Introduction

This page provides a comprehensive analysis of the known insider trading history of James C Hamilton. Insiders are officers, directors, or significant investors in a company. It is illegal for insiders to make trades in their companies based on specific, non-public information. This does not mean it is illegal for them to make any trades in their own companies. However, they must report all trades to the SEC via a Form 4. Despite these restrictions, academic research suggests that insiders - in general - tend to outperform the market in their own companies.

Average Trade Profitability

The average trade profitability is the average return of all the open market purchases made by the insider in the last three years. To calculate this, we examine every open-market, unplanned purchase made by the insider, excluding all trades that were marked as part of a 10b5-1 trading plan. We then calculate the average performance of those trades over 3, 6, and 12 months, averaging each of those durations to generate a final performance metric for each trade. Finally, we average all of the performance metrics to calculate a performance metric for the insider. This list only includes insiders that have made at least three trades in the last two years.

If this insiders trade profitability is "N/A", then the insider either has not made any open-market purchases in the last three years, or the trades they’ve made are too recent to calculate a reliable performance metric.

Update Frequency: Daily

See the list of most profitable insider traders.

Companies with Reported Insider Positions

The SEC filings indicate James C Hamilton has reported holdings or trades in the following companies:

Security Title Latest Reported Holdings
US:ARWR / Arrowhead Pharmaceuticals, Inc. Chief Medical Officer 247,122
How to Interpret the Charts

The following charts show the stock performance of securities subsequent to each open-market, non-planned trade made by James C Hamilton. Non-planned trade are trades that were not made as part of a 10b5-1 trading plan. The stock performance is charted as cumulative percent change in share price. For example, if an insider trade was made on January 1, 2019, the chart will show the daily percent change of the security to the present day. If the share price were to go from $10 to $15 during this time, the cumulative percent change in share price would be 50%. A change in price from $10 to $20 would be 100%, and a change in price of $10 to $5 would be -50%.

Ultimately, we are trying to determine how closely the insider’s trades correlate to excess returns (positive or negative) in the share price in order to see if the insider is timing their trades to profit from insider information. Consider the situation where an insider was doing this. In this situation, we would expect either (a) positive returns after purchases, or (b) negative returns after sales. In the case of (a), the PURCHASE chart would show a series of upwardly sloping curves, indicating positive returns after each purchase transaction. In the case of (b), the SALE chart would show a series of downward sloping curves, indicating negative returns after each sale transaction.

However, this alone is not enough to draw conclusions. If, for example, the share price of the company was in a non-cyclical climb over many years, then we would expect all the post-purchase plots to be upwardly sloping. Likewise, non-cyclical declines over many years would result in downward sloping post-trade plots. Neither of these charts would suggest insider trading activity.

The strongest indicator would be a situation where the share price was extremely cyclical, and there were both positive signals in the PURCHASE chart and negative plots on the SALE chart. This situation would be highly suggestive of an insider that was timing trades to their financial advantage.

Insider Trading History

This table shows the complete list of insider trades made by James C Hamilton as disclosed to the Securities Exchange Commission (SEC).

File Date Tran Date Form Ticker Security Code 10b5-1 Shares Remaining Shares Percent
Change
Share
Price
Tran
Value
Remaining
Value
2025-09-04 2025-09-02 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -15,000 247,122 -5.72 25.00 -375,000 6,178,050
2025-08-15 2025-08-15 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -9,389 262,122 -3.46 20.00 -187,780 5,242,440
2025-08-15 2025-08-13 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -611 271,511 -0.22 20.00 -12,220 5,430,220
2025-01-07 2025-01-06 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -10,971 272,122 -3.88 20.11 -220,627 5,472,373
2025-01-07 2025-01-06 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -21,758 283,093 -7.14 19.68 -428,197 5,571,270
2025-01-07 2025-01-04 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
A - Award 100,000 304,851 48.82
2024-04-03 2024-04-01 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale -6,000 204,851 -2.85 28.03 -168,180 5,741,974
2024-01-17 2024-01-12 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -3,702 210,851 -1.73 37.37 -138,344 7,879,502
2024-01-17 2024-01-12 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -4,238 214,553 -1.94 36.47 -154,560 7,824,748
2024-01-05 2024-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -10,000 218,791 -4.37 35.00 -350,000 7,657,685
2024-01-05 2024-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -12,343 228,791 -5.12 35.65 -440,028 8,156,399
2024-01-05 2024-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -8,000 241,134 -3.21 34.94 -279,520 8,425,222
2024-01-05 2024-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -1,800 249,134 -0.72 34.00 -61,200 8,470,556
2024-01-05 2024-01-04 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
A - Award 75,000 250,934 42.63
2024-01-05 2024-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -500 175,934 -0.28 33.30 -16,650 5,858,602
2024-01-05 2024-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -2,300 176,434 -1.29 32.52 -74,796 5,737,634
2024-01-05 2024-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -3,500 178,734 -1.92 31.81 -111,335 5,685,529
2023-07-05 2023-06-30 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale -3,000 188,484 -1.57 35.53 -106,590 6,696,837
2023-01-06 2023-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -6,573 191,484 -3.32 37.40 -245,830 7,161,502
2023-01-06 2023-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -7,230 198,057 -3.52 37.40 -270,402 7,407,332
2023-01-05 2023-01-04 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
A - Award 60,000 205,287 41.30
2023-01-05 2023-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -247 145,287 -0.17 40.52 -10,008 5,887,029
2023-01-05 2023-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -300 145,534 -0.21 39.56 -11,868 5,757,325
2023-01-05 2023-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -3,682 145,834 -2.46 38.52 -141,831 5,617,526
2023-01-05 2023-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -1,642 149,516 -1.09 37.49 -61,559 5,605,355
2023-01-05 2023-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -136 151,158 -0.09 40.54 -5,513 6,127,945
2023-01-05 2023-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -300 151,294 -0.20 39.74 -11,922 6,012,424
2023-01-05 2023-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -2,837 151,594 -1.84 38.53 -109,310 5,840,917
2023-01-05 2023-01-03 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -1,194 154,431 -0.77 37.46 -44,727 5,784,985
2022-01-06 2022-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -60 155,625 -0.04 64.35 -3,861 10,014,469
2022-01-06 2022-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -700 155,685 -0.45 63.68 -44,576 9,914,021
2022-01-06 2022-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -1,100 156,385 -0.70 62.64 -68,904 9,795,956
2022-01-06 2022-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -2,100 157,485 -1.32 61.84 -129,864 9,738,872
2022-01-06 2022-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -2,290 159,585 -1.41 60.51 -138,568 9,656,488
2022-01-06 2022-01-04 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -500 161,875 -0.31 69.38 -34,690 11,230,888
2022-01-06 2022-01-04 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -649 162,375 -0.40 68.12 -44,210 11,060,985
2022-01-06 2022-01-04 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -802 163,024 -0.49 67.39 -54,047 10,986,187
2022-01-06 2022-01-04 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -7,469 163,826 -4.36 65.59 -489,892 10,745,347
2022-01-06 2022-01-04 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -9,955 171,295 -5.49 64.89 -645,980 11,115,333
2022-01-04 2022-01-01 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
A - Award 55,000 181,250 43.56
2021-01-15 2021-01-14 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale -3,814 126,250 -2.93 81.82 -312,061 10,329,775
2021-01-15 2021-01-14 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale -6,186 130,064 -4.54 80.97 -500,880 10,531,282
2021-01-07 2021-01-06 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -14,708 136,250 -9.74 72.67 -1,068,830 9,901,288
2021-01-07 2021-01-06 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -3,967 150,958 -2.56 72.05 -285,822 10,876,524
2021-01-07 2021-01-06 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -700 154,925 -0.45 70.89 -49,623 10,982,633
2021-01-07 2021-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -1,925 155,625 -1.22 73.93 -142,315 11,505,356
2021-01-07 2021-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -10,350 157,550 -6.16 72.91 -754,618 11,486,970
2021-01-07 2021-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -3,300 167,900 -1.93 72.19 -238,227 12,120,701
2021-01-07 2021-01-05 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
S - Sale X -3,800 171,200 -2.17 71.09 -270,142 12,170,608
2021-01-05 2021-01-01 4 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
A - Award 50,000 175,000 40.00
2020-11-02 3 ARWR ARROWHEAD PHARMACEUTICALS, INC.
Common Stock
125,000
P
Open market or private purchase of non-derivative or derivative security
S
Open market or private sale of non-derivative or derivative security
A
Grant, award, or other acquisition of securities from the company (such as an option)
C
Conversion of derivative
D
Sale or transfer of securities back to the company
F
Payment of exercise price or tax liability using portion of securities received from the company
G
Gift of securities by or to the insider
K
Equity swaps and similar hedging transactions
M
Exercise or conversion of derivative security received from the company (such as an option)
V
A transaction voluntarily reported on Form 4
J
Other (accompanied by a footnote describing the transaction)