Basic Stats
| Insider Profile | venBio Select Advisor LLC |
| Portfolio Value | $ 5,710,277,507 |
| Current Positions | 30 |
Latest Holdings, Performance, AUM (from 13F, 13D)
Avoro Capital Advisors LLC has disclosed 30 total holdings in their latest SEC filings. Most recent portfolio value is calculated to be $ 5,710,277,507 USD. Actual Assets Under Management (AUM) is this value plus cash (which is not disclosed). Avoro Capital Advisors LLC’s top holdings are Ascendis Pharma A/S - Depositary Receipt (Common Stock) (US:ASND) , United Therapeutics Corporation (US:UTHR) , argenx SE - Depositary Receipt (Common Stock) (US:ARGX) , Madrigal Pharmaceuticals, Inc. (US:MDGL) , and Krystal Biotech, Inc. (US:KRYS) . Avoro Capital Advisors LLC’s top industries are "Measuring, Analyzing, And Controlling Instruments; Photographic, Medical And Optical Goods; Watches And Clocks" (sic 38) , "Health Services" (sic 80) , and "Engineering, Accounting, Research, Management, And Related Services" (sic 87) .
Top Increases This Quarter
We use the change in the portfolio allocation because this is the most meaningful metric. Changes can be due to trades or changes in share prices.
| Security | Shares (MM) |
Value (MM$) |
Portfolio % | ΔPortfolio % |
|---|---|---|---|---|
| 3.50 | 186.76 | 3.2706 | 3.2706 | |
| 4.98 | 859.55 | 15.0526 | 2.3582 | |
| 6.56 | 286.08 | 5.0100 | 2.2502 | |
| 4.15 | 195.88 | 3.4303 | 1.7410 | |
| 3.16 | 165.98 | 2.9067 | 0.9358 | |
| 10.60 | 167.48 | 2.9330 | 0.7234 | |
| 3.62 | 50.53 | 0.8849 | 0.5251 | |
| 6.30 | 148.43 | 2.5993 | 0.4615 | |
| 21.70 | 50.13 | 0.8778 | 0.4439 | |
| 6.75 | 66.28 | 1.1608 | 0.4402 |
Top Decreases This Quarter
We use the change in the portfolio allocation because this is the most meaningful metric. Changes can be due to trades or changes in share prices.
| Security | Shares (MM) |
Value (MM$) |
Portfolio % | ΔPortfolio % |
|---|---|---|---|---|
| 0.38 | 48.07 | 0.8418 | -4.4772 | |
| 2.66 | 365.64 | 6.4033 | -1.2826 | |
| 2.37 | 681.02 | 11.9262 | -0.9453 | |
| 18.00 | 103.14 | 1.8062 | -0.8049 | |
| 1.88 | 567.45 | 9.9373 | -0.5179 | |
| 12.22 | 211.57 | 3.7050 | -0.4673 | |
| 4.50 | 40.32 | 0.7061 | -0.3124 | |
| 5.85 | 21.88 | 0.3832 | -0.3038 | |
| 0.33 | 12.00 | 0.2101 | -0.2590 | |
| 1.18 | 647.68 | 11.3424 | -0.0687 |
13D/G Filings
This is a list of 13D and 13G filings made in the last year (if any). Click the link icon to see the full transaction history. Green rows indicate new positions. Red rows indicate closed positions.
| File Date | Form | Security | Prev Shares |
Current Shares |
ΔShares % | % Ownership |
% ΔOwnership | |
|---|---|---|---|---|---|---|---|---|
| 2025-08-14 | QURE / uniQure N.V. | 3,625,000 | 6.60 | |||||
| 2025-08-14 | SLNO / Soleno Therapeutics, Inc. | 2,181,000 | 2,050,000 | -6.01 | 4.10 | -26.79 | ||
| 2025-08-14 | BPMC / Blueprint Medicines Corporation | 3,850,000 | 375,000 | -90.26 | 0.60 | -90.00 | ||
| 2025-08-14 | GLUE / Monte Rosa Therapeutics, Inc. | 4,345,000 | 3,725,000 | -14.27 | 6.10 | -14.08 | ||
| 2025-08-14 | ARWR / Arrowhead Pharmaceuticals, Inc. | 12,028,552 | 11,517,441 | -4.25 | 8.30 | -13.54 | ||
| 2025-08-14 | TRML / Tourmaline Bio, Inc. | 2,222,222 | 2,555,555 | 15.00 | 9.95 | 14.37 | ||
| 2025-08-14 | MLTX / MoonLake Immunotherapeutics | 4,150,000 | 6.50 | |||||
| 2025-05-15 | FOLD / Amicus Therapeutics, Inc. | 23,175,000 | 20,500,000 | -11.54 | 6.70 | -14.10 | ||
| 2025-05-15 | BCRX / BioCryst Pharmaceuticals, Inc. | 13,050,000 | 8,700,000 | -33.33 | 4.20 | -34.38 | ||
| 2025-03-04 | WHWK / Whitehawk Therapeutics, Inc. | 3,581,961 | 11,914,961 | 232.64 | 19.99 | 37.86 | ||
| 2025-02-14 | VERA / Vera Therapeutics, Inc. | 4,309,590 | 5,610,000 | 30.17 | 8.90 | 12.66 | ||
| 2024-11-14 | VRCA / Verrica Pharmaceuticals Inc. | 6,583,332 | 0 | -100.00 | 0.00 | -100.00 | ||
| 2024-11-14 | SYRE / Spyre Therapeutics, Inc. | 1,839,138 | 885,059 | -51.88 | 1.70 | -66.67 | ||
| 2024-11-14 | MRNS / Marinus Pharmaceuticals, Inc. | 3,150,000 | 0 | -100.00 | 0.00 | -100.00 | ||
| 2024-11-14 | GPCR / Structure Therapeutics Inc. - Depositary Receipt (Common Stock) | 6,999,999 | 0 | -100.00 | 0.00 | -100.00 | ||
| 2024-11-14 | ASND / Ascendis Pharma A/S - Depositary Receipt (Common Stock) | 3,755,555 | 4,988,888 | 32.84 | 8.20 | 26.15 | ||
| 2024-11-14 | KYMR / Kymera Therapeutics, Inc. | 3,775,000 | 7,750,000 | 105.30 | 9.99 | 46.91 | ||
| 2024-11-14 | TSHA / Taysha Gene Therapies, Inc. | 23,094,444 | 9.99 | |||||
| 2024-11-14 | RNA / Avidity Biosciences, Inc. | 9,935,792 | 8.30 | |||||
| 2024-11-14 | OCUL / Ocular Therapeutix, Inc. | 12,714,874 | 7.90 |
13F and Fund Filings
This form was filed on 2025-08-14 for the reporting period 2025-06-30. Click the link icon to see the full transaction history.
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| Security | Type | Avg Share Price | Shares (MM) |
ΔShares (%) |
ΔShares (%) |
Value ($MM) |
Portfolio (%) |
ΔPortfolio (%) |
|
|---|---|---|---|---|---|---|---|---|---|
| ASND / Ascendis Pharma A/S - Depositary Receipt (Common Stock) | 4.98 | -4.56 | 859.55 | 5.69 | 15.0526 | 2.3582 | |||
| UTHR / United Therapeutics Corporation | 2.37 | -11.40 | 681.02 | -17.41 | 11.9262 | -0.9453 | |||
| ARGX / argenx SE - Depositary Receipt (Common Stock) | 1.18 | -4.87 | 647.68 | -11.40 | 11.3424 | -0.0687 | |||
| MDGL / Madrigal Pharmaceuticals, Inc. | 1.88 | -7.28 | 567.45 | -15.28 | 9.9373 | -0.5179 | |||
| KRYS / Krystal Biotech, Inc. | 2.66 | -2.60 | 365.64 | -25.74 | 6.4033 | -1.2826 | |||
| KYMR / Kymera Therapeutics, Inc. | 6.56 | 1.48 | 286.08 | 61.80 | 5.0100 | 2.2502 | |||
| APLS / Apellis Pharmaceuticals, Inc. | 12.22 | 0.00 | 211.57 | -20.85 | 3.7050 | -0.4673 | |||
| RNA / Avidity Biosciences, Inc. | 7.05 | -7.54 | 200.22 | -11.05 | 3.5063 | -0.0071 | |||
| MLTX / MoonLake Immunotherapeutics | 4.15 | 49.81 | 195.88 | 80.99 | 3.4303 | 1.7410 | |||
| AKRO / Akero Therapeutics, Inc. | 3.50 | 186.76 | 3.2706 | 3.2706 | |||||
| SLNO / Soleno Therapeutics, Inc. | 2.05 | -18.81 | 171.75 | -4.80 | 3.0077 | 0.1917 | |||
| XENE / Xenon Pharmaceuticals Inc. | 5.40 | -5.95 | 169.02 | -12.26 | 2.9599 | -0.0469 | |||
| ARWR / Arrowhead Pharmaceuticals, Inc. | 10.60 | -4.60 | 167.48 | 18.31 | 2.9330 | 0.7234 | |||
| MRUS / Merus N.V. | 3.16 | 5.19 | 165.98 | 31.45 | 2.9067 | 0.9358 | |||
| VERA / Vera Therapeutics, Inc. | 6.30 | 10.49 | 148.43 | 8.37 | 2.5993 | 0.4615 | |||
| FOLD / Amicus Therapeutics, Inc. | 18.00 | -12.20 | 103.14 | -38.34 | 1.8062 | -0.8049 | |||
| ALKS / Alkermes plc | 2.90 | 18.37 | 82.97 | 2.56 | 1.4530 | 0.1902 | |||
| OCUL / Ocular Therapeutix, Inc. | 7.40 | -8.19 | 68.67 | 16.24 | 1.2026 | 0.2804 | |||
| ETNB / 89bio, Inc. | 6.75 | 6.30 | 66.28 | 43.59 | 1.1608 | 0.4402 | |||
| CNTA / Centessa Pharmaceuticals plc - Depositary Receipt (Common Stock) | 5.00 | 23.46 | 65.70 | 12.81 | 1.1506 | 0.2415 | |||
| QURE / uniQure N.V. | 3.62 | 66.67 | 50.53 | 119.18 | 0.8849 | 0.5251 | |||
| TSHA / Taysha Gene Therapies, Inc. | 21.70 | 8.50 | 50.13 | 80.32 | 0.8778 | 0.4439 | |||
| BPMC / Blueprint Medicines Corporation | 0.38 | -90.26 | 48.07 | -85.89 | 0.8418 | -4.4772 | |||
| TRML / Tourmaline Bio, Inc. | 2.56 | 5.38 | 40.86 | 10.79 | 0.7156 | 0.1399 | |||
| BCRX / BioCryst Pharmaceuticals, Inc. | 4.50 | -48.28 | 40.32 | -38.21 | 0.7061 | -0.3124 | |||
| MNKD / MannKind Corporation | 5.85 | -33.14 | 21.88 | -50.29 | 0.3832 | -0.3038 | |||
| GLUE / Monte Rosa Therapeutics, Inc. | 3.73 | -19.82 | 16.80 | -22.06 | 0.2942 | -0.0423 | |||
| SEPN / Septerna, Inc. | 1.24 | -7.48 | 13.08 | 68.90 | 0.2291 | 0.1082 | |||
| RARE / Ultragenyx Pharmaceutical Inc. | 0.33 | -60.24 | 12.00 | -60.08 | 0.2101 | -0.2590 | |||
| WHWK / Whitehawk Therapeutics, Inc. | 2.85 | 0.00 | 5.33 | 5.07 | 0.0933 | 0.0141 | |||
| PCVX / Vaxcyte, Inc. | 0.00 | -100.00 | 0.00 | 0.0000 | |||||
| SRPT / Sarepta Therapeutics, Inc. | 0.00 | -100.00 | 0.00 | 0.0000 | |||||
| AUTL / Autolus Therapeutics plc - Depositary Receipt (Common Stock) | 0.00 | -100.00 | 0.00 | 0.0000 | |||||
| ITCI / Intra-Cellular Therapies, Inc. | 0.00 | -100.00 | 0.00 | 0.0000 |
