January 27, 202

January 27, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* SCYNEXIS, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) (

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* SCYNEXIS, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 811292 200 (CUSIP Number) December 21, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the r

January 6, 2021 CORRESP

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SCYNEXIS, Inc. 1 Evertrust Plaza, 13th Floor Jersey City, New Jersey 07302-6548 January 6, 2021 Via Email and Edgar U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Mail Stop 3720 Washington, D.C. 20549 Attn: Jeffrey Gabor RE: SCYNEXIS, Inc. Registration Statement on Form S-3 File No. 333-251851 Ladies and Gentlemen: SCYNEXIS, Inc. (the “Registrant”) hereb

December 31, 2020 S-3

- S-3

As filed with the Securities and Exchange Commission on December 31, 2020 Registration No.

December 23, 2020 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. ___)* SCYNEXIS, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* SCYNEXIS, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 811292200 (CUSIP Number) December 17, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule purs

December 23, 2020 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.)*

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

December 18, 2020 EX-4.1

Form of Pre-Funded Warrant

EX-4.1 3 scyx-ex4146.htm EX-4.1 Exhibit 4.1 PURSUANT TO THE TERMS OF SECTION 1 OF THIS WARRANT, ALL OR A PORTION OF THIS WARRANT MAY HAVE BEEN EXERCISED OR CANCELED, AND THEREFORE THE ACTUAL NUMBER OF WARRANT SHARES REPRESENTED BY THIS WARRANT MAY BE LESS THAN THE AMOUNTS SET FORTH ON THE FACE HEREOF. ANY TRANSFEREE OF THIS WARRANT SHOULD CONTACT SCYNEXIS, INC. IN ADVANCE OF ACQUIRING THIS WARRANT

December 18, 2020 EX-1.1

Equity Underwriting Agreement, dated December 17, 2020, by and between the Company and Guggenheim Securities, LLC, as representative of the several underwriters named on Schedule I thereto

EX-1.1 2 scyx-ex1133.htm EX-1.1 Execution Version 8,340,000 Shares of Common Stock ($0.001 Par Value) Pre-Funded Warrants to Purchase Up to 5,260,000 Shares of Common Stock Series 1 Warrants to Purchase Up to 6,800,000 Shares of Common Stock Series 2 Warrants to Purchase up to 6,800,000 Shares of Common Stock SCYNEXIS, Inc. Common Stock EQUITY UNDERWRITING AGREEMENT December 17, 2020 Guggenheim Se

December 18, 2020 8-K

Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 17, 2020 SCYNEXIS, Inc.

December 18, 2020 EX-4.2

Form of Series 1 and Series 2 Warrant

Exhibit 4.2 PURSUANT TO THE TERMS OF SECTION 1 OF THIS WARRANT, ALL OR A PORTION OF THIS WARRANT MAY HAVE BEEN EXERCISED OR CANCELED, AND THEREFORE THE ACTUAL NUMBER OF WARRANT SHARES REPRESENTED BY THIS WARRANT MAY BE LESS THAN THE AMOUNTS SET FORTH ON THE FACE HEREOF. ANY TRANSFEREE OF THIS WARRANT SHOULD CONTACT SCYNEXIS, INC. IN ADVANCE OF ACQUIRING THIS WARRANT TO BE APPRISED OF THE ACTUAL NU

December 17, 2020 424B5

8,340,000 Shares Common Stock Pre-Funded Warrants to Purchase 5,260,000 Shares of Common Stock Common Warrants to Purchase up to 13,600,000 Shares of Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-248751 PROSPECTUS SUPPLEMENT (To Prospectus dated October 1, 2020) 8,340,000 Shares Common Stock Pre-Funded Warrants to Purchase 5,260,000 Shares of Common Stock Common Warrants to Purchase up to 13,600,000 Shares of Common Stock We are offering shares of our common stock. Each investor will also receive a warrant to purchase 0.5 of a share

December 16, 2020 424B5

Common Stock Pre-Funded Warrants to Purchase Shares of Common Stock Common Warrants to Purchase up to Shares of Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-248751 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been declared effective by the Securities and Exchange Commission. This preliminary prospectus supplement is not an offer to sell nor does it seek an offer to buy these securities in a

December 8, 2020 8-K

- 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 2, 2020 SCYNEXIS, Inc.

November 6, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEX

October 2, 2020 424B5

$50,000,000 Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-248751 PROSPECTUS $50,000,000 Common Stock We have entered into a Controlled Equity OfferingSM Sales Agreement, or Cantor sales agreement, with Cantor Fitzgerald & Co., or Cantor Fitzgerald, and a Controlled Equity OfferingSM Sales Agreement, or Ladenburg sales agreement, with Ladenburg Thalmann & Co. Inc., or Ladenburg Thalmann, relating to

October 2, 2020 424B5

$200,000,000 Common Stock Preferred Stock Debt Securities

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-248751 $200,000,000 Common Stock Preferred Stock Debt Securities Warrants From time to time, we may offer and sell up to an aggregate amount of $200,000,000 any combination of the securities described in this prospectus, either individually or in combination. We may also offer common stock or preferred stock upon conversion of debt securitie

September 28, 2020 CORRESP

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SCYNEXIS, Inc. 1 Evertrust Plaza, 13th Floor Jersey City, New Jersey 07302-6548 September 28, 2020 Via Email and Edgar U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Mail Stop 3720 Washington, D.C. 20549 Attn: Abby Adams RE: SCYNEXIS, Inc. Registration Statement on Form S-3 File No. 333-248751 Ladies and Gentlemen: SCYNEXIS, Inc. (the “Registrant”) hereb

September 11, 2020 EX-1.3

Controlled Equity OfferingSM Sales Agreement, dated September 11, 2020, by and between the Company and Ladenburg Thalmann & Co. Inc.

EX-1.3 3 scyx-ex137.htm EX-1.3 Exhibit 1.3 SCYNEXIS, INC. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement September 11, 2020 Ladenburg Thalmann & Co. Inc. 277 Park Avenue, 26th Floor New York, New York 10172 Ladies and Gentlemen: SCYNEXIS, Inc. (the “Company”), confirms its agreement (this “Agreement”) with Ladenburg Thalmann & Co. Inc. (“Ladenburg”

September 11, 2020 EX-1.2

Controlled Equity OfferingSM Sales Agreement, dated September 11, 2020, by and between the Company and Cantor Fitzgerald & Co.

EX-1.2 2 scyx-ex126.htm EX-1.2 Exhibit 1.2 SCYNEXIS, INC. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement September 11, 2020 Cantor Fitzgerald & Co. 499 Park Avenue New York, NY 10022 Ladies and Gentlemen: SCYNEXIS, Inc. (the “Company”), confirms its agreement (this “Agreement”) with Cantor Fitzgerald & Co. (“Cantor”), as follows: 1.Issuance and Sal

September 11, 2020 S-3

- S-3

As filed with the Securities and Exchange Commission on September 11, 2020 Registration No.

August 10, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS, I

August 10, 2020 EX-10.4

SCYNEXIS, Inc. 2014 Employee Stock Purchase Plan, as amended and restated. (Filed with the SEC as Exhibit 10.4 to our Quarterly Report on Form 10-Q, filed with the SEC on August 10, 2020, SEC File No. 333-196007, and incorporated by reference here).

Exhibit 10.4 SCYNEXIS, INC. 2014 EMPLOYEE STOCK PURCHASE PLAN ADOPTED BY THE BOARD OF DIRECTORS: February 11, 2014 APPROVED BY THE STOCKHOLDERS: February 25, 2014 Adjusted for Reverse Stock Split: July 17, 2020 1. GENERAL; PURPOSE. (a) The Plan provides a means by which Eligible Employees of the Company and certain designated Related Corporations may be given an opportunity to purchase shares of C

August 10, 2020 EX-10.1

SCYNEXIS, Inc. Amended and Restated Stock Plan

Exhibit 10.1 SCYNEXIS, INC. STOCK OPTION PLAN, AS AMENDED AND RESTATED RE-ADOPTED BY THE BOARD OF DIRECTORS: June 18, 2014 APPROVED BY THE STOCKHOLDERS: September 11, 2014 ADJSTED FOR REVERSE STOCK SPLIT: July 17, 2020 1. Purpose. The SCYNEXIS, Inc. Stock Option Plan, as amended and restated (the “Plan”) is established to create an additional incentive for key employees, directors and consultants

August 10, 2020 EX-10.3

SCYNEXIS, Inc. 2014 Equity Incentive Plan, as amended and restated, (Filed with the SEC as Exhibit 10.3 to our Quarterly Report on Form 10-Q, filed with the SEC on August 10, 2020, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.3 SCYNEXIS, INC. 2014 EQUITY INCENTIVE PLAN, AS AMENDED ADOPTED BY THE BOARD OF DIRECTORS: February 11, 2014 APPROVED BY THE STOCKHOLDERS: February 25, 2014 AS AMENDED BY THE BOARD OF DIRECTORS: June 18, 2014 AS APPROVED BY THE STOCKHOLDERS: September 11, 2014 AS AMENDED BY THE BOARD OF DIRECTORS: March 26, 2015 AS APPROVED BY THE STOCKHOLDERS: , 2015 EFFECTIVE DATE: May 2, 2014 Adjuste

August 10, 2020 EX-10.5

SCYNEXIS, Inc. Amended and Restated 2015 Inducement Plan

Exhibit 10.5 SCYNEXIS, INC. 2015 INDUCEMENT AWARD PLAN ADOPTED: March 26, 2015 Amended: June 9, 2019 ADJUSTED FOR REVERSE STOCK SPLIT: July 17, 2020 1. GENERAL. (a) Eligible Award Recipients. The persons eligible to receive Stock Awards are Eligible Employees as of the date of grant. (b) Available Awards. The Plan provides for the grant of the following Stock Awards: (i) Options, (ii) Stock Apprec

August 10, 2020 EX-10.2

SCYNEXIS, Inc. Amended and Restated 2009 Stock Option Plan

Exhibit 10.2 SCYNEXIS, INC. 2009 STOCK OPTION PLAN ADJUSTED FOR RESERVE STOCK SPLIT: July 17, 2020 1. Purpose The purpose of this 2009 Stock Option Plan (the “Plan”) of SCYNEXIS, Inc., a Delaware corporation (the “Company”), is to advance the interests of the Company’s stockholders by enhancing the Company’s ability to attract, retain and motivate persons who are expected to make important contrib

August 4, 2020 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 3, 2020 SCYNEXIS, Inc.

July 16, 2020 EX-3.1

Certificate of Amendment of Amended and Restated Certificate of Incorporation of SCYNEXIS, Inc. (Filed with the SEC as Exhibit 3.1 to our Form 8-K, filed with the SEC on July 16, 2020, SEC File No. 001-36365, and incorporated by reference here).

EX-3.1 2 scyx-ex316.htm EX-3.1 Exhibit 3.1 CERTIFICATE OF AMENDMENT OF AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF SCYNEXIS, Inc. SCYNEXIS, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Corporation”), hereby certifies that: First: The name of the Corporation is SCYNEXIS, Inc. The Corporation was originally inco

July 16, 2020 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 16, 2020 SCYNEXIS, Inc.

July 7, 2020 8-K

Submission of Matters to a Vote of Security Holders

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 2, 2020 SCYNEXIS, Inc.

May 29, 2020 DEF 14A

- DEF 14A

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permi

May 15, 2020 PRE 14A

- PRE 14A

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permit

May 11, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS,

May 11, 2020 424B3

19,386,000 Shares Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-237952 Prospectus 19,386,000 Shares Common Stock This prospectus relates to the sale or other disposition from time to time of up to 19,386,000 shares of our common stock issuable pursuant to convertible senior notes that may convert into up to an aggregate of 19,386,000 shares of our common stock, to be sold by the selling stockholder named in

May 7, 2020 CORRESP

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SCYNEXIS, Inc. 1 Evertrust Plaza, 13th Floor Jersey City, New Jersey 07302-6548 May 7, 2020 Via Email and Edgar U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Mail Stop 3720 Washington, D.C. 20549 Attn: Alan Campbell RE: SCYNEXIS, Inc. Registration Statement on Form S-3 File No. 333-237952 Ladies and Gentlemen: SCYNEXIS, Inc. (the “Registrant”) hereby re

May 1, 2020 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 1, 2020 SCYNEXIS, Inc.

May 1, 2020 S-3

- S-3

As filed with the Securities and Exchange Commission on May 1, 2020 Registration No.

April 28, 2020 10-K/A

Annual Report - 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED December 31, 2019 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-3

April 28, 2020 EX-10.24

Non-Employee Director Compensation Arrangements

EX-10.24 2 scyx-ex1024104.htm EX-10.24 Exhibit 10.24 Our non-employee directors are compensated in accordance with the following policy: Each non-employee director receives an annual base cash retainer of $35,000 for such service, to be paid quarterly. In addition, the chairman of the Board receives an additional annual base cash retainer of $28,000, to be paid quarterly. In addition, each member

April 24, 2020 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 21, 2020 SCYNEXIS, Inc.

April 21, 2020 EX-99.1

SCYNEXIS Announces Positive Top-Line Results from its Second Pivotal Phase 3 Study (VANISH-306) of Oral Ibrexafungerp for the Treatment of Vulvovaginal Candidiasis (Vaginal Yeast Infection)

EX-99.1 2 d895609dex991.htm EX-99.1 Exhibit 99.1 SCYNEXIS Announces Positive Top-Line Results from its Second Pivotal Phase 3 Study (VANISH-306) of Oral Ibrexafungerp for the Treatment of Vulvovaginal Candidiasis (Vaginal Yeast Infection) Published: Apr 21, 2020 • Ibrexafungerp achieved highly statistically significant superiority over placebo for the primary and key secondary study endpoints • Ib

April 21, 2020 8-K

Financial Statements and Exhibits, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 21, 2020 SCYNEXIS, Inc.

April 13, 2020 EX-4.1

Registration Rights Agreement, dated April 10, 2020, between SCYNEXIS, Inc. and Aspire Capital Fund, LLC

EX-4.1 2 scyx-ex418.htm EX-4.1 Exhibit 4.1 REGISTRATION RIGHTS AGREEMENT REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of April 10, 2020, by and between SCYNEXIS, INC., a Delaware corporation (the “Company”), and ASPIRE CAPITAL FUND, LLC, an Illinois limited liability company (together with its permitted assigns, the “Buyer”). Capitalized terms used herein and not otherwise defined he

April 13, 2020 EX-10.1

Common Stock Purchase Agreement, dated April 10, 2020, between SCYNEXIS, Inc. and Aspire Capital Fund, LLC (Filed with the SEC as Exhibit 10.1 to our Form 8-K, filed with the SEC on April 13, 2020, SEC File No. 001-36365, and incorporated by reference here).

EX-10.1 4 scyx-ex1017.htm EX-10.1 Exhibit 10.1 COMMON STOCK PURCHASE AGREEMENT COMMON STOCK PURCHASE AGREEMENT (the “Agreement”), dated as of April 10, 2020 by and between SCYNEXIS, INC., a Delaware corporation (the “Company”), and ASPIRE CAPITAL FUND, LLC, an Illinois limited liability company (the “Buyer”). Capitalized terms used herein and not otherwise defined herein are defined in Section 10

April 13, 2020 424B5

$20,000,000 of Common Stock plus 709,103 Commitment Shares Common Stock

Table of Contents As Filed Pursuant to Rule 424(b)(5) Registration No. 333-227167 PROSPECTUS SUPPLEMENT (To Prospectus dated September 14, 2018) $20,000,000 of Common Stock plus 709,103 Commitment Shares Common Stock Pursuant to this prospectus supplement and the accompanying prospectus, we are offering up to $20.0 million aggregate amount plus 709,103 shares of our common stock, par value $0.001

April 13, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 10, 2020 SCYNEXIS, Inc.

April 9, 2020 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 9, 2020 SCYNEXIS, Inc. (Exact name of registrant as specified in its charter) Delaware 001-36365 56-2181648 (State or other jurisdiction of incorporation) (Commission File Numbe

April 9, 2020 EX-10.1

Senior Convertible Note Purchase Agreement, dated as of April 9, 2020, among SCYNEXIS, Inc., as Issuer, Puissance Life Science Opportunities Fund IV, as the Investor, (including the form of Note attached thereto as Exhibit A). (Filed with the SEC as Exhibit 10.1 to our Form 8-K, filed with the SEC on April 9, 2020, SEC File No. 001-36365, and incorporated by reference here).

EX-10.1 2 scyx-ex10114.htm EX-10.1 Exhibit 10.1 EXECUTION VERSION SCYNEXIS, INC., as Issuer, AND Puissance Life Science Opportunities Fund VI, as the Investor Senior Convertible Note Purchase Agreement Dated as of April 9, 2020 6.0% Convertible Senior Notes due 2026 ARTICLE 1. DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION 1 Section 1.01 Definitions 1 Section 1.02 Acts of Holder; Record D

March 11, 2020 10-K

Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED December 31, 2019 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS, Inc.

March 11, 2020 S-8

SCYX / SCYNEXIS, Inc. S-8 - - S-8

As filed with the Securities and Exchange Commission on March 11, 2020 Registration No.

March 11, 2020 EX-4.2

Exhibit 4.2

EX-4.2 2 scyx-ex42253.htm EX-4.2 Exhibit 4.2 SCYNEXIS, INC. DESCRIPTION OF COMMON STOCK SCYNEXIS, Inc. (“we,” “our,” “us,” or the “Company,”) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”): our common stock. The following description of our common stock does not purport to be complete and is subject in all respects to

February 14, 2020 SC 13G/A

SCYX / SCYNEXIS, Inc. / CAXTON CORP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 14, 2020 SC 13G/A

SCYX / SCYNEXIS, Inc. / FEDERATED INVESTORS INC /PA/ Passive Investment

OMB APPROVAL OMB Number: 3235-0145 Estimated average burden hours per response ….11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5*) SCYNEXIS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 811292101 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statem

February 14, 2020 SC 13G/A

SCYX / SCYNEXIS, Inc. / Puissance Life Science Opportunities Fund Vi Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.1) * Scynexis, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 811292101 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

December 23, 2019 SC 13G

SCYX / SCYNEXIS, Inc. / Decheng Capital China Life Sciences Usd Fund Iii, L.p. - SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* SCYNEXIS, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 811292101 (CUSIP Number) December 12, 2019 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule purs

December 20, 2019 SC 13G

SCYX / SCYNEXIS, Inc. / ARMISTICE CAPITAL, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

December 16, 2019 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 13, 2019 SCYNEXIS, Inc. (Exact name of registrant as specified in its charter) Delaware 001-36365 56-2181648 (State or other jurisdiction of incorporation) (Commission File N

December 12, 2019 EX-4.1

Form of Warrant

EX-4.1 3 d839015dex41.htm EX-4.1 Exhibit 4.1 SERIES 1 COMMON STOCK PURCHASE WARRANT SCYNEXIS, INC. Warrant Shares: Issue Date: December 12, 2019 Initial Exercise Date: , 2019 THIS SERIES 1 COMMON STOCK PURCHASE WARRANT (the “Warrant”) of SCYNEXIS, Inc., a Delaware corporation (the “Company”), certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject

December 12, 2019 8-K

Financial Statements and Exhibits, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 10, 2019 SCYNEXIS, Inc. (Exact name of registrant as specified in its charter) Delaware 001-36365 56-2181648 (State or other jurisdiction of incorporation) (Commission Fi

December 12, 2019 EX-1.1

Underwriting Agreement, dated December 10, 2019, by and between the Company and H.C. Wainwright & Co., LLC, as representative of the several underwriters named on Schedule I thereto

EX-1.1 Exhibit 1.1 Execution Version 38,888,889 Shares of Common Stock ($0.001 Par Value) Warrants to Purchase up to 38,888,889 Shares of Common Stock SCYNEXIS, Inc. Common Stock UNDERWRITING AGREEMENT December 10, 2019 H.C. Wainwright & Co., LLC As Representative of the several Underwriters named in Schedule I attached hereto c/o H.C. Wainwright & Co., LLC 430 Park Avenue New York, New York 10022

December 11, 2019 424B5

38,888,889 Shares Common Stock Warrants to Purchase up to 38,888,889 Shares of Common Stock

424B5 Table of Contents As Filed Pursuant to Rule 424(b)(5) Registration No. 333-227167 PROSPECTUS SUPPLEMENT (To Prospectus dated September 14, 2018) 38,888,889 Shares Common Stock Warrants to Purchase up to 38,888,889 Shares of Common Stock We are offering shares of our common stock. Each investor will also receive a warrant to purchase one share of our common stock at an exercise price of $1.10

December 9, 2019 424B5

Common Stock Warrants to Purchase up to Shares of Common Stock

424B5 Table of Contents As Filed Pursuant to Rule 424(b)(5) Registration No. 333-227167 The information in this preliminary prospectus supplement is not complete and may be changed. This preliminary prospectus supplement is not an offer to sell nor does it seek an offer to buy these securities in any jurisdiction where the offer or sale is not permitted. PROSPECTUS SUPPLEMENT (Subject to Completio

November 12, 2019 10-Q

Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2019 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEX

August 7, 2019 S-8

SCYX / SCYNEXIS, Inc. S-8 - - S-8

As filed with the Securities and Exchange Commission on August 7, 2019 Registration No.

August 7, 2019 EX-3.2

Certificate of Amendment of Amended and Restated Certificate of Incorporation of SCYNEXIS, Inc. (Filed with the SEC as Exhibit 3.2 to our Form 10-Q, filed with the SEC on August 7, 2019, SEC File No. 001-36365, and incorporated by reference here).

EX-3.2 2 scyx-ex3242.htm EX-3.2 Exhibit 3.2 CERTIFICATE OF AMENDMENT OF AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF SCYNEXIS, Inc. SCYNEXIS, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Corporation”), hereby certifies that: First: The name of the Corporation is SCYNEXIS, Inc. The Corporation was originally inc

August 7, 2019 10-Q

Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2019 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36365 SCYNEXIS, I

August 7, 2019 EX-10.1

SCYNEXIS, Inc. Amended and Restated 2015 Inducement Award Plan. (Filed with the SEC as Exhibit 10.1 to our Quarterly Report on Form 10-Q, filed with the SEC on August 7, 2019, SEC File No. 001-36365, and incorporated by reference here).

Exhibit 10.1 SCYNEXIS, INC. 2015 INDUCEMENT AWARD PLAN ADOPTED: March 26, 2015 Amended: June 9, 2019 1. GENERAL. (a) Eligible Award Recipients. The persons eligible to receive Stock Awards are Eligible Employees as of the date of grant. (b) Available Awards. The Plan provides for the grant of the following Stock Awards: (i) Options, (ii) Stock Appreciation Rights (iii) Restricted Stock Awards, (iv

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