MPW / Medical Properties Trust, Inc. - SEC Filings, Annual Report, Proxy Statement

Medical Properties Trust, Inc.
US ˙ NYSE ˙ US58463J3041

Basic Stats
LEI 254900U6E39J1MQCCY14
CIK 1287865
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Medical Properties Trust, Inc.
SEC Filings (Chronological Order)
This page provides a complete, chronological list of SEC Filings, excluding ownership filings which we provide elsewhere.
August 14, 2025 EX-1.1

MEDICAL PROPERTIES TRUST, INC. Shares of Common Stock (par value $0.001 per share) EQUITY DISTRIBUTION AGREEMENT

EX-1.1 Exhibit 1.1 MEDICAL PROPERTIES TRUST, INC. $500,000,000 Shares of Common Stock (par value $0.001 per share) EQUITY DISTRIBUTION AGREEMENT August 11, 2025 Truist Securities, Inc. Truist Securities, Inc. Truist Bank Barclays Capital Inc. Barclays Capital Inc. Barclays Bank PLC BNP Paribas Securities Corp. BNP Paribas Securities Corp. BNP PARIBAS BofA Securities, Inc. BofA Securities, Inc. Ban

August 14, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 11, 2025 MEDICAL PROPERTIE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 11, 2025 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in its Charter) Maryland Delaware 001-32559 333-177186 20-0191742

August 11, 2025 EX-FILING FEES

Security Type

Calculation of Filing Fee Tables S-3 MEDICAL PROPERTIES TRUST INC Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial Effective Date Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees to be Paid 1 Equity Common Stock, $0.

August 11, 2025 424B5

$500,000,000 Common Stock

424B5 Filed Pursuant to Rule 424(b)(5) Registration No. 333-287726 PROSPECTUS SUPPLEMENT (To Prospectus dated June 2, 2025) $500,000,000 Common Stock We have entered into an equity distribution agreement for a continuous offering program with Truist Securities, Inc., Barclays Capital Inc., BNP Paribas Securities Corp., BofA Securities, Inc., Citizens JMP Securities, LLC, Credit Agricole Securities

August 11, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 11, 2025 MEDICAL PROPERTIE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 11, 2025 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Numb

August 11, 2025 EX-99.1

U.S. FEDERAL INCOME TAX CONSIDERATIONS

EX-99.1 Exhibit 99.1 U.S. FEDERAL INCOME TAX CONSIDERATIONS This section summarizes the current material federal income tax consequences to Medical Properties and the Operating Partnership generally resulting from the treatment of Medical Properties as a REIT. Because this section is a general summary, it does not address all of the potential tax issues that may be relevant to you in light of your

August 8, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file number

July 31, 2025 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS AND UPDATE Rapid Growth in Cash Rents from New Operators Recent Transactions Continue to Validate Asset Values and Provide Balance Sheet Flexibility

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Head of Financial Strategy and Investor Relations Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS AND UPDATE Rapid Growth in Cash Rents from New Operators Recent Transactions Continue to Validate Asset Values and Provide Balance Sheet Flexibility Birmingham, AL –

July 31, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 31, 2025 MEDICAL PROPERTIES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 31, 2025 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of in

July 31, 2025 EX-99.2

QUARTERLY SUPPLEMENTAL 2Q 2025 AT T H E V E R Y H E A R T O F H E A LT H C A R E .®

EX-99.2 QUARTERLY SUPPLEMENTAL 2Q 2025 AT T H E V E R Y H E A R T O F H E A LT H C A R E .® Exhibit 99.2 COMPANY OVERVIEW FORWARD-LOOKING STATEMENTS 3 This press release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section Company Information 3 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements

June 3, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2025 MEDICAL PROPERTIES T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2025 MEDICAL PROPERTIES TRUST, INC. (Exact name of Registrant as Specified in Its Charter) Maryland 001-32559 20-0191742 (State or Other Jurisdiction of Incorporation) (Commis

June 2, 2025 S-3ASR

As filed with the Securities and Exchange Commission on June 2, 2025

Table of Contents As filed with the Securities and Exchange Commission on June 2, 2025 Registration No.

June 2, 2025 EX-FILING FEES

Calculation of Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-3 (Form Type) Medical Properties Trust, Inc.

June 2, 2025 EX-25.1

Statement of Eligibility on Form T-1

Exhibit 25.1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 ☐ Check if an Application to Determine Eligibility of a Trustee Pursuant to Section 305(b)(2) WILMINGTON TRUST, NATIONAL ASSOCIATION (Exact name of trustee as specified in its charter) 16-1486454 (I.R.S. employer identification no.) 1100 North Market Street Wilmington, DE 19890-0001 (Address of principal

May 20, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒       Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for

May 9, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file numbe

May 1, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 1, 2025 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of inco

May 1, 2025 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS Results Consistent with Expectations Following Mid-Quarter Debt Refinancing

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Head of Financial Strategy and Investor Relations Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS Results Consistent with Expectations Following Mid-Quarter Debt Refinancing Birmingham, AL – May 1, 2025 – Medical Properties Trust, Inc. (the “Company” or “MPT”) (NY

May 1, 2025 EX-99.2

QUARTERLY SUPPLEMENTAL 1Q 2025 AT T H E V E R Y H E A R T O F H E A LT H C A R E .®

Exhibit 99.2 QUARTERLY SUPPLEMENTAL 1Q 2025 AT T H E V E R Y H E A R T O F H E A LT H C A R E .® COMPANY OVERVIEW FORWARD-LOOKING STATEMENTS 3 This press release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section Company Information 3 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements can gene

April 17, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of

April 17, 2025 DEF 14A

Dear Fellow Stockholder:

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confid

March 3, 2025 EX-21.1

Subsidiaries of Medical Properties Trust, Inc.

Exhibit 21.1 SUBSIDIARIES OF REGISTRANT Subsidiaries Jurisdiction of Organization Jurisdiction(s) in Which Qualified as a Foreign Corporation Medical Properties Trust, LLC Delaware Alabama, Massachusetts Mountain View-MPT Hospital, LLC Delaware Idaho MPT of Altoona, LLC Delaware Wisconsin MPT of Alvin FCER, LLC Delaware Texas MPT Bath S.a.r.l. Luxembourg — MPT of Bayonne, LLC Delaware New Jersey M

March 3, 2025 EX-4.11

Twentieth Supplemental Indenture, dated as of February 28, 2025, among MPT Springstone REIT, Inc., as subsidiary guarantor, and MPT Operating Partnership, L.P. and MPT Finance Corporation, as issuers, Medical Properties Trust, Inc., as parent and guarantor, and Wilmington Trust, National Association, as trustee

Exhibit 4.11 Twentieth Supplemental Indenture (this “Supplemental Indenture”), dated as of February 28, 2025, among MPT Springstone REIT, Inc. (the “Guaranteeing Subsidiary”), a subsidiary of MPT Operating Partnership L.P., a Delaware limited partnership (“Opco”), Opco, MPT Finance Corporation (“Finco” and, together with Opco, the “Issuers”), Medical Properties Trust, Inc., a Maryland corporation

March 3, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file

February 27, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 27, 2025 MEDICAL PROPERT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 27, 2025 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction o

February 27, 2025 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FOURTH QUARTER AND FULL-YEAR RESULTS Completed Approximately $5.5 Billion of Asset Monetization Transactions, Including February’s $2.5 Billion Senior Secured Notes Offering That Addresses All Debt Maturities Th

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Head of Financial Strategy and Investor Relations Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FOURTH QUARTER AND FULL-YEAR RESULTS Completed Approximately $5.5 Billion of Asset Monetization Transactions, Including February’s $2.5 Billion Senior Secured Notes Offering That A

February 27, 2025 EX-99.2

3 COMPANY OVERVIEWCompany Information 3FINANCIAL INFORMATION6 Reconciliation of Funds from Operations 6 Debt Summary 7 Debt Maturities and Debt Metrics 8PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 99 Total Assets and Revenues by Asset Type

EX-99.2 Exhibit 99.2 Exhibit 99.2 QUARTERLY SUPPLEMENTAL4Q 2024 3 COMPANY OVERVIEWCompany Information 3FINANCIAL INFORMATION6 Reconciliation of Funds from Operations 6 Debt Summary 7 Debt Maturities and Debt Metrics 8PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 99 Total Assets and Revenues by Asset Type, Operator, State and Country 10 Rent Coverage 13 Summary of Acquisitions, Active Deve

February 18, 2025 EX-4.1

Indenture, dated as of February 13, 2025, among Medical Properties Trust, Inc., MPT Operating Partnership, L.P., MPT Finance Corporation, the subsidiary guarantors party thereto, Wilmington Trust, National Association, as trustee, dollar paying agent, dollar registrar, dollar transfer agent and notes collateral agent, and U.S. Bank Europe DAC, as euro paying agent, euro registrar and euro transfer agent

Exhibit 4.1 INDENTURE Dated as of February 13, 2025 Among MPT OPERATING PARTNERSHIP, L.P. and MPT FINANCE CORPORATION, as the Issuers, and MEDICAL PROPERTIES TRUST, INC., as Parent and a Guarantor, and SUBSIDIARIES PARTY HERETO, as Subsidiary Guarantors, and WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee, Dollar Paying Agent, Dollar Registrar, Dollar Transfer Agent and Notes Collateral Agent,

February 18, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 13, 2025 MEDICAL PROPERT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 13, 2025 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Nu

February 18, 2025 EX-10.1

Amendment No. 3 to Second Amended and Restated Revolving Credit and Term Loan Agreement, dated as of February 13, 2025, by and among Medical Properties Trust, Inc., MPT Operating Partnership, L.P., the Guarantors party hereto, the several lenders from time to time party thereto, and JPMorgan Chase Bank, N.A., as administrative agent

Exhibit 10.1 AMENDMENT NO. 3 TO SECOND AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT This AMENDMENT NO. 3 TO SECOND AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT, dated as of February 13, 2025 (this “Amendment No. 3”), is by and among MEDICAL PROPERTIES TRUST, INC., a Maryland corporation (“Holdings”), MPT OPERATING PARTNERSHIP, L.P., a Delaware limited partnership

January 31, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 30, 2025 MEDICAL PROPERTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 30, 2025 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Num

January 31, 2025 EX-99.1

MEDICAL PROPERTIES TRUST ANNOUNCES PRICING OF $1.5 BILLION 8.500% SENIOR SECURED NOTES DUE 2032 AND €1.0 BILLION 7.000% SENIOR SECURED NOTES DUE 2032 Pricing Represents a Blended Coupon of 7.885%

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Head of Financial Strategy and Investor Relations Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST ANNOUNCES PRICING OF $1.5 BILLION 8.500% SENIOR SECURED NOTES DUE 2032 AND €1.0 BILLION 7.000% SENIOR SECURED NOTES DUE 2032 Pricing Represents a Blended Coupon of 7.885% Birmingham, AL – Januar

January 29, 2025 EX-99.1

Recent Developments

EX-99.1 Exhibit 99.1 Recent Developments Disposition and Recovery Transactions During the year ended December 31, 2024, we strategically disposed of properties and received insurance proceeds aggregating approximately $2.0 billion, as further detailed below, and realized net real estate gains of approximately $570 million. On April 9, 2024, we completed the sale of five properties to Prime Healthc

January 29, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 29, 2025 MEDICAL PROPERTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 29, 2025 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Num

January 29, 2025 EX-99.2

# # #

EX-99.2 Exhibit 99.2 Contact: Drew Babin, CFA, CMA Head of Financial Strategy and Investor Relations Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST ANNOUNCES PRIVATE OFFERING OF SENIOR SECURED NOTES Birmingham, AL – January 29, 2025 – Medical Properties Trust, Inc. (the “Company” or “MPT”) (NYSE: MPW) today announced that its operating part

November 13, 2024 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q/A (Amendment No.1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q/A (Amendment No.1) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-3255

November 13, 2024 EX-10.1

Amendment No. 2 to Second Amended and Restated Revolving Credit and Term Loan Agreement, dated as of August 6, 2024, by and among Medical Properties Trust, Inc., MPT Operating Partnership, L.P., the Guarantors party hereto, the several lenders from time to time party thereto, and JPMorgan Chase Bank, N.A., as administrative agent

Exhibit 10.1 AMENDMENT NO. 2 TO SECOND AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT This AMENDMENT NO. 2 TO SECOND AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT, dated as of August 6, 2024 (this “Amendment No. 2”), is by and among MEDICAL PROPERTIES TRUST, INC., a Maryland corporation (“Holdings”), MPT OPERATING PARTNERSHIP, L.P., a Delaware limited partnership (th

November 12, 2024 EX-10.1

Amendment No. 2 to Second Amended and Restated Revolving Credit and Term Loan Agreement, dated as of August 6, 2024, by and among Medical Properties Trust, Inc., MPT Operating Partnership, L.P., the Guarantors party hereto, the several lenders from time to time party thereto, and JPMorgan Chase Bank, N.A., as administrative agent

Exhibit 10.1 AMENDMENT NO. 2 TO SECOND AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT This AMENDMENT NO. 2 TO SECOND AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT, dated as of August 6, 2024 (this “Amendment No. 2”), is by and among MEDICAL PROPERTIES TRUST, INC., a Maryland corporation (“Holdings”), MPT OPERATING PARTNERSHIP, L.P., a Delaware limited partnership (th

November 12, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file n

November 7, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 7, 2024 MEDICAL PROPERTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 7, 2024 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of

November 7, 2024 EX-99.2

Medical Properties Trust QUARTERLY SUPPLEMENTAL 3Q 2024

Exhibit 99.2 Medical Properties Trust QUARTERLY SUPPLEMENTAL 3Q 2024 3 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION 6 Reconciliation of Funds from Operations 6 Debt Summary 7 Debt Maturities and Debt Metrics 8 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 9 9 Total Assets and Revenues by Asset Type, Operator, State and Country 10 Rent Coverage 13 Summary of Investments and

November 7, 2024 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS THIRD QUARTER RESULTS Operations of 17 Former Steward Hospitals Transitioned to Five New Operators Approximately $2.9 Billion of Year-to-Date Liquidity Transactions Completed

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Head of Financial Strategy and Investor Relations Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS THIRD QUARTER RESULTS Operations of 17 Former Steward Hospitals Transitioned to Five New Operators Approximately $2.9 Billion of Year-to-Date Liquidity Transactions Completed Birmi

September 17, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 11, 2024 MEDICAL PROPER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 11, 2024 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File N

August 9, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file number

August 9, 2024 EX-10.1

Amendment No. 1 to Second Amended and Restated Revolving Credit and Term Loan Agreement, dated as of April 12, 2024, by and among Medical Properties Trust, Inc., MPT Operating Partnership, L.P., the Guarantors party hereto, the several lenders from time to time party thereto, and JPMorgan Chase Bank, N.A., as administrative agent

Exhibit 10.1 AMENDMENT NO. 1 TO SECOND AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT This AMENDMENT NO. 1 TO SECOND AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT, dated as of April 12, 2024 (this “Amendment No. 1”), is by and among MEDICAL PROPERTIES TRUST, INC., a Maryland corporation (“Holdings”), MPT OPERATING PARTNERSHIP, L.P., a Delaware limited partnership (th

August 8, 2024 EX-99.2

QUARTERLY SUPPLEMENTAL 2Q 2024

EX-99.2 Exhibit 99.2 QUARTERLY SUPPLEMENTAL 2Q 2024 Pictured above: Klinik am Burggraben—Bad Salzuflen, Germany—Operated by MEDIAN. On the cover: Málaga Center of Excellence—Málaga, Spain—Operated by GenesisCare. FORWARD-LOOKING STATEMENTS This press release includes forward-looking statements within the meaning COMPANY OVERVIEW of Section 27A of the Securities Act of 1933, as amended, and Section

August 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 8, 2024 MEDICAL PROPERTIES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 8, 2024 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Numbe

August 8, 2024 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS Successfully Executed More than $2.5 Billion in Year-to-Date Liquidity Transactions Modified Credit Facility Terms and Conditions

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Head of Financial Strategy and Investor Relations Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS Successfully Executed More than $2.5 Billion in Year-to-Date Liquidity Transactions Modified Credit Facility Terms and Conditions Birmingham, AL – August 8, 2024 – M

June 3, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 30, 2024 MEDICAL PROPERTIES T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 30, 2024 MEDICAL PROPERTIES TRUST, INC. (Exact name of Registrant as Specified in Its Charter) Maryland 001-32559 20-0191742 (State or Other Jurisdiction of Incorporation) (Commis

May 29, 2024 EX-10.2

Second Amendment to Second Amended and Restated Master Lease Agreement between certain subsidiaries of MPT Operating Partnership, L.P. as Lessor and certain subsidiaries of Steward Health Care System LLC, Lessee

Exhibit 10.2 AMENDMENT TO SECOND AMENDED AND RESTATED MASTER LEASE AGREEMENT (2024 Bridge Loan and Second Forbearance Agreement) THIS AMENDMENT TO SECOND AMENDED AND RESTATED MASTER LEASE AGREEMENT (this “Amendment”), dated February 21, 2024, is by and among certain Affiliates of MPT OPERATING PARTNERSHIP, L.P., a Delaware limited partnership (“MPT”), as further described on the signature pages he

May 29, 2024 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 9, 2024 M

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 9, 2024 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Maryland 001-32559 20-0191742 (State or other jurisdiction of incorpo

May 29, 2024 EX-10.1

Amendment to Second Amended and Restated Master Lease Agreement between certain subsidiaries of MPT Operating Partnership, L.P. as Lessor and certain subsidiaries of Steward Health Care System LLC, Lessee

Exhibit 10.1 AMENDMENT TO SECOND AMENDED AND RESTATED MASTER LEASE AGREEMENT (Stewardship Note) THIS AMENDMENT TO SECOND AMENDED AND RESTATED MASTER LEASE AGREEMENT (this “Amendment”), dated January 2, 2024, is by and among certain Affiliates of MPT OPERATING PARTNERSHIP, L.P., a Delaware limited partnership (“MPT”), as further described on the signature pages hereto (collectively, jointly and sev

May 29, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file numbe

May 29, 2024 EX-99.1

QUARTERLY SUPPLEMENTAL 1Q 2024 (UPDATED)

EX-99.1 Exhibit 99.1 QUARTERLY SUPPLEMENTAL 1Q 2024 (UPDATED) No Spacing;MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2024 2 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Funds from Operations 6 Debt Summary 7 Debt Maturities and Debt Metrics 8 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 9 Total Assets and Revenues by Asset Type, Operator, St

May 28, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 21, 2024 MEDICAL PROPERTIES T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 21, 2024 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Number

May 22, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒       Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidenti

May 16, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 16, 2024 MEDICAL PROPERTIES T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 16, 2024 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Number

May 16, 2024 EX-99.1

MEDICAL PROPERTIES TRUST COMMENTS ON DELAYED FORM 10-Q FILING AND RELATED NOTICE FROM NYSE

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST COMMENTS ON DELAYED FORM 10-Q FILING AND RELATED NOTICE FROM NYSE Birmingham, AL – May 16, 2024 – As described in the Form 12b-25 previously filed by Medical Properties Trust, Inc. (the “Company” or

May 13, 2024 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check One):  ☐ Form 10-K  ☐ Form 20-F  ☐ Form 11-K  ☒ Form 10-Q ☐ Form 10-D  ☐ Form N-SAR  ☐ Form N-CSR For Period Ended: March 31, 2024

SEC File Numbers: 001-32559, 333-177186 CUSIP Number: 58463J304 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

May 10, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 6, 2024 MEDICAL PROPERTIES TR

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 6, 2024 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 Dela

May 9, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 9, 2024 MEDICAL PROPERTIES TR

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 9, 2024 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of inco

May 9, 2024 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS Executed Total Liquidity Transactions of $1.6 Billion Year-to-Date, or 80% of MPT’s Initial FY 2024 Target Debt, Net of Cash, Reduced by Approximately $1.6 Billion Since the First Quarter o

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS Executed Total Liquidity Transactions of $1.6 Billion Year-to-Date, or 80% of MPT’s Initial FY 2024 Target Debt, Net of Cash, Reduced by Approximately $1.6

May 9, 2024 EX-99.2

Medical Properties Trust

EX-99.2 Exhibit 99.2 Medical Properties Trust QUARTERLY SUPPLEMENTAL 1Q 2024 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION 6 Reconciliation of Funds from Operations 6 Debt Summary 7 Debt Maturities and Debt Metrics 8 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 9 9 Total Assets and Revenues    by Asset Type, Operator, State and Country 10 Rent Coverage 13 Summary of Invest

May 7, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 6, 2024 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Maryland 001-32559 20-0191742 Delaware 333-177186 20-0242

April 18, 2024 EX-99.1

MEDICAL PROPERTIES TRUST SELLS MAJORITY INTEREST IN UTAH HOSPITALS Generates Approximately $1.1 Billion of Total Cash Proceeds to MPT Brings Total Liquidity Transactions Year-to-Date to $1.6 Billion, or 80% of MPT’s Initial FY 2024 Target

EX-99.1 Exhibit 99.1   Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST SELLS MAJORITY INTEREST IN UTAH HOSPITALS Generates Approximately $1.1 Billion of Total Cash Proceeds to MPT Brings Total Liquidity Transactions Year-to-Date to $1.6 Billion, or 80% of MPT’

April 18, 2024 EX-99.2

MEDICAL PROPERTIES TRUST, INC. AND SUBSIDIARIES MPT OPERATING PARTNERSHIP, L.P. AND SUBSIDIARIES UNAUDITED PRO FORMA CONDENSED CONSOLIDATED FINANCIAL INFORMATION

EX-99.2 Exhibit 99.2 MEDICAL PROPERTIES TRUST, INC. AND SUBSIDIARIES MPT OPERATING PARTNERSHIP, L.P. AND SUBSIDIARIES UNAUDITED PRO FORMA CONDENSED CONSOLIDATED FINANCIAL INFORMATION Joint Venture Transaction These unaudited pro forma condensed consolidated financial statements of Medical Properties Trust, Inc. and subsidiaries, and of MPT Operating Partnership, L.P. and subsidiaries have been pre

April 18, 2024 8-K

Regulation FD Disclosure, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 12, 2024 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Numbe

April 17, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒       Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for

April 17, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒       Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐

March 14, 2024 EX-10.1

Form of Award Agreement for Restricted Stock Units

EX-10.1 Exhibit 10.1 MEDICAL PROPERTIES TRUST, INC. AMENDED AND RESTATED 2019 EQUITY INCENTIVE PLAN AWARD AGREEMENT FOR CASH-SETTLED RESTRICTED STOCK UNITS THIS AWARD AGREEMENT (the “Agreement”) is made effective and entered into with an award grant date as of March 8, 2024 (the “Grant Date”) by and between MEDICAL PROPERTIES TRUST, INC., a Maryland corporation (the “Company”), and (the “Participa

March 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 8, 2024 MEDICAL PROPERTIES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 8, 2024 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of in

February 29, 2024 EX-21.1

Subsidiaries of Medical Properties Trust, Inc.

Exhibit 21.1 SUBSIDIARIES OF REGISTRANT Subsidiaries Jurisdiction of Organization Jurisdiction(s) in Which Qualified as a Foreign Corporation Medical Properties Trust, LLC Delaware Alabama, Massachusetts Mountain View-MPT Hospital, LLC Delaware Idaho MPT of Altoona, LLC Delaware Wisconsin MPT of Alvin FCER, LLC Delaware Texas MPT Bath S.a.r.l. Luxembourg — MPT of Bayonne, LLC Delaware New Jersey M

February 29, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file

February 29, 2024 EX-19.2

Insider Trading Policy

Exhibit 19.2 MEDICAL PROPERTIES TRUST, INC. Insider Trading Policy Revised August 18, 2016 Important: Any director or employee who wishes to trade in the Company's securities must contact the Chief Financial Officer (the "CFO ") for approval prior to making such trade. Background Federal securities laws prohibit (i) buying or selling a company's securities by anyone who is aware of material nonpub

February 29, 2024 EX-19.1

Compensation Recovery Policy

Exhibit 19.1 MEDICAL PROPERTIES TRUST, INC. COMPENSATION RECOVERY POLICY Adopted as of November 9, 2023 Medical Properties Trust, Inc., a Maryland corporation (the “Company”), has adopted a Compensation Recovery Policy (this “Policy”) as described below. This Policy supersedes and replaces the Company’s Clawback Policy adopted in 2013 (the “Prior Policy”) with respect to Incentive-Based Compensati

February 21, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 21, 2024 MEDICAL PROPERT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 21, 2024 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction o

February 21, 2024 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FOURTH QUARTER AND FULL-YEAR RESULTS Accelerated Asset Divestiture Strategy with More Than $480 million of Liquidity Transactions

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FOURTH QUARTER AND FULL-YEAR RESULTS Accelerated Asset Divestiture Strategy with More Than $480 million of Liquidity Transactions Birmingham, AL – February 21, 2024 – Medical Pr

February 21, 2024 EX-99.2

QUARTERLY SUPPLEMENTAL FOURTH QUARTER 2023

EX-99.2 Exhibit 99.2 QUARTERLY SUPPLEMENTAL FOURTH QUARTER 2023 3 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION 6 Reconciliation of Funds from Operations 6 Debt Summary 7 Debt Maturities and Debt Metrics 8 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 9 9 Total Assets and Revenues by Asset Type, Operator, State and Country 10 Rent Coverage 13 Summary of Investments and Deve

February 13, 2024 SC 13G/A

MPW / Medical Properties Trust, Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 18)* Name of issuer: Medical Properties Trust Inc Title of Class of Securities: Common Stock CUSIP Number: 58463J304 Date of Event Which Requires Filing of this Statement: December 29, 2023 Check the appropriate box to designate the rule pursuant to which this Schedule i

February 8, 2024 CORRESP

February 8, 2024

February 8, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporate Finance Office of Real Estate and Construction 100 F Street, NE Washington, D.

January 24, 2024 CORRESP

January 24, 2024

January 24, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporate Finance Office of Real Estate and Construction 100 F Street, NE Washington, D.

January 5, 2024 EX-99.1

MEDICAL PROPERTIES TRUST PROVIDES UPDATE ON STEWARD HEALTH CARE

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST PROVIDES UPDATE ON STEWARD HEALTH CARE Birmingham, AL – January 4, 2024 – Medical Properties Trust, Inc. (the “Company” or “MPT”) (NYSE: MPW) today announced plans to accelerate its efforts t

January 5, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 2, 2024 MEDICAL PROPERTIE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 2, 2024 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Numb

December 14, 2023 EX-10.1

Form of Award Agreement for Restricted Stock***

EX-10.1 Exhibit 10.1 MEDICAL PROPERTIES TRUST, INC. AMENDED AND RESTATED 2019 EQUITY INCENTIVE PLAN AWARD AGREEMENT FOR RESTRICTED STOCK THIS AWARD AGREEMENT (the “Agreement”) is made effective and entered into with an award grant date as of December , 2023 (the “Grant Date”) by and between MEDICAL PROPERTIES TRUST, INC., a Maryland corporation (the “Company”), and (the “Participant”) pursuant to

December 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 8, 2023 MEDICAL PROPERTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 8, 2023 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of

November 21, 2023 CORRESP

November 21, 2023

November 21, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporate Finance Office of Real Estate and Construction 100 F Street, NE Washington, D.

November 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file n

October 26, 2023 EX-99.2

Medical Properties Trust QUARTERLY SUPPLEMENTAL THIRD QUARTER 2023

EX-99.2 Exhibit 99.2 Medical Properties Trust QUARTERLY SUPPLEMENTAL THIRD QUARTER 2023 THIRD QUARTER 2023 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 6 Debt Summary 7 Debt Maturities and Debt Metrics 8 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 9 Total Assets and Revenues by Asset Type, Operator, State and Country

October 26, 2023 EX-99.1

MEDICAL PROPERTIES TRUST, INC. CONFIRMS LONG-TERM STRENGTH, STABILITY AND PERFORMANCE OF BUSINESS MODEL IN THIRD QUARTER RESULTS Per Share Net Income of $0.19 and Normalized FFO of $0.38 in Third Quarter Expected Liquidity Transactions in the Next Tw

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. CONFIRMS LONG-TERM STRENGTH, STABILITY AND PERFORMANCE OF BUSINESS MODEL IN THIRD QUARTER RESULTS Per Share Net Income of $0.19 and Normalized FFO of $0.38 in Third Quarter Expected Liq

October 26, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 26, 2023 MEDICAL PROPERTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 26, 2023 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of

August 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file number

August 8, 2023 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS Per Share Net Loss of ($0.07) and Normalized FFO of $0.48 in Second Quarter

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS Per Share Net Loss of ($0.07) and Normalized FFO of $0.48 in Second Quarter Birmingham, AL – August 8, 2023 – Medical Properties Trust, Inc. (the “Company

August 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 8, 2023 MEDICAL PROPERTIES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 8, 2023 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of i

August 8, 2023 EX-99.2

MPT Medical Properties Trust QUARTERLY SUPPLEMENTAL SECOND QUARTER 2023

EX-99.2 Exhibit 99.2 MPT Medical Properties Trust QUARTERLY SUPPLEMENTAL SECOND QUARTER 2023 3 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION 6 Reconciliation of Net Income to Funds from Operations 6 Debt Summary 7 Debt Maturities and Debt Metrics 8 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 9 9 Total Assets and Revenues by Asset Type, Operator, State and Country 10 Rent

July 18, 2023 CORRESP

July 18, 2023

July 18, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporate Finance Office of Real Estate and Construction 100 F Street, NE Washington, D.

May 26, 2023 8-K

Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 25, 2023 MEDICAL PROPERTIES TRUST, INC. (Exact name of Registrant as Specified in Its Charter) Maryland 001-32559 20-0191742 (State or Other Jurisdiction of Incorporation) (Commis

May 25, 2023 EX-99.1

MEDICAL PROPERTIES TRUST ANNOUNCES PROSPECT RECAPITALIZATION TRANSACTIONS Third-Party Lenders Invest $375 Million in Prospect Proceeds Fully Repay Prospect’s ABL Facility

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director – Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST ANNOUNCES PROSPECT RECAPITALIZATION TRANSACTIONS Third-Party Lenders Invest $375 Million in Prospect Proceeds Fully Repay Prospect’s ABL Facility Birmingham, AL – May 23, 2023 – Medical Proper

May 25, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 23, 2023 MEDICAL PROPERTIES T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 23, 2023 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Number

May 10, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file numbe

April 27, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, fo

April 27, 2023 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS Per Share Net Income of $0.05 and Normalized FFO of $0.37 in First Quarter Recent Transactions Validate Underwritten Values; Provides Additional Capital Flexibility Declared Second Quarter

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS Per Share Net Income of $0.05 and Normalized FFO of $0.37 in First Quarter Recent Transactions Validate Underwritten Values; Provides Additional Capital Fl

April 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 27, 2023 MEDICAL PROPERTIES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 27, 2023 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of i

April 27, 2023 EX-99.2

QUARTERLY SUPPLEMENTAL FIRST QUARTER 2023

EX-99.2 Exhibit 99.2 QUARTERLY SUPPLEMENTAL FIRST QUARTER 2023 FORWARD-LOOKING STATEMENTS COMPANY OVERVIEW Forward-looking statements involve known and unknown 3 risks, uncertainties and other factors that may cause the actual results of the Company or future events to differ Company Information 3 materially from those expressed in or underlying such forward-looking statements, including without l

April 27, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confid

April 10, 2023 EX-99.1

MEDICAL PROPERTIES TRUST RESPONDS TO WALL STREET JOURNAL ARTICLE

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director – Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST RESPONDS TO WALL STREET JOURNAL ARTICLE Birmingham, AL – April 7, 2023 – Medical Properties Trust, Inc. (the “Company” or “MPT”) (NYSE: MPW) today issued a statement to address content of a Wa

April 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 7, 2023 MEDICAL PROPERTIES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 7, 2023 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of in

March 31, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 30, 2023 MEDICAL PROPERTIES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 30, 2023 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of i

March 31, 2023 EX-99.1

MEDICAL PROPERTIES TRUST FILES LAWSUIT AGAINST SHORT-SELLER VICEROY RESEARCH AND ITS MEMBERS, SENDS LETTER TO SHAREHOLDERS Viceroy’s Numerous Defamatory, False and Misleading Claims Have Caused Serious Harm to MPT and its Investors Shareholder Letter

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director – Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST FILES LAWSUIT AGAINST SHORT-SELLER VICEROY RESEARCH AND ITS MEMBERS, SENDS LETTER TO SHAREHOLDERS Viceroy’s Numerous Defamatory, False and Misleading Claims Have Caused Serious Harm to MPT and

March 24, 2023 CORRESP

March 24, 2023

March 24, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporate Finance Office of Real Estate and Construction 100 F Street, NE Washington, D.

March 1, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file

March 1, 2023 EX-21

Subsidiaries of Medical Properties Trust, Inc.

Exhibit 21.1 SUBSIDIARIES OF REGISTRANT Subsidiaries Jurisdiction of Organization Jurisdiction(s) in Which Qualified as a Foreign Corporation Medical Properties Trust, LLC Delaware Alabama, Massachusetts Mountain View-MPT Hospital, LLC Delaware Idaho MPT of Altoona, LLC Delaware Wisconsin MPT of Alvarado, LLC Delaware California MPT of Alvarado, L.P. Delaware California MPT of Alvin FCER, LLC Dela

February 27, 2023 EX-99.1

Fourth Quarter 2022 Supplemental Update FEBRUARY 2023

EX-99.1 Exhibit 99.1 Fourth Quarter 2022 Supplemental Update FEBRUARY 2023 FORWARD-LOOKING STATEMENTS This presentation includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements can generally be identified by the use of forward-looking words such as

February 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 27, 2023 MEDICAL PROPERT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 27, 2023 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Maryland 001-32559 20-0191742 (State or other jurisdiction of incorporation or orga

February 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 16, 2023 MEDICAL PROPERT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 16, 2023 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction o

February 23, 2023 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FOURTH QUARTER AND FULL-YEAR RESULTS Per Share Net Loss of ($0.24) and Normalized FFO of $0.43 in Fourth Quarter 35% Growth in Net Income and 4% Growth in Both NFFO and AFFO, on a Per Share Basis, in Full-Year 2

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FOURTH QUARTER AND FULL-YEAR RESULTS Per Share Net Loss of ($0.24) and Normalized FFO of $0.43 in Fourth Quarter 35% Growth in Net Income and 4% Growth in Both NFFO and AFFO, on

February 23, 2023 EX-99.2

Q4 2022SUPPLEMENTAL

EX-99.2 Exhibit 99.2 Q4 2022SUPPLEMENTAL COMPANY OVERVIEWCompany Information 3FINANCIAL INFORMATIONReconciliation of Net Income to Funds from Operations 6Debt Summary 7Adjusted Net Debt / Annualized EBITDAre 8PORTFOLIO INFORMATIONAdjusted Lease and Loan Maturity Schedule 9Total Assets and Revenuesby Asset Type, Operator, State and Country 10Rent Coverage 13Summary of Investments and Development Pr

February 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 23, 2023 MEDICAL PROPERT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 23, 2023 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction o

February 23, 2023 EX-99.1

CO-FOUNDER EMMETT E. MCLEAN TO RETIRE AS MEDICAL PROPERTIES TRUST EXECUTIVE VICE PRESIDENT, CHIEF OPERATING OFFICER AND SECRETARY

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] CO-FOUNDER EMMETT E. MCLEAN TO RETIRE AS MEDICAL PROPERTIES TRUST EXECUTIVE VICE PRESIDENT, CHIEF OPERATING OFFICER AND SECRETARY Birmingham, AL – February 23, 2023 – Medical Properties Trust, Inc. (the “Company” or

February 9, 2023 SC 13G/A

MPW / Medical Properties Trust, Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 17)* Name of issuer: Medical Properties Trust Inc. Title of Class of Securities: REIT CUSIP Number: 58463J304 Date of Event Which Requires Filing of this Statement: December 30, 2022 Check the appropriate box to designate the rule pursuant to which this Schedule is filed

February 8, 2023 CORRESP

February 8, 2023

February 8, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporate Finance Office of Real Estate and Construction 100 F Street, NE Washington, D.

November 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file n

November 2, 2022 CORRESP

November 2, 2022

November 2, 2022 VIA EDGAR United States Securities and Exchange Commission Division of Corporate Finance Office of Real Estate and Construction 100 F Street, NE Washington, D.

October 27, 2022 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS THIRD QUARTER RESULTS Per Share Net Income of $0.37 and Normalized FFO of $0.45 in Third Quarter Year-to-Date Capital Recycling Transactions Generate Approximately $1.8 Billion of Cash

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS THIRD QUARTER RESULTS Per Share Net Income of $0.37 and Normalized FFO of $0.45 in Third Quarter Year-to-Date Capital Recycling Transactions Generate Approximately $1.8 Billion of Cash

October 27, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 27, 2022 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of

October 27, 2022 EX-99.2

MEDICAL PROPERTIES TRUST Q3 2022 SUPPLEMENTAL

Exhibit 99.2 MEDICAL PROPERTIES TRUST Q3 2022 SUPPLEMENTAL COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 6 Debt Summary 7 Adjusted Net Debt / Annualized EBITDAre 8 PORTFOLIO INFORMATION Adjusted Lease and Loan Maturity Schedule 9 Total Adjusted Gross Assets and Adjusted Revenues by Asset Type, Operator, State and Country 10 Rent

October 11, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 11, 2022 MEDICAL PROPERTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 11, 2022 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of

October 11, 2022 EX-99.1

MEDICAL PROPERTIES TRUST ANNOUNCES AUTHORIZATION OF STOCK REPURCHASE PROGRAM

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director ? Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST ANNOUNCES AUTHORIZATION OF STOCK REPURCHASE PROGRAM Birmingham, AL ? October 10, 2022 ? Medical Properties Trust, Inc. (the ?Company? or ?MPT?) (NYSE: MPW) today announced that its Board of Directors

September 28, 2022 CORRESP

September 28, 2022

September 28, 2022 VIA EDGAR United States Securities and Exchange Commission Division of Corporate Finance Office of Real Estate and Construction 100 F Street, NE Washington, D.

August 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file number

August 8, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table FORM S-8 (Form Type) MEDICAL PROPERTIES TRUST, INC.

August 8, 2022 S-8

As filed with the Securities and Exchange Commission on August 8, 2022

As filed with the Securities and Exchange Commission on August 8, 2022 File No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 MEDICAL PROPERTIES TRUST, INC. (Exact name of registrant as specified in its charter) Maryland 20-0191742 (State or other jurisdiction of incorporation or organization) (I.R.S. E

August 3, 2022 EX-99.3

Pictured: Morton Hospital Investor Update AUGUST 2022

Exhibit 99.3 Pictured: Morton Hospital Investor Update AUGUST 2022 AT THE VERY HEART OF HEALTH CARE.® FORWARD-LOOKING STATEMENTS This presentation includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements can generally be identified by the use of for

August 3, 2022 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS Per Share Net Income of $0.32 and Normalized FFO of $0.46 in Second Quarter 7% Growth in Per Share NFFO Versus Prior-Year Quarter Expansion of Spain Footprint Includes New Relationship wit

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS Per Share Net Income of $0.32 and Normalized FFO of $0.46 in Second Quarter 7% Growth in Per Share NFFO Versus Prior-Year Quarter Expansion of Spain Footprint Inc

August 3, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 3, 2022 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of i

August 3, 2022 EX-99.2

Medical properties trustQ2 2022 Supplemental

Exhibit 99.2 Medical properties trustQ2 2022 Supplemental 3 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 6 6 Debt Summary 7 Pro Forma Net Debt / Annualized Adjusted EBITDAre 8 PORTFOLIO INFORMATION Pro Forma Lease and Loan Maturity Schedule 9 9 Total Pro Forma Gross Assets and Adjusted Revenue by Asset Type, Operator, State and

July 6, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 29, 2022 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Maryland Delaware 001-32559 333-177186 20-0191742 20-02

July 6, 2022 EX-1.1

Second Amended and Restated Revolving Credit and Term Loan Agreement, dated as of June 29, 2022, among Medical Properties Trust, Inc., MPT Operating Partnership, L.P., the several lenders from time to time party thereto, Bank of America, N.A., as syndication agent, and JPMorgan Chase Bank, N.A., as administrative agent

EX-1.1 2 d379139dex11.htm EX-1.1 Exhibit 1.1 Execution Version SECOND AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT among MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P., as Borrower, The Several Lenders from Time to Time Parties Hereto, JPMORGAN CHASE BANK, N.A., as Administrative Agent BANK OF AMERICA, N.A., as Syndication Agent BARCLAYS BANK PLC, GOLDMAN SACHS BAN

May 27, 2022 8-K

Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 26, 2022 Medical Properties Trust, Inc. (Exact name of Registrant as Specified in Its Charter) Maryland 001-32559 20-0191742 (State or Other Jurisdiction of Incorporation) (Commis

May 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file numbe

April 28, 2022 EX-99.2

2024 AUD Term Loan (A$1.2B) Fixed 2.450% 897,840 7.2% 3.325% Notes Due 2025 (€500M) (A) Fixed 3.325% (A) Fixed (C) 1.949% 2025 GBP Term Loan (£700M) 0.993% Notes Due 2026 (€500M) (A) Fixed 0.993% 5.250% Notes Due 2026 Fixed 5.250%

Exhibit 99.2 Q1 2022 SUPPLEMENTAL FORWARD-LOOKING STATEMENTS COMPANY OVERVIEW Forward-looking statements involve known and 3 unknown risks, uncertainties and other factors that Company Information 3 may cause the actual results of the Company or future events to differ materially from those expressed in or underlying such forward-looking statements, including without limitation: Normalized FFO per

April 28, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confid

April 28, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of

April 28, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 28, 2022 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of i

April 28, 2022 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS Per Share Net Income of $1.05 and Normalized FFO of $0.47 in First Quarter 12% Growth in Per Share NFFO Versus Prior-Year Quarter Acquisitions, Dispositions and Macquarie Partnership Consis

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS Per Share Net Income of $1.05 and Normalized FFO of $0.47 in First Quarter 12% Growth in Per Share NFFO Versus Prior-Year Quarter Acquisitions, Dispositions and Ma

April 28, 2022 EX-99.3

® AT THE VERY HEART OF HEALTHCARE.

Exhibit 99.3 HM Torrelodones ? Madrid, Spain INVESTOR UPDATE APRIL 2022 ? AT THE VERY HEART OF HEALTHCARE. FORWARD-LOOKING STATEMENTS This presentation includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements can generally be identified by the use o

March 18, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 16, 2022 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Numbe

March 18, 2022 EX-99.1

MEDICAL PROPERTIES TRUST COMPLETES HOSPITAL PARTNERSHIP WITH MACQUARIE ASSET MANAGEMENT $1.7 Billion Valuation and 47% Gain on Sale of Real Estate Point to Embedded Value in MPT’s Portfolio $1.3 Billion in Cash Proceeds to MPT to Reduce Debt

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director ? Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST COMPLETES HOSPITAL PARTNERSHIP WITH MACQUARIE ASSET MANAGEMENT $1.7 Billion Valuation and 47% Gain on Sale of Real Estate Point to Embedded Value in MPT?s Portfolio $1.3 Billion in Cash Proceeds to MP

March 1, 2022 EX-21.1

Subsidiaries of Medical Properties Trust, Inc.

EX-21.1 3 mpw-ex2117.htm EX-21.1 Exhibit 21.1 SUBSIDIARIES OF REGISTRANT Subsidiaries Jurisdiction of Organization Jurisdiction(s) in Which Qualified as a Foreign Corporation Medical Properties Trust, LLC Delaware Alabama, Massachusetts Mountain View-MPT Hospital, LLC Delaware Idaho MPT of Allen FCER, LLC Delaware Texas MPT of Altoona, LLC Delaware Wisconsin MPT of Alvarado, LLC Delaware Californi

March 1, 2022 EX-10.30

Amendment No. 2 to Amended and Restated Revolving Credit and Term Loan Agreement, dated as of November 22, 2021, among Medical Properties Trust, Inc., MPT Operating Partnership, L.P., the several lenders from time to time party thereto, and JPMorgan Chase Bank, N.A., as administrative agent

Exhibit 10.30 AMENDMENT NO. 2 TO AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT This AMENDMENT NO. 2 TO AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT, dated as of November 22, 2021 (this ?Amendment No. 2?), is by and among MEDICAL PROPERTIES TRUST, INC., a Maryland corporation (?Holdings?), MPT OPERATING PARTNERSHIP, L.P., a Delaware limited partnership (the ?Borrowe

March 1, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ?ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ?TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file n

February 23, 2022 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 17, 2022 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction o

February 23, 2022 EX-99.1

EMILY W. MURPHY APPOINTED TO THE BOARD OF DIRECTORS OF MEDICAL PROPERTIES TRUST

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] EMILY W. MURPHY APPOINTED TO THE BOARD OF DIRECTORS OF MEDICAL PROPERTIES TRUST Birmingham, AL ? February 23, 2022 ? Medical Properties Trust, Inc. (the ?Company? or ?MPT?) (NYSE: MPW) today announced the appointment of Emil

February 14, 2022 SC 13G/A

MPW / Medical Properties Trust, Inc. / COHEN & STEERS, INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 (Exit Filing)* Medical Properties Trust Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 58463J304 (CUSIP Number) December 31, 2021 (Date of Event Which Req

February 10, 2022 SC 13G/A

MPW / Medical Properties Trust, Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 16)* Name of issuer: Medical Properties Trust Inc. Title of Class of Securities: REIT CUSIP Number: 58463J304 Date of Event Which Requires Filing of this Statement: December 31, 2021 Check the appropriate box to designate the rule pursuant to which this Schedule is filed

February 4, 2022 SC 13G/A

MPW / Medical Properties Trust, Inc. / WELLINGTON MANAGEMENT GROUP LLP - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1 )* Medical Properties Trust, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 58463J304 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to wh

February 3, 2022 EX-99.2

MPT Medical Properties Trust SUPPLEMENTAL Q4

Exhibit 99.2 MPT Medical Properties Trust SUPPLEMENTAL Q4 3 (COMPANY)OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 6 6 Debt Summary 7 Debt Maturity Schedule 8 Pro Forma Net Debt /Annualized Adjusted EBITDA 9 PORTFOLIO INFORMATION Pro Forma Lease and Loan Maturity Schedule 10 10 (Total)Pro Forma Gross Assets and Adjusted Revenue by Asset

February 3, 2022 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FOURTH QUARTER AND FULL-YEAR RESULTS Per Share Net Income of $0.34 and Normalized FFO of $0.47 in Fourth Quarter Robust Double-Digit Growth in Full-Year Net Income, NFFO and AFFO per Share $3.9 Billion of Invest

Exhibit 99.1 Contact: Drew Babin, CFA, CMA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FOURTH QUARTER AND FULL-YEAR RESULTS Per Share Net Income of $0.34 and Normalized FFO of $0.47 in Fourth Quarter Robust Double-Digit Growth in Full-Year Net Income, NFFO and AFFO per Sh

February 3, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 3, 2022 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of

January 3, 2022 EX-25.1

Statement of Eligibility on Form T-1

Exhibit 25.1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 ? Check if an Application to Determine Eligibility of a Trustee Pursuant to Section 305(b)(2) WILMINGTON TRUST, NATIONAL ASSOCIATION (Exact name of trustee as specified in its charter) 16-1486454 (I.R.S. employer identification no.) 1100 North Market Street Wilmington, DE 19890-0001 (Address of principal

January 3, 2022 S-3ASR

As filed with the Securities and Exchange Commission on December 30, 2021

Table of Contents As filed with the Securities and Exchange Commission on December 30, 2021 Registration No.

November 9, 2021 EX-10.2

Amendment to Amended and Restated Revolving Credit and Term Loan Agreement, dated as of September 29, 2021, among Medical Properties Trust, Inc., MPT Operating Partnership, L.P., the several lenders from time to time party thereto, Bank of America, N.A., as syndication agent, and JPMorgan Chase Bank, N.A., as administrative agent

EX-10.2 3 mpw-ex102106.htm EX-10.2 Exhibit 10.2 AMENDMENT NO. 1 TO AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT This AMENDMENT NO. 1 TO AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT, dated as of September 29, 2021 (this “Amendment No. 1”), is by and among MEDICAL PROPERTIES TRUST, INC., a Maryland corporation (“Holdings”), MPT OPERATING PARTNERSHIP, L.P., a Delawar

November 9, 2021 EX-10.1

Amended and Restated Master Lease Agreement between certain subsidiaries of MPT Operating Partnership, L.P. as Lessor and certain subsidiaries of Steward Health Care System LLC, Lessee

EXHIBIT 10.1 AMENDED AND RESTATED MASTER LEASE AGREEMENT BY AND AMONG THE ENTITIES LISTED ON SCHEDULE 1-A ATTACHED HERETO, (collectively, jointly and severally, ?Lessor?) AND THE ENTITIES LISTED ON SCHEDULE 1-B ATTACHED HERETO, (collectively, jointly and severally, as ?Lessee?) August 27, 2021 4834-1440-2281v12 Table of Contents Page ARTICLE I. DEFINITIONS 3 1.1. Certain Defined Terms 3 1.2. Inter

November 9, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file n

October 28, 2021 EX-99.2

Medical Properties Trust SUPPLEMENTAL Q3

Exhibit 99.2 Medical Properties Trust SUPPLEMENTAL Q3 3 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 6 6 Debt Summary 7 Debt Maturity Schedule 8 Pro Forma Net Debt /Annualized Adjusted EBITDA 9 PORTFOLIO INFORMATION Pro Forma Lease and Loan Maturity Schedule 10 10 Total Pro Forma Gross Assets and Adjusted Revenue by Asset Type,

October 28, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 28, 2021 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of

October 28, 2021 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS THIRD QUARTER RESULTS Per Share Net Income of $0.29 and Normalized FFO of $0.44 in Third Quarter Double-Digit Per Share NFFO and AFFO Growth Year-to-Date in 2021 Versus Prior-Year Period Announced Transactions E

EX-99.1 2 d403434dex991.htm EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA Senior Managing Director of Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS THIRD QUARTER RESULTS Per Share Net Income of $0.29 and Normalized FFO of $0.44 in Third Quarter Double-Digit Per Share NFFO and AFFO Growth Year-to-Date

October 13, 2021 EX-4.2

Nineteenth Supplemental Indenture, dated as of October 6, 2021, by and among MPT Operating Partnership, L.P. and MPT Finance Corporation, as issuers, Medical Properties Trust, Inc., as parent and guarantor, Wilmington Trust, National Association, as trustee, and Elavon Financial Services DAC, as initial paying agent, registrar and transfer agent

Exhibit 4.2 Execution Version MPT OPERATING PARTNERSHIP, L.P. and MPT FINANCE CORPORATION, as Issuers, MEDICAL PROPERTIES TRUST, INC., as Parent and a Guarantor WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee and ELAVON FINANCIAL SERVICES DAC, as Paying Agent, Registrar and Transfer Agent 0.993% Senior Notes due 2026 NINETEENTH SUPPLEMENTAL INDENTURE Dated as of October 6, 2021 CROSS-REFERENCE

October 13, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 6, 2021 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Maryland Delaware 001-32559 333-177186 20-0191742 20-

September 28, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 22, 2021 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Maryland Delaware 001-32559 333-177186 20-0191742

September 28, 2021 EX-1.1

Underwriting Agreement, dated September 22, 2021, among the Issuers, the Company and Barclays Bank PLC, Goldman Sachs & Co. LLC, J.P. Morgan Securities plc and Merrill Lynch International, as representatives of the several underwriters named therein

Exhibit 1.1 ?500,000,000 MPT OPERATING PARTNERSHIP, L.P. MPT FINANCE CORPORATION 0.993% Senior Notes due 2026 UNDERWRITING AGREEMENT September 22, 2021 Barclays Bank PLC 5 The North Colonnade Canary Wharf London E14 4BB United Kingdom Goldman Sachs & Co. LLC 200 West Street New York, New York 10282 J.P. Morgan Securities plc 25 Bank Street Canary Wharf London E14 5JP United Kingdom Merrill Lynch I

September 24, 2021 424B2

CALCULATION OF REGISTRATION FEE Title of Each Class of Securities to be Registered Amount to be Registered(1) Maximum Offering Price Per Unit Maximum Aggregate Offering Price(1) Amount of Registration Fee 0.993% Senior Notes due 2026 $584,350,000 100

Table of Contents Filed Pursuant to Rule 424(b)(2) Registration Nos. 333-229103, 333-229103-01 and 333-229103-02 CALCULATION OF REGISTRATION FEE Title of Each Class of Securities to be Registered Amount to be Registered(1) Maximum Offering Price Per Unit Maximum Aggregate Offering Price(1) Amount of Registration Fee 0.993% Senior Notes due 2026 $584,350,000 100.000% $584,350,000 $63,752.59(2) Guar

September 22, 2021 FWP

2

Issuer Free Writing Prospectus filed pursuant to Rule 433 supplementing the Preliminary Prospectus Supplement dated September 22, 2021 Registration Nos.

September 22, 2021 424B5

Subject to Completion, dated September 22, 2021

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration Nos. 333-229103, 333-229103-01 and 333-229103-02 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to the securities has become effective under the Securities Act of 1933, as amended. This preliminary prospectus supplement and the accompanying prospectus do

September 1, 2021 EX-99.1

MEDICAL PROPERTIES TRUST AND MACQUARIE INFRASTRUCTURE PARTNERS V ENTER PARTNERSHIP FOR EIGHT MASSACHUSETTS HOSPITALS VALUED AT $1.78 BILLION Expected Cash Proceeds to MPT of $1.3 Billion to Repay Debt and Fund Previously Announced Investments in Inpa

Exhibit 99.1 Contact: Drew Babin, CFA Senior Managing Director ? Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST AND MACQUARIE INFRASTRUCTURE PARTNERS V ENTER PARTNERSHIP FOR EIGHT MASSACHUSETTS HOSPITALS VALUED AT $1.78 BILLION Expected Cash Proceeds to MPT of $1.3 Billion to Repay Debt and Fund Previously Announced

September 1, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 1, 2021 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Commission File Nu

August 9, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file number

July 29, 2021 EX-99.2

Medical Properties Trust Q2 SUPPLEMENTAL 2021

Exhibit 99.2 Medical Properties Trust Q2 SUPPLEMENTAL 2021 3 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 6 6 Debt Summary 7 Debt Maturity Schedule 8 Pro Forma Net Debt /Annualized Adjusted EBITDA 9 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 10 10 Total Pro Forma Gross Assets and Adjusted Revenue by Asset Type, Opera

July 29, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 29, 2021 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of in

July 29, 2021 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS Per Share Net Income of $0.19 and Normalized FFO of $0.43 in Second Quarter Per Share NFFO and AFFO Growth Exceeding 13% Compared to Prior-Year Quarter Year-to-Date Investments of More tha

Exhibit 99.1 Contact: Drew Babin, CFA Senior Managing Director ? Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS Per Share Net Income of $0.19 and Normalized FFO of $0.43 in Second Quarter Per Share NFFO and AFFO Growth Exceeding 13% Compared to Prior-Year Quarter Year-to-Date Inv

June 9, 2021 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1) (Mark One) ?ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 or ?TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-325

June 9, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 9, 2021 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Maryland 001-32559 20-0191742 (State or other jurisdiction of incorporation or organizat

June 9, 2021 EX-99.1

Consolidated Financial Statements of Steward Health Care System LLC as of December 31, 2020 and 2019

Exhibit 99.1 Steward Health Care System LLC Consolidated Financial Statements Years Ended December 31, 2020 and 2019 (With Independent Auditors? Report Thereon) Steward Health Care System LLC Consolidated Financial Statements Years ended December 31, 2020 and 2019 Contents Page Independent Auditors? Report 1 Consolidated Balance Sheets 5 Consolidated Statements of Operations 6 Consolidated Stateme

June 9, 2021 EX-99.1

® AT THE VERY HEART OF HEALTHCARE.® AT THE VERY HEART OF HEALTHCARE.

Exhibit 99.1 Reading Hospital near London, UK REITweek: 2021 Investor Conference JUNE 2021Exhibit 99.1 Reading Hospital near London, UK REITweek: 2021 Investor Conference JUNE 2021 ? AT THE VERY HEART OF HEALTHCARE.? AT THE VERY HEART OF HEALTHCARE. FORWARD-LOOKING STATEMENTS This presentation includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as a

May 28, 2021 8-K

Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 26, 2021 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Maryland 001-32559 20-0191742 (State or other jurisdiction of incorporation or organizat

May 10, 2021 EX-10.1

Amended and Restated Revolving Credit and Term Loan Agreement, dated as of January 15, 2021, among Medical Properties Trust, Inc., MPT Operating Partnership, L.P., the several lenders from time to time party thereto, Bank of America, N.A., as syndication agent, and JPMorgan Chase Bank, N.A., as administrative agent

Execution Version Exhibit 10.1 AMENDED AND RESTATED REVOLVING CREDIT AND TERM LOAN AGREEMENT among MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P., as Borrower, The Several Lenders from Time to Time Parties Hereto, JPMORGAN CHASE BANK, N.A., as Administrative Agent BANK OF AMERICA, N.A., as Syndication Agent BARCLAYS BANK PLC, GOLDMAN SACHS BANK USA, KEYBANK NATIONAL ASSOCIATION, CI

May 10, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file numbe

April 29, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 29, 2021 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of i

April 29, 2021 EX-99.2

Q SUPPLEMENTAL 1 2021

Exhibit 99.2 Q SUPPLEMENTAL 1 2021 3 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 6 6 Debt Summary 7 Debt Maturity Schedule 8 Pro Forma Net Debt /Annualized Adjusted EBITDA 9 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 10 10 Total Pro Forma Gross Assets and Adjusted Revenue by Asset Type, Operator, State and Country 1

April 29, 2021 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS Per Share Net Income of $0.28 and Normalized FFO of $0.42 in First Quarter Per Share NFFO Growth Exceeding 13% Compared to Prior-Year Quarter Year-to-Date Investments of Approximately $1.6

Exhibit 99.1 Contact: Drew Babin, CFA Senior Managing Director ? Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS Per Share Net Income of $0.28 and Normalized FFO of $0.42 in First Quarter Per Share NFFO Growth Exceeding 13% Compared to Prior-Year Quarter Year-to-Date Investments of

April 26, 2021 DEFA14A

- DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (RULE 14A-101) PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definit

April 26, 2021 DEF 14A

Schedule 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (RULE 14A-101) PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definit

March 29, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 24, 2021 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Maryland Delaware 001-32559 333-177186 20-0191742 20-0

March 29, 2021 EX-4.2

Seventeenth Supplemental Indenture, dated as of March 24, 2021, by and among MPT Operating Partnership, L.P. and MPT Finance Corporation, as issuers, Medical Properties Trust, Inc., as parent and guarantor, Wilmington Trust, National Association, as trustee, and Elavon Financial Services DAC, as initial paying agent, registrar and transfer agent

Exhibit 4.2 Execution Version MPT OPERATING PARTNERSHIP, L.P. and MPT FINANCE CORPORATION, as Issuers, MEDICAL PROPERTIES TRUST, INC., as Parent and a Guarantor WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee and ELAVON FINANCIAL SERVICES DAC, as Paying Agent, Registrar and Transfer agent 2.500% Senior Notes due 2026 SEVENTEENTH SUPPLEMENTAL INDENTURE Dated as of March 24, 2021 CROSS-REFERENCE

March 29, 2021 EX-4.4

Eighteenth Supplemental Indenture, dated as of March 24, 2021, by and among MPT Operating Partnership, L.P. and MPT Finance Corporation, as issuers, Medical Properties Trust, Inc., as parent and guarantor, Wilmington Trust, National Association, as trustee, and Elavon Financial Services DAC, as initial paying agent, registrar and transfer agent

Exhibit 4.4 Execution Version MPT OPERATING PARTNERSHIP, L.P. and MPT FINANCE CORPORATION, as Issuers, MEDICAL PROPERTIES TRUST, INC., as Parent and a Guarantor WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee and ELAVON FINANCIAL SERVICES DAC, as Paying Agent, Registrar and Transfer agent 3.375% Senior Notes due 2030 EIGHTEENTH SUPPLEMENTAL INDENTURE Dated as of March 24, 2021 CROSS-REFERENCE T

March 22, 2021 EX-1.1

Underwriting Agreement, dated March 17, 2021, among the Issuers, the Company and Goldman Sachs & Co. LLC, Barclays Bank PLC, J.P. Morgan Securities plc and Merrill Lynch International, as representatives of the several underwriters named therein

Exhibit 1.1 UNDERWRITING AGREEMENT MPT OPERATING PARTNERSHIP, L.P. MPT FINANCE CORPORATION ?500 million 2.500% Senior Notes due 2026 ?350 million 3.375% Senior Notes due 2030 March 17, 2021 Goldman Sachs & Co. LLC 200 West Street New York, New York 10282 Barclays Bank PLC 5 The North Colonnade Canary Wharf London E14 4BB United Kingdom J.P. Morgan Securities plc 25 Bank Street Canary Wharf London

March 22, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 17, 2021 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Maryland Delaware 001-32559 333-177186 20-0191742 20-0

March 19, 2021 424B2

CALCULATION OF REGISTRATION FEE Title of Each Class of Securities to be Registered Amount to be Registered(1) Maximum Offering Price Per Unit Maximum Aggregate Offering Price(1) Amount of Registration Fee 2.500% Senior Notes due 2026 $698,300,000 99.

Table of Contents Filed Pursuant to Rule 424(b)(2) Registration Nos. 333-229103, 333-229103-01 and 333-229103-02 CALCULATION OF REGISTRATION FEE Title of Each Class of Securities to be Registered Amount to be Registered(1) Maximum Offering Price Per Unit Maximum Aggregate Offering Price(1) Amount of Registration Fee 2.500% Senior Notes due 2026 $698,300,000 99.937% $697,860,071.00 $76,136.54(2) 3.

March 17, 2021 FWP

2.500% Senior Notes due 2026 Aggregate Principal Amount: £500,000,000 Title of Securities: 2.500% Senior Notes due 2026 (the “2026 Notes”) Final Maturity Date: March 24, 2026 Public Offering Price: 99.937% Coupon: 2.500% Yield to Maturity: 2.514% Spr

Issuer Free Writing Prospectus filed pursuant to Rule 433 supplementing the Preliminary Prospectus Supplement dated March 17, 2021 Registration Nos.

March 17, 2021 424B5

Subject to Completion, dated March 17, 2021

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration Nos. 333-229103, 333-229103-01 and 333-229103-02 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to the securities has become effective under the Securities Act of 1933, as amended. This preliminary prospectus supplement and the accompanying prospectus do

March 1, 2021 EX-21.1

Subsidiaries of Medical Properties Trust, Inc.

Exhibit 21.1 SUBSIDIARIES OF REGISTRANT Subsidiaries Jurisdiction of Organization Jurisdiction(s) in Which Qualified as a Foreign Corporation Medical Properties Trust, LLC Delaware Alabama, Massachusetts Mountain View-MPT Hospital, LLC Delaware Idaho MPT of Allen FCER, LLC Delaware Texas MPT of Altoona, LLC Delaware Wisconsin MPT of Alvarado, LLC Delaware California MPT of Alvarado, L.P. Delaware

March 1, 2021 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ?ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 or ?TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file n

February 10, 2021 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 15)*

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 15)* Name of issuer: Medical Properties Trust Inc. Title of Class of Securities: REIT CUSIP Number: 58463J304 Date of Event Which Requires Filing of this Statement: December 31, 2020 Check the appropriate box to designate the rule pursuant to which this Schedule is filed

February 4, 2021 SC 13G

SCHEDULE 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Medical Properties Trust, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 58463J304 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to whic

February 4, 2021 EX-99.2

4 Q Supplemental 2020

EX-99.2 Exhibit 99.2 4 Q Supplemental 2020 3 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 6 6 Debt Summary 7 Debt Maturity Schedule 8 Pro Forma Net Debt /Annualized Adjusted EBITDA 9 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 10 10 Total Pro Forma Gross Assets and Adjusted Revenue by Asset Type, Operator, State and C

February 4, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 4, 2021 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of

February 4, 2021 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FOURTH QUARTER AND FULL-YEAR RESULTS Per Share Net Income of $0.20 and Normalized FFO of $0.41 in Fourth Quarter Full-Year Growth in NFFO per Share of Approximately 21% Nearly $3.6 Billion of Investments Closed

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA Senior Managing Director – Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FOURTH QUARTER AND FULL-YEAR RESULTS Per Share Net Income of $0.20 and Normalized FFO of $0.41 in Fourth Quarter Full-Year Growth in NFFO per Share of Approximately 21% Nearly $3.6 Bi

January 22, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 15, 2021 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Maryland Delaware 001-32559 333-177186 20-0191742 20

January 11, 2021 EX-1.1

Underwriting Agreement, dated January 6, 2021, among the Company and MPT Operating Partnership, L.P. and Goldman Sachs & Co. LLC, BofA Securities, Inc., and J.P. Morgan Securities LLC, as representatives of the several underwriters named therein

EX-1.1 Exhibit 1.1 UNDERWRITING AGREEMENT MEDICAL PROPERTIES TRUST, INC. 32,000,000 shares of common stock, par value $0.001 per share January 6, 2021 Goldman Sachs & Co. LLC 200 West Street New York, New York 10282 BofA Securities, Inc. One Bryant Park New York, New York 10036 J.P. Morgan Securities LLC 383 Madison Avenue New York, New York 10179 As Representatives of the several Underwriters lis

January 11, 2021 8-K

Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 6, 2021 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in its Charter) Maryland 001-32559 20-0191742 (State or other jurisdiction of incorporation) (Com

January 8, 2021 424B2

CALCULATION OF REGISTRATION FEE Title of Each Class of Securities to be Registered Amount to be Registered Proposed Maximum Offering Price per Share Proposed Maximum Aggregate Offering Price Amount of Registration Fee(1) Common Stock, par value $0.00

424B2 Table of Contents Filed Pursuant to Rule 424(b)(2) Registration No. 333-229103 CALCULATION OF REGISTRATION FEE Title of Each Class of Securities to be Registered Amount to be Registered Proposed Maximum Offering Price per Share Proposed Maximum Aggregate Offering Price Amount of Registration Fee(1) Common Stock, par value $0.001 per share 36,800,000 $20.05 $737,840,000 $80,498.34 (1) The fil

January 7, 2021 EX-99.1

MEDICAL PROPERTIES TRUST TO ACQUIRE £800 MILLION IN BEHAVIORAL HOSPITALS MPT to Own Critical Real Estate of Europe’s New Dominant Comprehensive Rehabilitation Provider Solidifies MPT’s Leading Position in UK Healthcare Real Estate Market

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA Senior Managing Director – Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST TO ACQUIRE £800 MILLION IN BEHAVIORAL HOSPITALS MPT to Own Critical Real Estate of Europe’s New Dominant Comprehensive Rehabilitation Provider Solidifies MPT’s Leading Position in UK Healthcare Rea

January 7, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 6, 2021 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in its Charter) Maryland 001-32559 20-0191742 Delaware 333-177186

January 6, 2021 424B5

Subject to Completion, dated January 6, 2021

Form 424(b)(5) Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No.

December 7, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 4, 2020 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Maryland Delaware 001-32559 333-177186 20-0191742 20

December 7, 2020 EX-4.2

Sixteenth Supplemental Indenture, dated as of December 4, 2020, by and among MPT Operating Partnership, L.P. and MPT Finance Corporation, as issuers, Medical Properties Trust, Inc. as parent and guarantor, and Wilmington Trust, National Association, as trustee.

EX-4.2 Exhibit 4.2 Execution Version MPT OPERATING PARTNERSHIP, L.P. and MPT FINANCE CORPORATION, as Issuers, MEDICAL PROPERTIES TRUST, INC., as Parent and a Guarantor, and WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee 3.500% Senior Notes due 2031 SIXTEENTH SUPPLEMENTAL INDENTURE Dated as of December 4, 2020 CROSS-REFERENCE TABLE* Trust Indenture Act Section Indenture Section 310(a)(1) 8.10 (

November 24, 2020 8-K

Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 19, 2020 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Maryland Delaware 001-32559 333-177186 20-0191742 2

November 24, 2020 EX-1.1

Underwriting Agreement, dated November 19, 2020, among the Issuers, the Company, Goldman Sachs & Co. LLC, Credit Agricole Securities (USA) Inc. and Wells Fargo Securities, LLC, as representatives of the several underwriters named therein

EX-1.1 Exhibit 1.1 UNDERWRITING AGREEMENT $1,300,000,000 MPT OPERATING PARTNERSHIP, L.P. MPT FINANCE CORPORATION 3.500% Senior Notes due 2031 November 19, 2020 Goldman Sachs & Co. LLC 200 West Street New York, New York 10282 Credit Agricole Securities (USA) Inc. 1301 Avenue of the Americas, 13th Floor New York, New York 10019 Wells Fargo Securities, LLC 550 South Tryon Street, 5th Floor Charlotte,

November 23, 2020 424B2

CALCULATION OF REGISTRATION FEE Title of Each Class of Securities to be Registered Amount to be Registered Proposed Maximum Offering Price Per Unit Proposed Maximum Aggregate Offering Price Amount of Registration Fee 3.500% Senior Notes due 2031 $1,3

424B2 Table of Contents Filed Pursuant to Rule 424(b)(2) Registration Nos. 333-229103, 333-229103-01 and 333-229103-02 CALCULATION OF REGISTRATION FEE Title of Each Class of Securities to be Registered Amount to be Registered Proposed Maximum Offering Price Per Unit Proposed Maximum Aggregate Offering Price Amount of Registration Fee 3.500% Senior Notes due 2031 $1,300,000,000 100% $1,300,000,000

November 20, 2020 FWP

3.500% Senior Notes due 2031

FWP Issuer Free Writing Prospectus filed pursuant to Rule 433 supplementing the Preliminary Prospectus Supplement dated November 19, 2020 Registration Nos.

November 19, 2020 424B5

Subject to Completion, dated November 19, 2020

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration Nos. 333-229103, 333-229103-01 and 333-229103-02 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to the securities has become effective under the Securities Act of 1933, as amended. This preliminary prospectus supplement and the accompanying prospect

November 9, 2020 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file n

October 29, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 29, 2020 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of

October 29, 2020 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS THIRD QUARTER RESULTS Per Share Net Income of $0.25 and Normalized FFO of $0.41 Approximately 25% Year-over-Year Growth in Net Income and NFFO per Share Nearly $2.9 Billion of Investments Closed Year-to-Date

EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA Senior Managing Director – Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS THIRD QUARTER RESULTS Per Share Net Income of $0.25 and Normalized FFO of $0.41 Approximately 25% Year-over-Year Growth in Net Income and NFFO per Share Nearly $2.9 Billion of Investm

October 29, 2020 EX-99.2

Medical Properties Trust

EX-99.2 Exhibit 99.2 Medical Properties Trust 3 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 6 6 Debt Summary 7 Debt Maturity Schedule 8 Pro Forma Net Debt /Annualized Adjusted EBITDA 9 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 10 10 Total Pro Forma Gross Assets and Actual Revenue by Asset Type, Operator, State and

August 18, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 18, 2020 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Maryland 001-32559 20-0191742 (State or other jurisdiction of incorporation or organi

August 18, 2020 EX-99.1

® AT THE VERY HEART OF HEALTHCARE® AT THE VERY HEART OF HEALTHCARE

EX-99.1 Exhibit 99.1 MIZUHO NON-DEAL ROADSHOW AUGUST 2020Exhibit 99.1 MIZUHO NON-DEAL ROADSHOW AUGUST 2020 ® AT THE VERY HEART OF HEALTHCARE® AT THE VERY HEART OF HEALTHCARE FORWARD-LOOKING STATEMENTS This presentation includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended.

August 10, 2020 EX-10.1

Form of Lease Agreement between certain subsidiaries of MPT Operating Partnership, L.P., as Lessor, and Circle Health Ltd. and certain of its subsidiaries, as Lessee

Exhibit10.1 Lease [Name of MPT entity] and BMI Healthcare Limited and Circle Health Holdings Limited of land and buildings at [Property details] NOTE: This document is a conformed copy produced for information purposes only. The original lease dated 31 July 2006 and the deeds of variation to the lease dated 14 December 2018 or 3 June 2019 (as applicable) and 16 June 2020 should be referred to for

August 10, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file number

July 30, 2020 EX-99.2

Supplemental Information SECOND QUARTER 2020

EX-99.2 Exhibit 99.2 Supplemental Information SECOND QUARTER 2020 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 5 Debt Summary 6 Debt Maturity Schedule 7 Pro Forma Net Debt /Annualized Adjusted EBITDA 8 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 9 Total Pro Forma Gross Assets and Actual Revenue by Asset Type, Operator

July 30, 2020 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS Per Share Net Income of $0.21 and Normalized FFO of $0.38 $3.1 Billion of Closed and Announced Investments Year-to-Date 100% of Rent and Interest Collected or Subject to Definitive Repayme

EX-99.1 2 d41231dex991.htm EX-99.1 Exhibit 99.1 Contact: Drew Babin, CFA Senior Managing Director – Corporate Communications Medical Properties Trust, Inc. (646) 884-9809 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS SECOND QUARTER RESULTS Per Share Net Income of $0.21 and Normalized FFO of $0.38 $3.1 Billion of Closed and Announced Investments Year-to-Date 100% of Rent

July 30, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 30, 2020 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of in

May 22, 2020 EX-3.1

Amendment to Second Amended and Restated Bylaws of Medical Properties Trust, Inc.

EX-3.1 Exhibit 3.1 AMENDMENT TO THE SECOND AMENDED AND RESTATED BYLAWS OF MEDICAL PROPERTIES TRUST, INC. Article III, Section 3.01 of the Second Amended and Restated Bylaws of Medical Properties Trust, Inc. (the “Bylaws”) is hereby amended as follows: “SECTION 3.01. Enumeration. The officers of the Corporation shall consist of a President, a Chief Executive Officer, a Secretary and a Treasurer and

May 22, 2020 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 21, 2020 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Maryland 001-32559 20-0191742 (State or other jurisdiction of incorporation or organizat

May 11, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Commission file numbe

April 30, 2020 EX-99.2

Medical Properties Trust Supplemental Information FIRST QUARTER 2020

EX-99.2 Exhibit 99.2 Medical Properties Trust Supplemental Information FIRST QUARTER 2020 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION Reconciliation of Net Income to Funds from Operations 5 Debt Summary 6 Debt Maturity Schedule 7 Pro Forma Net Debt /Annualized Adjusted EBITDA 8 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 9 Total Pro Forma Gross Assets and Actual Revenue

April 30, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 29, 2020 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction of i

April 30, 2020 EX-99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS First Quarter Per Share Net Income of $0.15 and Normalized FFO of $0.37 Completes $2.0 Billion Circle/BMI Acquisition Marking the Largest Transaction in Company’s History; $1.8 Billion in L

EX-99.1 Exhibit 99.1 Contact: Tim Berryman Director – Investor Relations Medical Properties Trust, Inc. (205) 969-3755 [email protected] MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS First Quarter Per Share Net Income of $0.15 and Normalized FFO of $0.37 Completes $2.0 Billion Circle/BMI Acquisition Marking the Largest Transaction in Company’s History; $1.8 Billio

April 24, 2020 DEFA14A

- DEFA14A

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (RULE 14A-101) PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐

April 24, 2020 DEF 14A

Definitive Proxy Statement

DEF 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (RULE 14A-101) PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒

April 8, 2020 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 8, 2020 MEDICAL PROPERTIES TRUST, INC. MPT OPERATING PARTNERSHIP, L.P. (Exact Name of Registrant as Specified in Charter) Maryland Delaware 001-32559 333-177186 20-0191742 20-02

March 23, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 23, 2020 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Maryland 001-32559 20-0191742 (State or other jurisdiction of incorporation or organiz

March 23, 2020 EX-99.1

STATEMENT FROM OUR CEO ON THE COVID-19 PANDEMIC

EX-99.1 Exhibit 99.1 STATEMENT FROM OUR CEO ON THE COVID-19 PANDEMIC The world has been hit with an unprecedented situation with the coronavirus (COVID-19) pandemic. Hospitals around the world are stepping up to the challenge and seeking to meet the urgent healthcare needs created by this pandemic. Medical Properties Trust owns hospitals in some of the hardest hit countries in Europe and, of cours

February 27, 2020 EX-21.1

Subsidiaries of Medical Properties Trust, Inc.

Exhibit 21.1 SUBSIDIARIES OF REGISTRANT Subsidiaries Jurisdiction of Organization Jurisdiction(s) in Which Qualified as a Foreign Corporation Medical Properties Trust, LLC Delaware Alabama, Massachusetts Mountain View-MPT Hospital, LLC Delaware Idaho MPT of Allen FCER, LLC Delaware Texas MPT of Altoona, LLC Delaware Wisconsin MPT of Alvarado, LLC Delaware California MPT of Alvarado, L.P. Delaware

February 27, 2020 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2019 or ☐TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-32559 Medical Propertie

February 27, 2020 EX-4.2

Description of Securities of Medical Properties Trust, Inc. Registered under Section 12 of the Securities Exchange Act, as amended

Exhibit 4.2 Description of Securities of Medical Properties Trust, Inc. Registered under Section 12 of the Securities Exchange Act of 1934, as Amended The following is a summary of the material terms of the shares of common stock, par value $0.001 per share (“Common Stock”), of Medical Properties Trust, Inc., a Maryland corporation (the “Company”), as well as certain relevant provisions of the sec

February 27, 2020 EX-99.1

Consolidated Financial Statements of Steward Health Care System LLC as of and for the years ended December 31, 2018 and 2017.

Exhibit 99.1 Steward CONSOLIDATED FINANCIAL STATEMENTS Steward Health Care System LLC Years Ended December 31, 2018 and 2017 With Report of Independent Auditors Steward Health Care System LLC Consolidated Financial Statements Years Ended December 31, 2018 and 2017 Contents Report of Independent Auditors 1 Consolidated Balance Sheets 3 Consolidated Statements of Operations 4 Consolidated Statements

February 21, 2020 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 14, 2020 MEDICAL PROPERTIES TRUST, INC. (Exact Name of Registrant as Specified in Charter) Commission File Number 001-32559 Maryland 20-0191742 (State or other jurisdiction o

February 21, 2020 EX-99.1

CATERINA A. MOZINGO ELECTED TO THE BOARD OF DIRECTORS OF MEDICAL PROPERTIES TRUST

EX-99.1 Exhibit 99.1 Contact: Tim Berryman Director – Investor Relations Medical Properties Trust, Inc. (205) 969-3755 [email protected] CATERINA A. MOZINGO ELECTED TO THE BOARD OF DIRECTORS OF MEDICAL PROPERTIES TRUST Birmingham, AL – February 18, 2020 – Medical Properties Trust, Inc. (the “Company” or “MPT”) (NYSE: MPW) has announced the election of Caterina Ardon Mozingo, CPA

February 14, 2020 SC 13G/A

58463J304 / Medical Properties Trust Inc / MASSACHUSETTS FINANCIAL SERVICES CO /MA/ - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3 )* MEDICAL PROPERTIES TRUST, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 58463J304 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to wh

February 11, 2020 SC 13G/A

MPW / Medical Properties Trust Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 14)* Name of issuer: Medical Properties Trust Inc Title of Class of Securities: REIT CUSIP Number: 58463J304 Date of Event Which Requires Filing of this Statement: December 31, 2019 Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

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