Monte Rosa Therapeutics, Inc.
US ˙ NasdaqGS ˙ US61225M1027

Introduction

This page provides a comprehensive analysis of the known insider trading history of Edward T Mathers. Insiders are officers, directors, or significant investors in a company. It is illegal for insiders to make trades in their companies based on specific, non-public information. This does not mean it is illegal for them to make any trades in their own companies. However, they must report all trades to the SEC via a Form 4. Despite these restrictions, academic research suggests that insiders - in general - tend to outperform the market in their own companies.

Average Trade Profitability

The average trade profitability is the average return of all the open market purchases made by the insider in the last three years. To calculate this, we examine every open-market, unplanned purchase made by the insider, excluding all trades that were marked as part of a 10b5-1 trading plan. We then calculate the average performance of those trades over 3, 6, and 12 months, averaging each of those durations to generate a final performance metric for each trade. Finally, we average all of the performance metrics to calculate a performance metric for the insider. This list only includes insiders that have made at least three trades in the last two years.

If this insiders trade profitability is "N/A", then the insider either has not made any open-market purchases in the last three years, or the trades they’ve made are too recent to calculate a reliable performance metric.

Update Frequency: Daily

See the list of most profitable insider traders.

Companies with Reported Insider Positions

The SEC filings indicate Edward T Mathers has reported holdings or trades in the following companies:

Security Title Latest Reported Holdings
Director 7,274
US:RYTM / Rhythm Pharmaceuticals, Inc. Director 7,000
Director, 10% Owner 3,614,486
US:KRRO / Korro Bio, Inc. 10% Owner 1,090,793
US:SVRA / Savara Inc. 10% Owner 24,471,264
US:TRVI / Trevi Therapeutics, Inc. Director 3,000,000
US:BHG / Bright Health Group, Inc. 10% Owner 23,983,073
US:GLUE / Monte Rosa Therapeutics, Inc. 10% Owner 0
US:AKUS / Akouos Inc Director 16,000
US:INZY / Inozyme Pharma, Inc. Director 9,367
US:SYBX / Synlogic, Inc. Director 15,000
US:MIRM / Mirum Pharmaceuticals, Inc. Director 17,000
US:RARX / Ra Pharmaceuticals, Inc. Director 0
Director 26,986
How to Interpret the Charts

The following charts show the stock performance of securities subsequent to each open-market, non-planned trade made by Edward T Mathers. Non-planned trade are trades that were not made as part of a 10b5-1 trading plan. The stock performance is charted as cumulative percent change in share price. For example, if an insider trade was made on January 1, 2019, the chart will show the daily percent change of the security to the present day. If the share price were to go from $10 to $15 during this time, the cumulative percent change in share price would be 50%. A change in price from $10 to $20 would be 100%, and a change in price of $10 to $5 would be -50%.

Ultimately, we are trying to determine how closely the insider’s trades correlate to excess returns (positive or negative) in the share price in order to see if the insider is timing their trades to profit from insider information. Consider the situation where an insider was doing this. In this situation, we would expect either (a) positive returns after purchases, or (b) negative returns after sales. In the case of (a), the PURCHASE chart would show a series of upwardly sloping curves, indicating positive returns after each purchase transaction. In the case of (b), the SALE chart would show a series of downward sloping curves, indicating negative returns after each sale transaction.

However, this alone is not enough to draw conclusions. If, for example, the share price of the company was in a non-cyclical climb over many years, then we would expect all the post-purchase plots to be upwardly sloping. Likewise, non-cyclical declines over many years would result in downward sloping post-trade plots. Neither of these charts would suggest insider trading activity.

The strongest indicator would be a situation where the share price was extremely cyclical, and there were both positive signals in the PURCHASE chart and negative plots on the SALE chart. This situation would be highly suggestive of an insider that was timing trades to their financial advantage.

Insider Purchases GLUE / Monte Rosa Therapeutics, Inc. - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made in GLUE / Monte Rosa Therapeutics, Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Max
Price at
Max
Max
Profit ($)
Max Return (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

GLUE / Monte Rosa Therapeutics, Inc. Insider Trades
Insider Sales GLUE / Monte Rosa Therapeutics, Inc. - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in GLUE / Monte Rosa Therapeutics, Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market sales that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Min
Price at
Min
Max Loss
Avoided ($)
Max Loss
Avoided (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

GLUE / Monte Rosa Therapeutics, Inc. Insider Trades
Insider Purchases KRRO / Korro Bio, Inc. - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made in GLUE / Monte Rosa Therapeutics, Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Max
Price at
Max
Max
Profit ($)
Max Return (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

KRRO / Korro Bio, Inc. Insider Trades
Insider Sales KRRO / Korro Bio, Inc. - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in GLUE / Monte Rosa Therapeutics, Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market sales that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Min
Price at
Min
Max Loss
Avoided ($)
Max Loss
Avoided (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

KRRO / Korro Bio, Inc. Insider Trades
Insider Purchases MIRM / Mirum Pharmaceuticals, Inc. - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made in GLUE / Monte Rosa Therapeutics, Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Max
Price at
Max
Max
Profit ($)
Max Return (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

MIRM / Mirum Pharmaceuticals, Inc. Insider Trades
Insider Sales MIRM / Mirum Pharmaceuticals, Inc. - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in GLUE / Monte Rosa Therapeutics, Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market sales that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Min
Price at
Min
Max Loss
Avoided ($)
Max Loss
Avoided (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

MIRM / Mirum Pharmaceuticals, Inc. Insider Trades
Insider Purchases MSTX / Tidal Trust II - Defiance Daily Target 2X Long MSTR ETF - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made in GLUE / Monte Rosa Therapeutics, Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Max
Price at
Max
Max
Profit ($)
Max Return (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

MSTX / Tidal Trust II - Defiance Daily Target 2X Long MSTR ETF Insider Trades
Insider Sales MSTX / Tidal Trust II - Defiance Daily Target 2X Long MSTR ETF - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in GLUE / Monte Rosa Therapeutics, Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market sales that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Min
Price at
Min
Max Loss
Avoided ($)
Max Loss
Avoided (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

MSTX / Tidal Trust II - Defiance Daily Target 2X Long MSTR ETF Insider Trades
Insider Purchases RYTM / Rhythm Pharmaceuticals, Inc. - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made in GLUE / Monte Rosa Therapeutics, Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Max
Price at
Max
Max
Profit ($)
Max Return (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

RYTM / Rhythm Pharmaceuticals, Inc. Insider Trades
Insider Sales RYTM / Rhythm Pharmaceuticals, Inc. - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in GLUE / Monte Rosa Therapeutics, Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market sales that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Min
Price at
Min
Max Loss
Avoided ($)
Max Loss
Avoided (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

RYTM / Rhythm Pharmaceuticals, Inc. Insider Trades
Insider Purchases SYBX / Synlogic, Inc. - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made in GLUE / Monte Rosa Therapeutics, Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Max
Price at
Max
Max
Profit ($)
Max Return (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

SYBX / Synlogic, Inc. Insider Trades
Insider Sales SYBX / Synlogic, Inc. - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in GLUE / Monte Rosa Therapeutics, Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market sales that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Min
Price at
Min
Max Loss
Avoided ($)
Max Loss
Avoided (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

SYBX / Synlogic, Inc. Insider Trades
Insider Purchases TRVI / Trevi Therapeutics, Inc. - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made in GLUE / Monte Rosa Therapeutics, Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Max
Price at
Max
Max
Profit ($)
Max Return (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

TRVI / Trevi Therapeutics, Inc. Insider Trades
Insider Sales TRVI / Trevi Therapeutics, Inc. - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in GLUE / Monte Rosa Therapeutics, Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market sales that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Min
Price at
Min
Max Loss
Avoided ($)
Max Loss
Avoided (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

TRVI / Trevi Therapeutics, Inc. Insider Trades
Insider Trading History

This table shows the complete list of insider trades made by Edward T Mathers as disclosed to the Securities Exchange Commission (SEC).

File Date Tran Date Form Ticker Security Code 10b5-1 Shares Remaining Shares Percent
Change
Share
Price
Tran
Value
Remaining
Value
2025-07-02 2025-06-30 4 OKUR OnKure Therapeutics, Inc.
Class A Common Stock
A - Award 4,694 7,274 181.94
2025-06-23 2025-06-18 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Common Stock
M - Exercise 4,000 7,000 133.33
2025-04-02 2025-03-31 4 OKUR OnKure Therapeutics, Inc.
Class A Common Stock
A - Award 2,580 2,580
2024-09-17 2024-09-16 4 MBX MBX Biosciences, Inc.
Common Stock
P - Purchase 500,000 3,614,486 16.05 16.00 8,000,000 57,831,776
2024-09-17 2024-09-16 4 MBX MBX Biosciences, Inc.
Common Stock
C - Conversion 2,091,383 3,114,486 204.42
2024-09-17 2024-09-16 4 MBX MBX Biosciences, Inc.
Common Stock
C - Conversion 1,023,103 1,023,103
2024-06-25 2024-06-21 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Common Stock
M - Exercise 3,000 3,000
2024-04-24 2024-04-22 4 KRRO Korro Bio, Inc.
Common Stock
P - Purchase 17,857 1,090,793 1.66 56.00 999,992 61,084,408
2023-11-07 3 KRRO Korro Bio, Inc.
Common Stock
1,072,936
2023-07-19 2023-07-17 4 SVRA Savara Inc
Common Stock
P - Purchase 333,333 24,471,264 1.38 3.00 999,999 73,413,792
2023-03-06 2023-03-02 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Common Stock
J - Other 5,771 5,771
2022-04-13 2022-04-11 4 TRVI Trevi Therapeutics, Inc.
Pre-Funded Warrants
A - Award 3,000,000 3,000,000 1.90 5,697,000 5,697,000
2022-04-13 2022-04-11 4 TRVI Trevi Therapeutics, Inc.
Common Stock
A - Award 948,948 948,948 1.90 1,803,001 1,803,001
2022-01-05 3 BHG Bright Health Group Inc.
Common Stock
23,983,073
2021-06-30 2021-06-28 4 GLUE Monte Rosa Therapeutics, Inc.
Series C convertible preferred Stock
C - Conversion -2,361,912 0 -100.00
2021-06-30 2021-06-28 4 GLUE Monte Rosa Therapeutics, Inc.
Series B convertible preferred stock
C - Conversion -11,500,000 0 -100.00
2021-06-30 2021-06-28 4 GLUE Monte Rosa Therapeutics, Inc.
Series A-2 convertible preferred stock
C - Conversion -9,588,725 0 -100.00
2021-06-30 2021-06-28 4 GLUE Monte Rosa Therapeutics, Inc.
Common Stock
P - Purchase 1,050,000 7,692,298 15.81 19.00 19,950,000 146,153,662
2021-06-30 2021-06-28 4 GLUE Monte Rosa Therapeutics, Inc.
Common Stock
C - Conversion 669,002 6,642,298 11.20
2021-06-30 2021-06-28 4 GLUE Monte Rosa Therapeutics, Inc.
Common Stock
C - Conversion 3,257,328 5,973,296 119.93
2021-06-30 2021-06-28 4 GLUE Monte Rosa Therapeutics, Inc.
Common Stock
C - Conversion 2,715,968 2,715,968
2021-06-25 2021-06-24 4 AKUS Akouos, Inc.
Stock Option (right to buy)
A - Award 16,000 16,000
2021-06-24 2021-06-23 4 INZY Inozyme Pharma, Inc.
Stock Option (right to buy)
A - Award 9,367 9,367
2021-06-17 2021-06-16 4 TRVI Trevi Therapeutics, Inc.
Nonstatutory Stock Option (right to buy)
A - Award 20,000 20,000
2021-06-16 2021-06-09 4/A RYTM RHYTHM PHARMACEUTICALS, INC.
Stock Option (right to buy)
A - Award 15,000 15,000
2021-06-14 2021-06-10 4 SYBX SYNLOGIC, INC.
Stock Option (right to buy)
A - Award 15,000 15,000
2021-06-11 2021-06-09 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Stock Option (right to buy)
A - Award 15,000 15,000
2021-06-08 2021-06-04 4 MIRM Mirum Pharmaceuticals, Inc.
Stock Option (right to buy)
A - Award 17,000 17,000
2021-04-12 2021-04-08 4 RPHM Reneo Pharmaceuticals, Inc.
Stock Option (right to buy)
A - Award 14,000 14,000
2021-03-16 3 SVRA Savara Inc
Common Stock
24,137,931
2020-07-24 2020-07-23 4 INZY Inozyme Pharma, Inc.
Stock Option (right to buy)
A - Award 9,367 9,367
2020-06-18 2020-06-17 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Stock Option (right to buy)
A - Award 18,500 18,500
2020-06-15 2020-06-11 4 MIRM Mirum Pharmaceuticals, Inc.
Stock Option (right to buy)
A - Award 17,000 17,000
2020-06-15 2020-06-11 4 TRVI Trevi Therapeutics, Inc.
Nonstatutory Stock Option (right to buy)
A - Award 14,210 14,210
2020-06-08 2020-06-04 4 SYBX SYNLOGIC, INC.
Stock Option (right to buy)
A - Award 15,000 15,000
2020-04-03 2020-04-02 4 RARX Ra Pharmaceuticals, Inc.
Stock Option (Right to Buy)
D - Sale to Issuer -15,000 0 -100.00
2020-04-03 2020-04-02 4 RARX Ra Pharmaceuticals, Inc.
Stock Option (Right to Buy)
D - Sale to Issuer -15,000 0 -100.00
2020-04-03 2020-04-02 4 RARX Ra Pharmaceuticals, Inc.
Stock Option (Right to Buy)
D - Sale to Issuer -15,000 0 -100.00
2019-06-21 2019-06-19 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Stock Option (right to buy)
A - Award 15,000 15,000
2019-06-13 2019-06-11 4 RARX Ra Pharmaceuticals, Inc.
Option to Purchase Common Stock
A - Award 15,000 15,000
2019-06-07 2019-06-05 4 SYBX SYNLOGIC, INC.
Stock Option (right to buy)
A - Award 10,000 10,000
2019-05-08 2019-05-07 4 TRVI Trevi Therapeutics, Inc.
Stock Option (right to buy)
A - Award 23,684 23,684
2018-07-27 2018-07-25 4 LQDA Liquidia Technologies Inc
Stock Option
A - Award 26,986 26,986
2018-07-02 2018-06-28 4 RARX Ra Pharmaceuticals, Inc.
Options to Purchase Common Stock
A - Award 15,000 15,000
2018-06-14 2018-06-13 4 SYBX SYNLOGIC, INC.
Stock Option (right to buy)
A - Award 10,000 10,000
2018-06-08 2018-06-06 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Stock Option (right to buy)
A - Award 10,000 10,000
2018-01-03 2017-12-29 4 SYBX SYNLOGIC, INC.
Stock Option (right to buy)
A - Award 18,572 18,572
2017-08-30 2017-08-28 4 SYBX SYNLOGIC, INC.
Stock Option (right to buy)
A - Award 1,428 1,428
2017-06-22 2017-06-20 4 RARX Ra Pharmaceuticals, Inc.
Options to Purchase Common Stock
A - Award 15,000 15,000
2016-09-06 2016-06-29 4 MIRN Mirna Therapeutics, Inc.
Stock Option (Right to Buy)
A - Award 10,000 10,000
2015-09-30 2015-09-30 4 MIRN Mirna Therapeutics, Inc.
Stock Option (Right to Buy)
A - Award 7,200 7,200
P
Open market or private purchase of non-derivative or derivative security
S
Open market or private sale of non-derivative or derivative security
A
Grant, award, or other acquisition of securities from the company (such as an option)
C
Conversion of derivative
D
Sale or transfer of securities back to the company
F
Payment of exercise price or tax liability using portion of securities received from the company
G
Gift of securities by or to the insider
K
Equity swaps and similar hedging transactions
M
Exercise or conversion of derivative security received from the company (such as an option)
V
A transaction voluntarily reported on Form 4
J
Other (accompanied by a footnote describing the transaction)