Hyperion DeFi, Inc.
US ˙ NasdaqCM ˙ US30234E1047

Introduction

This page provides a comprehensive analysis of the known insider trading history of Ernest Mario. Insiders are officers, directors, or significant investors in a company. It is illegal for insiders to make trades in their companies based on specific, non-public information. This does not mean it is illegal for them to make any trades in their own companies. However, they must report all trades to the SEC via a Form 4. Despite these restrictions, academic research suggests that insiders - in general - tend to outperform the market in their own companies.

Average Trade Profitability

The average trade profitability is the average return of all the open market purchases made by the insider in the last three years. To calculate this, we examine every open-market, unplanned purchase made by the insider, excluding all trades that were marked as part of a 10b5-1 trading plan. We then calculate the average performance of those trades over 3, 6, and 12 months, averaging each of those durations to generate a final performance metric for each trade. Finally, we average all of the performance metrics to calculate a performance metric for the insider. This list only includes insiders that have made at least three trades in the last two years.

If this insiders trade profitability is "N/A", then the insider either has not made any open-market purchases in the last three years, or the trades they’ve made are too recent to calculate a reliable performance metric.

Update Frequency: Daily

See the list of most profitable insider traders.

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Companies with Reported Insider Positions

The SEC filings indicate Ernest Mario has reported holdings or trades in the following companies:

Security Title Latest Reported Holdings
US:SLNO / Soleno Therapeutics, Inc. Director 193,066
US:EYEN / Eyenovia, Inc. Director 9,653
Director 49,000
US:CELG / Celgene Corp. Director 0
US:TNXP / Tonix Pharmaceuticals Holding Corp. Director 50,000
US:CMRX / Chimerix, Inc. Director 108,167
US:BSX / Boston Scientific Corporation Director 86,032
US:XNPT / XenoPort, Inc. Director 0
US:928551AA8 / VIVUS, Inc. Bond Director 81,125
US:MAXY / Maxygen Inc Director 62,964
How to Interpret the Charts

The following charts show the stock performance of securities subsequent to each open-market, non-planned trade made by Ernest Mario. Non-planned trade are trades that were not made as part of a 10b5-1 trading plan. The stock performance is charted as cumulative percent change in share price. For example, if an insider trade was made on January 1, 2019, the chart will show the daily percent change of the security to the present day. If the share price were to go from $10 to $15 during this time, the cumulative percent change in share price would be 50%. A change in price from $10 to $20 would be 100%, and a change in price of $10 to $5 would be -50%.

Ultimately, we are trying to determine how closely the insider’s trades correlate to excess returns (positive or negative) in the share price in order to see if the insider is timing their trades to profit from insider information. Consider the situation where an insider was doing this. In this situation, we would expect either (a) positive returns after purchases, or (b) negative returns after sales. In the case of (a), the PURCHASE chart would show a series of upwardly sloping curves, indicating positive returns after each purchase transaction. In the case of (b), the SALE chart would show a series of downward sloping curves, indicating negative returns after each sale transaction.

However, this alone is not enough to draw conclusions. If, for example, the share price of the company was in a non-cyclical climb over many years, then we would expect all the post-purchase plots to be upwardly sloping. Likewise, non-cyclical declines over many years would result in downward sloping post-trade plots. Neither of these charts would suggest insider trading activity.

The strongest indicator would be a situation where the share price was extremely cyclical, and there were both positive signals in the PURCHASE chart and negative plots on the SALE chart. This situation would be highly suggestive of an insider that was timing trades to their financial advantage.

Insider Purchases HYPD / Hyperion DeFi, Inc. - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made in HYPD / Hyperion DeFi, Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares		 Reported
Price		 Adjusted
Shares		 Adjusted
Price		 Cost Basis Days to
Max		 Price at
Max		 Max
Profit ($)		 Max Return (%)
2020-03-24 EYEN MARIO ERNEST 82,431 2.2700 1,030 181.6000 187,118 329 7.41 -179,486 -95.92
2019-07-11 EYEN MARIO ERNEST 35,971 2.7800 450 222.4000 99,999
2018-01-29 EYEN MARIO ERNEST 90,000 10.0000 1,125 800.0000 900,000

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

HYPD / Hyperion DeFi, Inc. Insider Trades
Insider Sales HYPD / Hyperion DeFi, Inc. - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in HYPD / Hyperion DeFi, Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market sales that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares		 Reported
Price		 Adjusted
Shares		 Adjusted
Price		 Cost Basis Days to
Min		 Price at
Min		 Max Loss
Avoided ($)		 Max Loss
Avoided (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

HYPD / Hyperion DeFi, Inc. Insider Trades
Insider Purchases SLNO / Soleno Therapeutics, Inc. - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made in HYPD / Hyperion DeFi, Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares		 Reported
Price		 Adjusted
Shares		 Adjusted
Price		 Cost Basis Days to
Max		 Price at
Max		 Max
Profit ($)		 Max Return (%)
2022-03-31 SLNO MARIO ERNEST 930,000 62,000 306 2.9100
2022-03-31 SLNO MARIO ERNEST 930,000 62,000
2016-06-08 CAPN MARIO ERNEST 50,000 1.2400 5,000 12.4000 62,000
2016-06-08 CAPN MARIO ERNEST 50,000 1.2400 5,000 12.4000 62,000
2016-05-20 CAPN MARIO ERNEST 5,637 1.2000 564 12.0000 6,764
2016-05-20 CAPN MARIO ERNEST 5,637 1.2000 564 12.0000 6,764
2016-05-19 CAPN MARIO ERNEST 43,169 1.1785 4,317 11.7850 50,875
2016-05-19 CAPN MARIO ERNEST 43,169 1.1785 4,317 11.7850 50,875
2015-11-18 CAPN MARIO ERNEST 50,000 1.7700 5,000 17.7000 88,500
2015-09-14 CAPN MARIO ERNEST 15,000 2.2800 1,500 22.8000 34,200
2015-08-21 CAPN MARIO ERNEST 16,228 1.9100 1,623 19.1000 30,995
2015-08-12 CAPN MARIO ERNEST 10,000 1.6440 1,000 16.4400 16,440
2015-08-11 CAPN MARIO ERNEST 50,000 1.7700 5,000 17.7000 88,500
2014-11-18 CAPN MARIO ERNEST 96,803 9,680
2014-11-18 CAPN MARIO ERNEST 53,512 5,351
2014-11-18 CAPN MARIO ERNEST 114,072 11,407
2014-11-18 CAPN MARIO ERNEST 44,770 4,477
2014-11-18 CAPN MARIO ERNEST 253,846 25,385

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

SLNO / Soleno Therapeutics, Inc. Insider Trades
Insider Sales SLNO / Soleno Therapeutics, Inc. - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in HYPD / Hyperion DeFi, Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market sales that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares		 Reported
Price		 Adjusted
Shares		 Adjusted
Price		 Cost Basis Days to
Min		 Price at
Min		 Max Loss
Avoided ($)		 Max Loss
Avoided (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

SLNO / Soleno Therapeutics, Inc. Insider Trades
Insider Trading History

This table shows the complete list of insider trades made by Ernest Mario as disclosed to the Securities Exchange Commission (SEC).

File Date Tran Date Form Ticker Security Code 10b5-1 Shares Remaining Shares Percent
Change		 Share
Price		 Tran
Value		 Remaining
Value
2024-06-10 2024-06-06 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 6,500 193,066 3.48
2024-05-23 2024-05-21 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		X - Other 62,000 186,566 49.77 4.50 279,000 839,547
2024-01-10 2024-01-08 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		G - Gift -3,523 124,566 -2.75
2023-12-04 2023-11-30 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		G - Gift -8,700 128,089 -6.36
2022-04-04 2022-03-31 4 SLNO SOLENO THERAPEUTICS INC
Warrant (right to buy) 		P - Purchase 930,000 930,000
2022-04-04 2022-03-31 4 SLNO SOLENO THERAPEUTICS INC
Warrant (right to buy) 		P - Purchase 930,000 930,000
2022-04-04 2022-03-31 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		P - Purchase 930,000 930,000
2022-04-04 2022-03-31 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		P - Purchase 930,000 930,000
2022-02-02 2022-01-31 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 56,338 1,433,135 4.09 0.36 20,000 508,763
2021-11-22 2021-11-17 4 EYEN EYENOVIA, INC.
Stock Option (right to buy) 		A - Award 9,653 9,653
2021-11-22 2021-11-17 4 EYEN EYENOVIA, INC.
Common Stock, par value $.0001 		A - Award 6,963 382,706 1.85
2021-11-02 2021-10-29 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 26,888 1,376,797 1.99
2021-08-03 2021-07-30 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 21,978 1,349,909 1.66 0.91 20,000 1,228,417
2021-06-04 2021-06-01 4 SLNO SOLENO THERAPEUTICS INC
Employee stock option (right to buy) 		A - Award 31,862 31,862
2021-05-04 2021-04-30 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 16,529 1,176,416 1.43 1.21 20,000 1,423,463
2021-02-02 2021-01-29 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 8,928 1,157,804 0.78
2021-01-22 2021-01-20 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		A - Award 49,000 49,000
2021-01-19 2021-01-15 4 EYEN EYENOVIA, INC.
Class A Warrant 		X - Other -41,216 0 -100.00
2021-01-19 2021-01-15 4 EYEN EYENOVIA, INC.
Common Stock, par value $.0001 		X - Other 41,216 375,743 12.32 2.27 93,560 852,937
2021-01-12 2021-01-08 4 SLNO SOLENO THERAPEUTICS INC
Employee stock option (right to buy) 		A - Award 40,000 40,000
2020-11-03 2020-10-30 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 10,057 1,148,876 0.88 1.74 17,499 1,999,044
2020-09-15 2020-09-11 4 EYEN EYENOVIA, INC.
Stock Option (right to buy) 		A - Award 9,820 9,820
2020-09-15 2020-09-11 4 EYEN EYENOVIA, INC.
Common Stock, par value $.0001 		A - Award 7,288 334,527 2.23
2020-08-03 2020-07-31 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 10,174 10,174 1.72 17,499 17,499
2020-05-20 2020-05-18 4 SLNO SOLENO THERAPEUTICS INC
Employee stock option (right to buy) 		A - Award 9,530 9,530
2020-05-04 2020-04-30 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 5,738 5,738 3.05 17,501 17,501
2020-03-26 2020-03-24 4 EYEN EYENOVIA, INC.
Class B Warrant 		P - Purchase 61,823 61,823
2020-03-26 2020-03-24 4 EYEN EYENOVIA, INC.
Class A Warrant 		P - Purchase 41,216 41,216
2020-03-26 2020-03-24 4 EYEN EYENOVIA, INC.
Common Stock, par value $.0001 		P - Purchase 82,431 327,239 33.67 2.27 187,118 742,833
2020-01-24 2020-01-22 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 10,448 10,448 3.35 35,001 35,001
2020-01-22 2020-01-17 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		A - Award 49,000 49,000
2019-11-22 2019-11-20 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		D - Sale to Issuer -4,756 0 -100.00
2019-11-22 2019-11-20 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		D - Sale to Issuer -970 0 -100.00
2019-11-22 2019-11-20 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		D - Sale to Issuer -300 0 -100.00
2019-11-22 2019-11-20 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		D - Sale to Issuer -13,266 0 -100.00
2019-11-22 2019-11-20 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		D - Sale to Issuer -10,500 0 -100.00
2019-11-22 2019-11-20 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		D - Sale to Issuer -11,000 0 -100.00
2019-11-22 2019-11-20 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		D - Sale to Issuer -10,000 0 -100.00
2019-11-22 2019-11-20 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		D - Sale to Issuer -20,700 0 -100.00
2019-11-22 2019-11-20 4 CELG CELGENE CORP /DE/
Common Stock 		D - Sale to Issuer -4,908 0 -100.00
2019-11-22 2019-11-20 4 CELG CELGENE CORP /DE/
Common Stock 		D - Sale to Issuer -62,884 0 -100.00
2019-08-20 2019-08-16 4 EYEN EYENOVIA, INC.
Stock Option (right to buy) 		A - Award 9,057 9,057
2019-08-20 2019-08-16 4 EYEN EYENOVIA, INC.
Common Stock, par value $.0001 		A - Award 8,038 280,779 2.95
2019-07-15 2019-07-11 4 EYEN EYENOVIA, INC.
Common Stock, par value $.0001 		P - Purchase 35,971 272,741 15.19 2.78 99,999 758,220
2019-06-17 2019-06-15 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -375 0 -100.00
2019-06-17 2019-06-15 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 375 62,884 0.60
2019-06-17 2019-06-14 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -300 300 -50.00
2019-06-17 2019-06-14 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 300 62,509 0.48
2019-06-17 2019-06-13 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -484 970 -33.29
2019-06-17 2019-06-13 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 484 62,209 0.78
2019-06-12 2019-06-10 4 SLNO SOLENO THERAPEUTICS INC
Employee stock option (right to buy) 		A - Award 13,000 13,000
2019-06-05 2019-06-03 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		A - Award 4,756 4,756
2019-05-21 2018-01-29 4 EYEN EYENOVIA, INC.
Common Stock, par value $.0001 		P - Purchase 90,000 236,770 61.32 10.00 900,000 2,367,700
2019-03-07 2019-03-05 4 CELG CELGENE CORP /DE/
Common Stock 		J - Other 2,908 4,908 145.40 85.97 250,001 421,941
2019-03-07 2019-03-05 4 CELG CELGENE CORP /DE/
Common Stock 		J - Other -2,908 55,005 -5.02 85.97 -250,001 4,728,780
2019-02-14 2019-02-12 4 CELG CELGENE CORP /DE/
Common Stock 		P - Purchase 2,000 2,000 89.99 179,980 179,980
2019-02-14 2019-01-14 4 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -5,100 57,913 -8.09
2019-02-05 2019-02-01 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		A - Award 49,000 49,000
2018-12-20 2018-12-19 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -8,600 0 -100.00
2018-12-20 2018-12-19 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 8,600 63,013 15.81 59.06 507,873 3,721,233
2018-11-28 2018-11-26 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -10,000 8,600 -53.76
2018-11-28 2018-11-26 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 10,000 54,413 22.52 59.06 590,550 3,213,360
2018-10-31 2018-10-29 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		M - Exercise -44,000 0 -100.00
2018-10-31 2018-10-29 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		M - Exercise -833 0 -100.00
2018-10-31 2018-10-29 4 KIN Kindred Biosciences, Inc.
Common Stock 		M - Exercise 44,000 169,000 35.20 3.45 151,800 583,050
2018-10-31 2018-10-29 4 KIN Kindred Biosciences, Inc.
Common Stock 		M - Exercise 833 125,000 0.67 1.37 1,141 171,250
2018-08-13 2018-08-09 4 CELG CELGENE CORP /DE/
Common Stock 		S - Sale -12,000 44,413 -21.27 92.32 -1,107,888 4,100,386
2018-07-26 2018-07-24 4 EYEN EYENOVIA, INC.
Stock Option (right to buy) 		A - Award 4,465 4,465
2018-07-26 2018-07-24 4 EYEN EYENOVIA, INC.
Common Stock, par value $.0001 		A - Award 4,033 146,770 2.83
2018-06-27 2018-06-25 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 16,500 50,000 49.25 4.48 73,920 224,000
2018-06-26 2018-06-22 4 KIN Kindred Biosciences, Inc.
Stock Option (Right to Buy) 		A - Award 10,000 10,000
2018-06-18 2018-06-17 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -334 0 -100.00
2018-06-18 2018-06-17 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 334 56,413 0.60
2018-06-18 2018-06-11 4 SLNO SOLENO THERAPEUTICS INC
Employee stock option (right to buy) 		A - Award 15,931 15,931
2018-06-15 2018-06-15 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -375 375 -50.00
2018-06-15 2018-06-15 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 375 56,079 0.67
2018-06-15 2018-06-14 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -300 600 -33.33
2018-06-15 2018-06-14 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 300 55,704 0.54
2018-06-15 2018-06-13 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		A - Award 13,266 13,266
2018-06-15 2018-06-13 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		A - Award 1,454 1,454
2018-06-13 2018-06-12 4 TNXP Tonix Pharmaceuticals Holding Corp.
Stock Option 		A - Award 20,000 20,000
2018-06-13 2018-06-13 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 3,606 475,324 0.76 2.04 7,356 969,661
2018-06-13 2018-06-11 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 500 471,718 0.11 2.04 1,020 962,305
2018-06-13 2018-06-11 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 4,980 471,218 1.07 2.05 10,209 965,997
2018-06-11 2018-06-08 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 14,803 466,238 3.28 2.04 30,257 952,990
2018-06-11 2018-06-07 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 4,611 451,435 1.03 2.00 9,234 903,999
2018-06-07 2018-06-05 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 1,200 446,824 0.27 2.05 2,460 915,989
2018-06-04 2018-06-01 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 1,300 445,624 0.29 2.05 2,665 913,529
2018-06-04 2018-05-31 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 500 444,324 0.11 2.05 1,025 910,864
2018-05-29 2018-05-29 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 500 443,824 0.11 2.01 1,005 892,086
2018-05-29 2018-05-25 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 5,000 443,324 1.14 2.05 10,250 908,814
2018-05-22 2018-05-21 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 5,000 438,324 1.15 1.94 9,720 852,102
2018-05-22 2018-05-21 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 25,000 433,324 6.12 1.95 48,750 844,982
2018-05-21 2018-05-18 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -15,000 108,167 -12.18 4.81 -72,142 520,229
2018-05-21 2018-05-17 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -30,000 123,167 -19.59 4.80 -143,931 590,918
2018-05-21 2018-05-18 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 25,000 408,324 6.52 1.90 47,500 775,816
2018-05-17 2018-05-16 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -30,000 153,167 -16.38 4.79 -143,808 734,221
2018-05-16 2018-05-15 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -30,000 183,167 -14.07 4.69 -140,808 859,713
2018-05-15 2018-05-14 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -22,553 213,167 -9.57 4.67 -105,232 994,637
2018-05-15 2018-05-11 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -22,857 235,720 -8.84 4.63 -105,766 1,090,747
2018-05-15 2018-05-11 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -7,143 258,577 -2.69 4.57 -32,614 1,180,637
2018-05-11 2018-05-10 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -2,815 265,720 -1.05 4.60 -12,949 1,222,312
2018-04-24 2018-04-20 4 KIN Kindred Biosciences, Inc.
Stock Option (Right to Buy) 		A - Award 44,603 44,603
2018-04-11 3 KIN Kindred Biosciences, Inc.
Common Stock 		248,334
2018-04-11 3 KIN Kindred Biosciences, Inc.
Common Stock 		248,334
2018-04-11 3 KIN Kindred Biosciences, Inc.
Common Stock 		248,334
2018-03-09 2018-02-09 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		G - Gift 10,000 33,500 42.55
2018-03-09 2018-02-09 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		G - Gift -10,000 0 -100.00
2018-03-09 2017-05-27 4 TNXP Tonix Pharmaceuticals Holding Corp.
Restricted Stock Units 		M - Exercise -750 0 -100.00
2018-03-09 2017-05-27 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		M - Exercise 750 64,572 1.18
2018-03-09 2017-02-09 4 TNXP Tonix Pharmaceuticals Holding Corp.
Restricted Stock Units 		M - Exercise -750 0 -100.00
2018-03-09 2017-02-09 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		M - Exercise 750 63,822 1.19
2018-03-09 2016-02-25 4 TNXP Tonix Pharmaceuticals Holding Corp.
Restricted Stock Units 		M - Exercise -600 0 -100.00
2018-03-09 2016-02-25 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		M - Exercise 600 26,648 2.30
2018-02-26 2018-02-23 4 CELG CELGENE CORP /DE/
Common Stock 		S - Sale -13,370 55,404 -19.44 94.49 -1,263,298 5,234,985
2018-02-26 2018-02-14 4 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -2,250 324 -87.41
2018-02-26 2018-02-14 4 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -2,250 324 -87.41
2018-02-07 2018-02-05 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 8,689 704,352 1.25 1.73 15,000 1,215,923
2018-01-24 3 EYEN EYENOVIA, INC.
Common Stock, par value $.0001 		285,474
2018-01-24 3 EYEN EYENOVIA, INC.
Common Stock, par value $.0001 		285,474
2017-12-22 2017-12-21 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		S - Sale -5,000 23,500 -17.54 3.46 -17,300 81,310
2017-12-22 2017-12-20 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		S - Sale -8,965 28,500 -23.93 3.44 -30,840 98,040
2017-12-22 2017-12-19 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		S - Sale -6,035 37,465 -13.87 3.51 -21,183 131,502
2017-12-22 2017-12-18 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		S - Sale -10,000 43,500 -18.69 3.57 -35,700 155,295
2017-12-22 2017-12-15 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		S - Sale -5,000 53,500 -8.55 3.55 -17,750 189,925
2017-12-22 2017-12-14 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		S - Sale -1,967 55,467 -3.42 3.58 -7,042 198,572
2017-11-01 2017-10-30 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -13,600 0 -100.00
2017-11-01 2017-10-30 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 13,600 71,024 23.68 31.80 432,412 2,258,208
2017-10-04 2017-10-02 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 28,846 1,873,174 1.56 0.52 15,000 974,050
2017-08-31 2017-02-27 4 CELG CELGENE CORP /DE/
Common Stock 		S - Sale -12,000 57,424 -17.29 121.24 -1,454,880 6,962,086
2017-08-14 2017-08-10 4 CELG CELGENE CORP /DE/
Common Stock 		S - Sale -18,506 69,424 -21.05 130.52 -2,415,403 9,061,220
2017-07-17 2017-07-16 4 SLNO SOLENO THERAPEUTICS INC
Common Stock 		A - Award 24,590 1,844,328 1.35 0.61 15,000 1,125,040
2017-07-05 2017-07-01 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -734 0 -100.00
2017-07-05 2017-07-01 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 734 87,930 0.84
2017-06-30 2017-06-30 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		S - Sale -6,105 5,895 -50.88 4.28 -26,117 25,219
2017-06-29 2017-06-28 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		A - Award 6,341 6,341
2017-06-29 2017-06-28 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		A - Award 21,000 21,000
2017-06-21 2017-06-20 4 TNXP Tonix Pharmaceuticals Holding Corp.
Stock Option 		A - Award 20,000 20,000
2017-06-20 2017-06-17 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -333 334 -49.93
2017-06-20 2017-06-17 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 333 87,196 0.38
2017-06-16 2017-06-15 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -375 750 -33.33
2017-06-16 2017-06-15 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 375 86,863 0.43
2017-06-16 2017-06-14 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		A - Award 900 900
2017-06-16 2017-06-14 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		A - Award 10,500 10,500
2017-06-16 2017-02-01 4 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -3,570 86,488 -3.96
2017-05-09 2017-05-08 4 CAPN Capnia, Inc.
Employee stock option (right to buy) 		A - Award 45,139 45,139
2017-04-13 2017-04-07 4 CAPN Capnia, Inc.
Common Stock 		A - Award 23,809 1,819,738 1.33 0.63 15,000 1,146,435
2017-04-13 2017-01-23 4 CAPN Capnia, Inc.
Common Stock 		A - Award 16,667 1,795,929 0.94 0.90 15,000 1,616,336
2017-01-31 2016-04-04 5 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -4,125 90,058 -4.38
2016-12-29 2016-12-28 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -20,291 268,535 -7.03 4.52 -91,634 1,212,704
2016-12-29 2016-12-28 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -4,000 288,826 -1.37 4.67 -18,683 1,349,020
2016-12-29 2016-12-27 4 CMRX CHIMERIX INC
Common Stock 		S - Sale -3,636 292,826 -1.23 4.65 -16,907 1,361,641
2016-12-29 2016-12-27 4 CMRX CHIMERIX INC
Common Stock 		S - Sale X -72,073 296,462 -19.56 4.68 -337,143 1,386,790
2016-11-28 2016-11-23 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 120,000 120,000 0.40 48,600 48,600
2016-10-31 2016-10-31 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock Purchase Warrant 		P - Purchase 100,000 100,000
2016-10-31 2016-10-31 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 100,000 630,724 18.84
2016-10-11 2016-10-06 4 CAPN Capnia, Inc.
Common Stock 		A - Award 15,625 1,779,262 0.89
2016-09-26 2016-09-23 4 CELG CELGENE CORP /DE/
Common Stock 		S - Sale -15,000 90,058 -14.28 109.42 -1,641,300 9,854,146
2016-09-14 2016-09-13 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 100,000 530,724 23.22 0.79 79,180 420,227
2016-08-19 2016-08-18 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 25,000 1,763,637 1.44 0.99 24,750 1,746,001
2016-08-19 2016-05-20 4/A CAPN Capnia, Inc.
Common Stock 		P - Purchase 5,637 1,688,637 0.33 1.20 6,764 2,026,364
2016-08-19 2016-05-19 4/A CAPN Capnia, Inc.
Common Stock 		P - Purchase 43,169 1,683,000 2.63 1.18 50,875 1,983,416
2016-08-19 2016-06-08 4/A CAPN Capnia, Inc.
Common Stock 		P - Purchase 50,000 1,738,637 2.96 1.24 62,000 2,155,910
2016-07-05 2016-07-01 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -733 734 -49.97
2016-07-05 2016-07-01 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 733 105,058 0.70
2016-06-28 2016-06-24 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		A - Award 9,634 9,634
2016-06-28 2016-06-24 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		A - Award 9,000 9,000
2016-06-28 2016-06-24 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 50,000 381,440 15.09 3.70 184,845 1,410,146
2016-06-21 2016-06-21 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 50,000 430,724 13.13 2.00 100,000 861,448
2016-06-17 2016-06-17 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -333 667 -33.30
2016-06-17 2016-06-17 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 333 104,325 0.32
2016-06-17 2016-06-15 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		A - Award 1,125 1,125
2016-06-17 2016-06-15 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		A - Award 11,000 11,000
2016-06-13 2016-06-12 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -2,068 0 -100.00
2016-06-13 2016-06-12 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 2,068 103,992 2.03
2016-06-10 2016-06-08 4 CAPN Capnia, Inc.
Employee stock option (right to buy) 		A - Award 27,083 27,083
2016-06-09 2016-06-08 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 50,000 1,918,637 2.68 1.24 62,000 2,379,110
2016-05-31 2016-05-27 4 TNXP Tonix Pharmaceuticals Holding Corp.
Restricted Stock Unit 		A - Award 7,500 7,500
2016-05-23 2016-05-20 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 5,637 1,868,637 0.30 1.20 6,764 2,242,364
2016-05-23 2016-05-19 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 43,169 1,863,000 2.37 1.18 50,875 2,195,546
2016-05-16 2016-05-13 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 10,000 331,440 3.11 4.53 45,328 1,502,351
2016-05-12 2016-05-12 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 31,042 380,724 8.88 2.30 71,356 875,170
2016-05-11 2016-05-11 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 8,210 349,682 2.40 2.24 18,399 783,672
2016-05-11 2016-05-11 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 24,200 321,440 8.14 4.85 117,365 1,558,920
2016-05-11 2016-05-10 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 800 297,240 0.27 4.76 3,804 1,413,376
2016-05-05 2016-05-04 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,761 15,845 -10.00
2016-05-05 2016-05-04 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,761 296,440 0.60 5.05 8,893 1,497,022
2016-04-28 2016-04-26 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -5,000 13,600 -26.88
2016-04-28 2016-04-26 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 5,000 101,924 5.16 31.80 158,975 3,240,674
2016-04-05 2016-04-04 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,760 17,606 -9.09
2016-04-05 2016-04-04 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,760 294,679 0.60 5.05 8,888 1,488,129
2016-03-17 2016-03-15 4 KIN Kindred Biosciences, Inc.
Common Stock 		P - Purchase 30,000 99,583 43.11 3.55 106,500 353,520
2016-03-17 2016-03-16 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 75,000 341,472 28.15 2.29 171,712 781,800
2016-03-16 2016-03-16 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 5,000 292,919 1.74 4.78 23,898 1,400,036
2016-03-16 2016-03-15 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 20,000 287,919 7.46 5.13 102,628 1,477,428
2016-03-09 2016-03-07 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,761 19,366 -8.34
2016-03-09 2016-03-07 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,761 267,919 0.66 5.05 8,893 1,352,991
2016-02-10 2016-02-09 4 TNXP Tonix Pharmaceuticals Holding Corp.
Restricted Stock Unit 		A - Award 7,500 7,500
2016-02-09 2016-02-08 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,760 21,127 -7.69
2016-02-09 2016-02-08 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,760 266,158 0.67 5.05 8,888 1,344,098
2016-02-02 2016-02-01 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -18,600 0 -100.00
2016-02-02 2016-02-01 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 18,600 101,049 22.56 29.00 539,400 2,930,421
2016-01-14 2016-01-13 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,761 22,887 -7.14
2016-01-14 2016-01-13 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,761 264,398 0.67 5.05 8,893 1,335,210
2016-01-12 2016-01-08 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		A - Award 44,000 44,000
2015-12-30 2015-12-29 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 125,000 262,637 90.82 7.09 886,612 1,862,858
2015-12-30 2015-12-28 4 CELG CELGENE CORP /DE/
Common Stock 		S - Sale -40,000 82,449 -32.67 119.36 -4,774,400 9,841,113
2015-12-11 2015-12-09 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,760 24,648 -6.66
2015-12-11 2015-12-09 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,760 137,637 1.30 5.05 8,888 695,067
2015-11-18 2015-11-18 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 50,000 1,639,831 3.14 1.77 88,500 2,902,501
2015-11-17 2015-11-16 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale -125,000 86,032 -59.23 17.63 -2,203,162 1,516,340
2015-11-10 2015-11-06 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,761 26,408 -6.25
2015-11-10 2015-11-06 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,761 135,877 1.31 5.05 8,893 686,179
2015-10-07 2015-10-06 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,761 28,169 -5.88
2015-10-07 2015-10-06 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,761 134,116 1.33 5.05 8,893 677,286
2015-09-14 2015-09-14 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 15,000 1,589,831 0.95 2.28 34,200 3,624,815
2015-09-08 2015-09-04 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -832 8,319 -9.09
2015-09-08 2015-09-04 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,760 29,930 -5.55
2015-09-08 2015-09-04 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 832 132,355 0.63 45.15 37,565 5,975,828
2015-09-08 2015-09-04 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,760 131,523 1.36 5.05 8,888 664,191
2015-08-27 2015-08-26 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 10,000 260,472 3.99 6.05 60,500 1,575,856
2015-08-26 2015-08-25 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 1,468 250,472 0.59 6.40 9,395 1,603,021
2015-08-25 2015-08-21 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 16,228 1,553,999 1.06 1.91 30,995 2,968,138
2015-08-25 2015-08-24 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 2,532 249,004 1.03 6.20 15,698 1,543,825
2015-08-20 2015-08-18 4 CAPN Capnia, Inc.
Warrant (right to buy) 		J - Other -50,000 0 -100.00
2015-08-20 2015-08-11 4 CAPN Capnia, Inc.
Common Stock 		J - Other 210,251 1,477,771 16.59
2015-08-20 2015-08-20 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 6,000 246,472 2.50 6.64 39,867 1,637,683
2015-08-20 2015-08-18 4/A CAPN Capnia, Inc.
Common Stock 		J - Other 210,251 1,537,771 15.84
2015-08-17 2015-08-17 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 15,000 240,472 6.65 6.93 104,018 1,667,553
2015-08-13 2015-08-12 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 10,000 1,327,520 0.76 1.64 16,440 2,182,443
2015-08-12 2015-08-11 4 CAPN Capnia, Inc.
Warrant (right to buy) 		J - Other -205,188 0 -100.00
2015-08-12 2015-08-11 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 50,000 1,317,520 3.94 1.77 88,500 2,332,010
2015-08-12 2015-08-11 4 CAPN Capnia, Inc.
Common Stock 		J - Other 786,645 1,267,520 163.59
2015-08-07 2015-08-06 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -832 9,151 -8.33
2015-08-07 2015-08-06 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -129 0 -100.00
2015-08-07 2015-08-06 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -750 0 -100.00
2015-08-07 2015-08-06 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -3,521 31,690 -10.00
2015-08-07 2015-08-06 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 832 129,763 0.65 45.15 37,565 5,858,799
2015-08-07 2015-08-06 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 129 128,931 0.10 23.26 3,001 2,998,935
2015-08-07 2015-08-06 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 750 128,802 0.59 23.26 17,445 2,995,935
2015-08-07 2015-08-06 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 3,521 128,052 2.83 5.05 17,781 646,663
2015-08-04 2015-07-31 4 CELG CELGENE CORP /DE/
Common Stock 		S - Sale -19,442 122,449 -13.70 131.73 -2,561,139 16,130,488
2015-07-17 2015-07-17 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 25,000 225,472 12.47 7.50 187,500 1,691,040
2015-07-06 2015-07-01 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -733 1,467 -33.32
2015-07-06 2015-07-01 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 733 141,891 0.52
2015-06-26 2015-06-25 4 CAPN Capnia, Inc.
Employee stock option (right to buy) 		M - Exercise -54,999 0 -100.00
2015-06-26 2015-06-25 4 CAPN Capnia, Inc.
Common Stock 		M - Exercise 54,999 480,875 12.91 3.48 191,397 1,673,445
2015-06-24 2015-06-22 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		A - Award 9,983 9,983
2015-06-19 2015-06-17 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		A - Award 1,000 1,000
2015-06-19 2015-06-17 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		A - Award 10,000 10,000
2015-06-16 2015-06-13 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -2,068 0 -100.00
2015-06-16 2015-06-13 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 2,068 141,158 1.49
2015-06-16 2015-06-12 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -2,066 2,068 -49.98
2015-06-16 2015-06-12 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 2,066 139,090 1.51
2015-06-11 2015-06-10 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -258 129 -66.67
2015-06-11 2015-06-10 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,500 750 -66.67
2015-06-11 2015-06-10 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -3,521 35,211 -9.09
2015-06-11 2015-06-10 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 258 124,531 0.21 23.26 6,001 2,896,591
2015-06-11 2015-06-10 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,500 124,273 1.22 23.26 34,890 2,890,590
2015-06-11 2015-06-10 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 3,521 122,773 2.95 5.05 17,781 620,004
2015-06-08 2015-06-04 4 CAPN Capnia, Inc.
Employee stock option (right to buy) 		M - Exercise -25,000 54,999 -31.25
2015-06-08 2015-06-04 4 CAPN Capnia, Inc.
Common Stock 		M - Exercise 25,000 425,876 6.24 3.48 87,000 1,482,048
2015-06-04 2015-06-02 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		M - Exercise 8,750 11,250 350.00
2015-06-04 2015-06-02 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		M - Exercise 8,333 14,167 142.84
2015-06-04 2015-06-02 4 KIN Kindred Biosciences, Inc.
Common Stock 		M - Exercise 8,750 69,583 14.38 1.37 11,988 95,329
2015-06-04 2015-06-02 4 KIN Kindred Biosciences, Inc.
Common STock 		M - Exercise 8,333 60,833 15.87 0.32 2,667 19,467
2015-05-21 2015-05-19 4 XNPT XENOPORT INC
Non-Employee Restricted Stock Unit 		M - Exercise -5,000 0 -100.00
2015-05-21 2015-05-19 4 XNPT XENOPORT INC
Common Stock 		M - Exercise 5,000 88,750 5.97
2015-05-19 2015-05-18 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale -50,000 211,032 -19.15 18.09 -904,630 3,818,118
2015-05-19 2015-05-15 4 CAPN Capnia, Inc.
Employee Stock Option 		A - Award 5,000 5,000
2015-05-07 2015-05-05 4 BSX BOSTON SCIENTIFIC CORP
Deferred Stock Units 		A - Award 10,650 10,650
2015-04-07 2015-04-06 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -130 387 -25.15
2015-04-07 2015-04-06 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -750 2,250 -25.00
2015-04-07 2015-04-06 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,761 38,732 -4.35
2015-04-07 2015-04-06 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 130 119,252 0.11 23.26 3,024 2,773,802
2015-04-07 2015-04-06 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 750 119,122 0.63 23.26 17,445 2,770,778
2015-04-07 2015-04-06 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,761 118,372 1.51 5.05 8,893 597,779
2015-03-20 2015-03-18 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -258 517 -33.29
2015-03-20 2015-03-18 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,500 3,000 -33.33
2015-03-20 2015-03-18 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -3,521 40,493 -8.00
2015-03-20 2015-03-18 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 258 116,611 0.22 23.26 6,001 2,712,372
2015-03-20 2015-03-18 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,500 116,353 1.31 23.26 34,890 2,706,371
2015-03-20 2015-03-18 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 3,521 114,853 3.16 5.05 17,781 580,008
2015-03-06 2015-03-06 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 4,000 200,472 2.04 6.57 26,280 1,317,081
2015-02-27 2015-02-25 4 TNXP Tonix Pharmaceuticals Holding Corp.
Restricted Stock Unit 		A - Award 6,000 6,000
2015-02-27 2015-02-25 4 TNXP Tonix Pharmaceuticals Holding Corp.
Stock Option 		A - Award 5,000 5,000
2015-02-09 2015-02-09 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 30,000 196,472 18.02 5.85 175,500 1,149,361
2015-02-04 2015-02-03 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -7,666 0 -100.00
2015-02-04 2015-02-03 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 7,666 137,024 5.93 27.69 212,272 3,794,195
2015-01-28 2015-01-26 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		A - Award 44,000 44,000
2015-01-20 2015-01-16 4 CMRX CHIMERIX INC
Common Stock (Right to Buy) 		M - Exercise -258 775 -24.98
2015-01-20 2015-01-16 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -1,500 4,500 -25.00
2015-01-20 2015-01-16 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -3,521 44,014 -7.41
2015-01-20 2015-01-16 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 258 111,332 0.23 23.26 6,001 2,589,582
2015-01-20 2015-01-16 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 1,500 111,074 1.37 23.26 34,890 2,583,581
2015-01-20 2015-01-16 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 3,521 109,574 3.32 5.05 17,781 553,349
2015-01-13 2015-01-11 4 CAPN Capnia, Inc.
Employee Stock Option 		A - Award 5,000 5,000
2014-12-19 2014-12-18 4 TNXP Tonix Pharmaceuticals Holding Corp.
Series A common stock purchase warrant 		X - Other -30,000 0 -100.00
2014-12-19 2014-12-18 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		X - Other 30,000 166,472 21.98 4.25 127,500 707,506
2014-12-02 2014-12-01 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 261,032 -3.69 12.96 -129,618 3,383,445
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Series A Warrant to Purchase Common Stock 		P - Purchase 253,846 597,232 73.92
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Series B Warrant to Purchase Common Stock 		P - Purchase 253,846 597,232 73.92
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Series A Warrant to Purchase Common Stock 		P - Purchase 44,770 89,540 100.00
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Series B Warrant to Purchase Common Stock 		P - Purchase 44,770 89,540 100.00
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Warrant to Purchase Common Stock 		J - Other 21,928 43,893 99.83
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Warrant to Purchase Common Stock 		J - Other 8,275 21,965 60.45
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Warrant to Purchase Common Stock 		J - Other 13,690 13,690
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Series C Preferred Stock 		C - Conversion -10,416 0 -100.00
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Series C Preferred Stock 		C - Conversion -10,416 0 -100.00
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Series C Preferred Stock 		C - Conversion -48,885 20,832 -70.12
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
2014 Convertible Promissory Notes 		S - Sale -203,705 0 -100.00
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
2010/2012 Convertible Promissory Notes 		S - Sale -555,250 0 -100.00
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
2010/2012 Convertible Promissory Notes 		S - Sale -260,471 0 -100.00
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
2010/2012 Convertible Promissory Notes 		S - Sale -471,192 0 -100.00
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 253,846 632,720 67.00
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 44,770 378,874 13.40
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 114,072 334,104 51.84
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 53,512 220,032 32.14
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Common Stock 		P - Purchase 96,803 166,520 138.85
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Common Stock 		C - Conversion 10,416 69,717 17.56
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Common Stock 		C - Conversion 10,416 69,717 17.56
2014-11-20 2014-11-18 4 CAPN Capnia, Inc.
Common Stock 		C - Conversion 48,885 48,885
2014-11-14 2014-11-12 4 CAPN Capnia, Inc.
Employee Stock Option 		A - Award 7,000 56,772 14.06
2014-11-14 2014-11-12 4 CAPN Capnia, Inc.
Employee Stock Option 		A - Award 49,772 56,772 711.03
2014-11-12 3 CAPN Capnia, Inc.
No securities beneficially owned 		0
2014-11-06 2014-11-05 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 10,000 106,053 10.41 29.00 290,000 3,075,537
2014-11-06 2014-11-04 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -517 1,033 -33.35
2014-11-06 2014-11-04 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -3,000 6,000 -33.33
2014-11-06 2014-11-04 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -5,282 47,535 -10.00
2014-11-06 2014-11-04 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 517 96,053 0.54 23.26 12,025 2,234,193
2014-11-06 2014-11-04 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 3,000 95,536 3.24 23.26 69,780 2,222,167
2014-11-06 2014-11-04 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 5,282 92,536 6.05 5.05 26,674 467,307
2014-11-04 2014-11-03 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 271,032 -3.56 13.30 -132,998 3,604,671
2014-11-03 2014-10-31 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		A - Award 13,177 281,032 4.92
2014-10-31 2014-10-29 4 TNXP Tonix Pharmaceuticals Holding Corp.
Stock Option 		A - Award 5,000 5,000
2014-10-29 2014-10-27 4 CELG CELGENE CORP /DE/
Common Stock 		S - Sale -100,000 129,358 -43.60 102.85 -10,284,630 13,303,992
2014-10-09 2014-10-08 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 267,855 -3.60 12.06 -120,600 3,230,331
2014-09-29 2014-09-29 4 TNXP Tonix Pharmaceuticals Holding Corp.
Series A common stock purchase warrant 		X - Other -10,000 30,000 -25.00
2014-09-29 2014-09-29 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		X - Other 10,000 136,472 7.91 4.25 42,500 580,006
2014-09-08 2014-09-05 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 10,000 87,254 12.94 23.19 231,872 2,023,176
2014-09-03 2014-09-02 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 277,855 -3.47 12.60 -125,992 3,500,751
2014-09-03 2014-09-03 4 Kin Kindred Biosciences, Inc.
Common Stock 		P - Purchase 10,000 52,500 23.53 10.55 105,493 553,838
2014-08-27 2014-08-26 4 TNXP Tonix Pharmaceuticals Holding Corp.
Series A common stock purchase warrant 		X - Other -7,059 40,000 -15.00
2014-08-27 2014-08-26 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		X - Other 7,059 126,472 5.91 4.25 30,001 537,506
2014-08-27 2014-08-26 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -8,803 52,817 -14.29
2014-08-27 2014-08-26 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 8,803 77,254 12.86 5.05 44,455 390,133
2014-08-06 2014-08-01 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		M - Exercise -2,500 22,500 -10.00
2014-08-06 2014-08-01 4 KIN Kindred Biosciences, Inc.
Common Stock 		M - Exercise 2,500 42,500 6.25 0.32 800 13,600
2014-08-05 2014-08-01 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 287,855 -3.36 12.58 -125,817 3,621,705
2014-07-28 2014-07-24 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -5,000 7,666 -39.48
2014-07-28 2014-07-24 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 5,000 229,358 2.23 27.69 138,450 6,350,923
2014-07-28 2014-03-25 4 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -196 2,574 -7.08
2014-07-28 2014-03-25 4 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -196 2,574 -7.08
2014-07-28 2014-03-03 4 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -2,210 2,770 -44.38
2014-07-28 2014-03-03 4 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -2,210 2,770 -44.38
2014-07-28 2014-02-18 4 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -1,020 4,980 -17.00
2014-07-28 2014-02-18 4 CELG CELGENE CORP /DE/
Common Stock 		G - Gift -1,020 4,980 -17.00
2014-07-02 2014-07-01 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 297,855 -3.25 12.95 -129,468 3,856,269
2014-07-02 2014-07-01 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		A - Award 2,200 2,200
2014-07-02 2014-07-01 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		A - Award 20,700 20,700
2014-06-24 2014-06-20 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		A - Award 1,550 1,550
2014-06-24 2014-06-20 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		A - Award 9,000 9,000
2014-06-19 2014-06-17 4 TNXP Tonix Pharmaceuticals Holding Corp.
Stock Option 		A - Award 5,000 5,000
2014-06-17 2014-06-17 4 XNPT XENOPORT INC
Non-employee director stock unit 		A - Award 5,000 5,000
2014-06-16 2016-06-16 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 2,055 113,892 1.84
2014-06-16 2014-06-16 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -2,055 0 -100.00
2014-06-16 2014-06-15 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -3,100 0 -100.00
2014-06-16 2014-06-15 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 3,100 111,837 2.85
2014-06-16 2014-06-13 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -1,033 1,034 -49.98
2014-06-16 2014-06-13 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 1,033 108,737 0.96
2014-06-16 2014-06-12 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -1,033 2,067 -33.32
2014-06-16 2014-06-12 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 1,033 107,704 0.97
2014-06-11 2014-06-11 4 XNPT XENOPORT INC
Non-employee director stock option 		A - Award 15,000 15,000
2014-06-03 2014-06-02 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 307,855 -3.15 12.88 -128,790 3,964,865
2014-05-28 2014-05-27 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 10,000 68,451 17.11 14.22 142,200 973,373
2014-05-27 2014-05-23 4 XNPT XENOPORT INC
Common Stock 		P - Purchase 30,000 83,750 55.81 3.73 111,978 312,605
2014-05-23 2014-05-09 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		M - Exercise -2,500 25,000 -9.09
2014-05-23 2014-05-09 4 KIN Kindred Biosciences, Inc.
Common Stock 		M - Exercise 2,500 40,000 6.67 0.32 800 12,800
2014-05-16 2014-05-14 4 XNPT XENOPORT INC
Non-employee direct stock unit 		M - Exercise -5,000 0 -100.00
2014-05-16 2014-05-14 4 XNPT XENOPORT INC
Common Stock 		M - Exercise 5,000 53,750 10.26
2014-05-02 2014-05-01 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 317,855 -3.05 12.58 -125,836 3,999,760
2014-04-08 2014-04-07 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -6,000 6,333 -48.65
2014-04-08 2014-04-07 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 6,000 106,671 5.96 55.38 332,280 5,907,440
2014-04-02 2014-04-01 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 327,855 -2.96 13.55 -135,527 4,443,320
2014-04-01 2014-04-01 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -7,047 61,620 -10.26
2014-04-01 2014-04-01 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 7,047 58,451 13.71 5.05 35,587 295,178
2014-03-05 2014-03-03 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 337,855 -2.87 12.98 -129,755 4,383,838
2014-02-26 2014-02-11 4 TNXP Tonix Pharmaceuticals Holding Corp.
Stock Option 		A - Award 5,500 5,500
2014-02-07 2014-02-06 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale -17,104 347,855 -4.69 12.80 -218,935 4,452,614
2014-02-06 2014-02-05 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -6,875 0 -100.00
2014-02-06 2014-02-05 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -4,625 0 -100.00
2014-02-06 2014-02-05 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -2,000 0 -100.00
2014-02-06 2014-02-05 4 CELG CELGENE CORP /DE/
Common Stock 		S - Sale -13,500 100,671 -11.82 151.87 -2,050,284 15,289,197
2014-02-06 2014-02-05 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 6,875 114,171 6.41 60.02 412,638 6,852,543
2014-02-06 2014-02-05 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 4,625 107,296 4.50 67.75 313,344 7,269,304
2014-02-06 2014-02-05 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 2,000 102,671 1.99 59.89 119,780 6,148,966
2014-02-06 2014-02-04 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -7,000 6,875 -50.45
2014-02-06 2014-02-04 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 7,000 100,671 7.47 60.02 420,140 6,042,273
2014-02-05 2014-02-05 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		M - Exercise -12,500 27,500 -31.25
2014-02-05 2014-02-05 4 KIN Kindred Biosciences, Inc.
Common Stock 		M - Exercise 12,500 37,500 50.00 0.32 4,000 12,000
2014-02-05 2014-02-03 4 KIN Kindred Biosciences, Inc.
Stock Option (right to buy) 		A - Award 37,000 37,000
2014-02-04 2014-02-03 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 364,959 -2.67 13.19 -131,884 4,813,225
2014-01-09 2014-01-07 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -2,000 2,000 -50.00
2014-01-09 2014-01-07 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 2,000 93,671 2.18 59.89 119,780 5,609,956
2014-01-08 2014-01-06 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 374,959 -2.60 12.50 -125,000 4,686,988
2013-12-30 2013-12-26 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale X -10,000 384,959 -2.53 12.06 -120,600 4,642,606
2013-12-13 2013-12-12 4 KIN Kindred Biosciences, Inc.
Common Stock 		P - Purchase 25,000 25,000 7.00 175,000 175,000
2013-12-13 2013-12-13 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 5,000 51,404 10.77 13.90 69,500 714,516
2013-11-25 2013-11-25 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 8,000 46,404 20.83 15.20 121,600 705,341
2013-11-20 2013-11-19 4 CMRX CHIMERIX INC
Stock Option (Right to Buy) 		M - Exercise -15,840 68,667 -18.74
2013-11-20 2013-11-19 4 CMRX CHIMERIX INC
Common Stock 		M - Exercise 15,840 38,404 70.20 5.05 79,992 193,940
2013-11-20 2013-11-19 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 7,500 22,564 49.79 15.25 114,375 344,101
2013-11-12 2013-11-08 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale -20,445 0 -100.00 11.73 -239,857
2013-11-12 2013-11-08 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		S - Sale -115,200 394,959 -22.58 11.73 -1,351,503 4,633,580
2013-10-28 2013-10-24 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -6,000 4,000 -60.00
2013-10-28 2013-10-24 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 6,000 91,671 7.00 59.89 359,340 5,490,176
2013-09-30 2013-09-27 4 XNPT XENOPORT INC
Non-employee director stock option 		M - Exercise -18,750 11,250 -62.50
2013-09-30 2013-09-27 4 XNPT XENOPORT INC
Common stock 		M - Exercise 18,750 48,750 62.50 5.79 108,562 282,262
2013-09-03 2013-08-30 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 64 15,064 0.43 15.75 1,008 237,258
2013-09-03 2013-08-30 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 786 15,000 5.53 15.80 12,419 237,000
2013-09-03 2013-08-29 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 1,714 14,214 13.71 15.80 27,081 224,581
2013-09-03 2013-08-29 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 2,500 12,500 25.00 15.85 39,625 198,125
2013-08-27 2013-08-26 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 2,000 10,000 25.00 16.80 33,600 168,000
2013-08-27 2013-08-26 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 2,000 8,000 33.33 17.30 34,600 138,400
2013-08-27 2013-08-26 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 1,960 6,000 48.51 17.50 34,300 105,000
2013-08-20 2013-08-20 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 40 4,040 1.00 17.50 700 70,700
2013-08-20 2013-08-19 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 2,000 4,000 100.00 17.50 35,000 70,000
2013-08-20 2013-08-16 4 CMRX CHIMERIX INC
Common Stock 		P - Purchase 2,000 2,000 17.45 34,900 34,900
2013-08-15 2013-08-14 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -4,625 0 -100.00
2013-08-15 2013-08-14 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 4,625 85,671 5.71 54.35 251,369 4,656,219
2013-08-15 2013-08-14 4 TNXP Tonix Pharmaceuticals Holding Corp.
Series A common stock purchase warrant 		P - Purchase 47,059 47,059
2013-08-15 2013-08-14 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, $0.001 par value 		P - Purchase 47,059 119,713 64.77
2013-06-17 2013-06-13 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -1,033 2,067 -33.32
2013-06-17 2013-06-13 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 1,033 81,046 1.29
2013-06-14 2013-06-12 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		A - Award 3,100 3,100
2013-06-14 2013-06-12 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		A - Award 9,300 9,300
2013-06-07 2013-06-05 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -15,000 10,000 -60.00
2013-06-07 2013-06-05 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 15,000 80,013 23.07 59.89 898,350 4,791,979
2013-05-30 2013-05-29 4 VVUS VIVUS INC
Common Stock 		P - Purchase 15,000 81,125 22.68 14.68 220,206 1,190,947
2013-05-30 2013-05-29 4 CELG CELGENE CORP /DE/
Common Stock 		P - Purchase 400 65,013 0.62 123.73 49,493 8,044,189
2013-05-30 2013-05-29 4 CELG CELGENE CORP /DE/
Common Stock 		P - Purchase 600 64,613 0.94 123.72 74,232 7,993,920
2013-05-23 2013-05-22 4 XNPT XENOPORT INC
Common Stock 		P - Purchase 20,000 30,000 200.00 5.49 109,800 164,700
2013-05-16 2013-05-14 4 XNPT XENOPORT INC
Non-employee director stock unit 		A - Award 5,000 5,000
2013-05-16 2013-05-14 4 XNPT XENOPORT INC
Non-employee director stock option 		A - Award 15,000 15,000
2013-05-08 2013-05-07 4 BSX BOSTON SCIENTIFIC CORP
Phantom Stock 		A - Award 22,756 130,098 21.20
2013-05-08 2013-05-06 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		P - Purchase 30,000 509,304 6.26 7.76 232,800 3,952,199
2013-04-29 2013-04-26 4 TNXP Tonix Pharmaceuticals Holding Corp.
Warrants 		C - Conversion -166,667 216,667 -43.48
2013-04-29 2013-04-26 4 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock 		C - Conversion 166,667 1,447,079 13.02 0.40 66,667 578,832
2013-02-19 2013-02-12 4 TNXP Tonix Pharmaceuticals Holding Corp.
Stock Option 		A - Award 210,000 0 -100.00
2013-01-29 2013-01-25 4 VVUS VIVUS INC
Common Stock 		A - Award 21,125 66,125 46.94
2013-01-14 3 TNXP Tonix Pharmaceuticals Holding Corp.
Common Stock, Par Value $0.001 		1,280,412
2012-08-21 2012-08-20 4 VVUS VIVUS INC
Common Stock 		P - Purchase 5,000 45,000 12.50 20.75 103,750 933,750
2012-08-13 2012-08-10 4 VVUS VIVUS INC
Common Stock 		P - Purchase 5,000 40,000 14.29 21.50 107,500 860,000
2012-08-13 2012-08-09 4 VVUS VIVUS INC
Common Stock 		P - Purchase 15,000 35,000 75.00 21.83 327,399 763,931
2012-08-09 2012-08-09 4 XNPT XENOPORT INC
Common Stock 		P - Purchase 10,000 10,000 8.50 84,983 84,983
2012-08-08 2012-08-06 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		P - Purchase 32,000 479,304 7.15 5.29 169,280 2,535,518
2012-06-19 2012-06-17 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		M - Exercise -685 0 -100.00
2012-06-19 2012-06-17 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 685 64,013 1.08
2012-06-18 2012-06-15 4 XNPT XENOPORT INC
Non-employee director stock option 		A - Award 30,000 30,000
2012-06-15 2012-06-13 4 CELG CELGENE CORP /DE/
Restricted Stock Unit 		A - Award 3,100 3,100
2012-06-15 2012-06-13 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		A - Award 9,300 9,300
2012-06-07 2012-06-06 4 MAXY MAXYGEN INC
Common Stock 		A - Award 10,000 62,964 18.88
2012-05-10 2012-05-08 4 BSX BOSTON SCIENTIFIC CORP
Phantom Stock 		A - Award 24,116 107,342 28.98
2012-04-30 2012-04-27 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -12,333 0 -100.00
2012-04-30 2012-04-27 4 CELG CELGENE CORP /DE/
Stock Option (right to buy) 		M - Exercise -4,625 0 -100.00
2012-04-30 2012-04-27 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 12,333 63,328 24.18 44.94 554,245 2,845,960
2012-04-30 2012-04-27 4 CELG CELGENE CORP /DE/
Common Stock 		M - Exercise 4,625 50,995 9.97 49.93 230,926 2,546,180
2012-04-27 2012-04-25 4 VVUS VIVUS INC
Common Stock 		A - Award 20,000 20,000
2012-02-27 2012-02-23 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		P - Purchase 10,000 447,304 2.29 5.91 59,100 2,643,567
2012-02-23 2012-02-22 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		P - Purchase 10,000 437,304 2.34 5.93 59,300 2,593,213
2012-02-22 2012-02-21 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		P - Purchase 20,000 427,304 4.91 6.12 122,400 2,615,100
2011-02-09 2011-02-07 4 BSX BOSTON SCIENTIFIC CORP
Common Stock 		P - Purchase 50,000 131,004 61.73 6.94 346,990 909,142
2009-05-07 2009-05-05 4 BSX BOSTON SCIENTIFIC CORP
Phantom Stock 		A - Award 14,501 42,521 51.75
2007-08-23 3 CELG CELGENE CORP /DE/
Common Stock 		10,000
P
Open market or private purchase of non-derivative or derivative security
S
Open market or private sale of non-derivative or derivative security
A
Grant, award, or other acquisition of securities from the company (such as an option)
C
Conversion of derivative
D
Sale or transfer of securities back to the company
F
Payment of exercise price or tax liability using portion of securities received from the company
G
Gift of securities by or to the insider
K
Equity swaps and similar hedging transactions
M
Exercise or conversion of derivative security received from the company (such as an option)
V
A transaction voluntarily reported on Form 4
J
Other (accompanied by a footnote describing the transaction)