Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

Introduction

This page provides a comprehensive analysis of the known insider trading history of C Frank Bennett. Insiders are officers, directors, or significant investors in a company. It is illegal for insiders to make trades in their companies based on specific, non-public information. This does not mean it is illegal for them to make any trades in their own companies. However, they must report all trades to the SEC via a Form 4. Despite these restrictions, academic research suggests that insiders - in general - tend to outperform the market in their own companies.

Average Trade Profitability

The average trade profitability is the average return of all the open market purchases made by the insider in the last three years. To calculate this, we examine every open-market, unplanned purchase made by the insider, excluding all trades that were marked as part of a 10b5-1 trading plan. We then calculate the average performance of those trades over 3, 6, and 12 months, averaging each of those durations to generate a final performance metric for each trade. Finally, we average all of the performance metrics to calculate a performance metric for the insider. This list only includes insiders that have made at least three trades in the last two years.

If this insiders trade profitability is "N/A", then the insider either has not made any open-market purchases in the last three years, or the trades they’ve made are too recent to calculate a reliable performance metric.

Update Frequency: Daily

See the list of most profitable insider traders.

Companies with Reported Insider Positions

The SEC filings indicate C Frank Bennett has reported holdings or trades in the following companies:

Security Title Latest Reported Holdings
US:IONS / Ionis Pharmaceuticals, Inc. EVP, Chief Scientific Officer 82,679
How to Interpret the Charts

The following charts show the stock performance of securities subsequent to each open-market, non-planned trade made by C Frank Bennett. Non-planned trade are trades that were not made as part of a 10b5-1 trading plan. The stock performance is charted as cumulative percent change in share price. For example, if an insider trade was made on January 1, 2019, the chart will show the daily percent change of the security to the present day. If the share price were to go from $10 to $15 during this time, the cumulative percent change in share price would be 50%. A change in price from $10 to $20 would be 100%, and a change in price of $10 to $5 would be -50%.

Ultimately, we are trying to determine how closely the insider’s trades correlate to excess returns (positive or negative) in the share price in order to see if the insider is timing their trades to profit from insider information. Consider the situation where an insider was doing this. In this situation, we would expect either (a) positive returns after purchases, or (b) negative returns after sales. In the case of (a), the PURCHASE chart would show a series of upwardly sloping curves, indicating positive returns after each purchase transaction. In the case of (b), the SALE chart would show a series of downward sloping curves, indicating negative returns after each sale transaction.

However, this alone is not enough to draw conclusions. If, for example, the share price of the company was in a non-cyclical climb over many years, then we would expect all the post-purchase plots to be upwardly sloping. Likewise, non-cyclical declines over many years would result in downward sloping post-trade plots. Neither of these charts would suggest insider trading activity.

The strongest indicator would be a situation where the share price was extremely cyclical, and there were both positive signals in the PURCHASE chart and negative plots on the SALE chart. This situation would be highly suggestive of an insider that was timing trades to their financial advantage.

Insider Purchases IONS / Ionis Pharmaceuticals, Inc. - Short Term Profit Analysis

In this section, we analyze the profitability of every unplanned, open-market insider purchase made in IONS / Ionis Pharmaceuticals, Inc.. This analysis helps to understand if the insider consistently generates abnormal returns, and is worth following. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market purchases that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Max
Price at
Max
Max
Profit ($)
Max Return (%)
There are no known unplanned open-market trades for this insider and security combination

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Insider Sales IONS / Ionis Pharmaceuticals, Inc. - Short Term Loss Analysis

In this section, we analyze the short-term loss avoidance of every unplanned, open-market insider sale made in IONS / Ionis Pharmaceuticals, Inc.. A consistent pattern of loss avoidance may suggest that future sale transactions may predict declines in price. This analysis is for one-year following each trade, and the results are theoretical.

The following table shows the most recent open market sales that were not part of an automatic trading plan.

Trade Date Ticker Insider Reported
Shares
Reported
Price
Adjusted
Shares
Adjusted
Price
Cost Basis Days to
Min
Price at
Min
Max Loss
Avoided ($)
Max Loss
Avoided (%)
2025-01-31 IONS BENNETT C FRANK 1,327 32.4636 1,327 32.4636 43,079 67 25.5100 -9,227 -21.42
2025-01-16 IONS BENNETT C FRANK 6,752 32.8960 6,752 32.8960 222,114
2024-02-02 IONS BENNETT C FRANK 1,853 49.5156 1,853 49.5156 91,752
2024-02-02 IONS BENNETT C FRANK 1,885 49.5156 1,885 49.5156 93,337
2024-01-17 IONS BENNETT C FRANK 6,745 50.4170 6,745 50.4170 340,063
2023-12-21 IONS BENNETT C FRANK 16,113 49.2901 16,113 49.2901 794,211
2023-12-20 IONS BENNETT C FRANK 6,500 49.6374 6,500 49.6374 322,643
2023-12-14 IONS BENNETT C FRANK 14,002 49.2133 14,002 49.2133 689,085
2023-12-14 IONS BENNETT C FRANK 8,610 50.1870 8,610 50.1870 432,110
2023-02-06 IONS BENNETT C FRANK 1,813 40.5738 1,813 40.5738 73,560
2023-01-18 IONS BENNETT C FRANK 6,978 38.8874 6,978 38.8874 271,356
2018-01-16 IONS BENNETT C FRANK 2,696 51.7600 2,696 51.7600 139,545
2017-01-17 IONS BENNETT C FRANK 553 46.2900 553 46.2900 25,598
2017-01-17 IONS BENNETT C FRANK 733 46.2900 733 46.2900 33,931
2017-01-17 IONS BENNETT C FRANK 512 46.2910 512 46.2910 23,701
2017-01-17 IONS BENNETT C FRANK 623 46.2900 623 46.2900 28,839
2016-01-19 IONS BENNETT C FRANK 277 41.4579 277 41.4579 11,484
2016-01-19 IONS BENNETT C FRANK 564 41.4588 564 41.4588 23,383
2016-01-19 IONS BENNETT C FRANK 747 41.4555 747 41.4555 30,967
2016-01-19 IONS BENNETT C FRANK 522 41.4562 522 41.4562 21,640
2015-01-16 ISIS BENNETT C FRANK 265 67.9640 265 67.9640 18,010
2015-01-16 ISIS BENNETT C FRANK 539 67.9640 539 67.9640 36,633
2015-01-16 ISIS BENNETT C FRANK 714 67.9640 714 67.9640 48,526
2014-01-16 ISIS BENNETT C FRANK 539 47.0811 539 47.0811 25,377
2014-01-16 ISIS BENNETT C FRANK 265 47.0810 265 47.0810 12,476
2013-01-16 ISIS BENNETT C FRANK 309 14.0000 309 14.0000 4,326

Adjusted Price is the split-adjusted price. Adjusted Shares is the split-adjusted shares.

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Insider Trading History

This table shows the complete list of insider trades made by C Frank Bennett as disclosed to the Securities Exchange Commission (SEC).

File Date Tran Date Form Ticker Security Code 10b5-1 Shares Remaining Shares Percent
Change
Share
Price
Tran
Value
Remaining
Value
2025-09-09 2025-09-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,000 82,679 -6.77 59.60 -357,581 4,927,404
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X -12,891 88,679 -12.69 61.50 -792,796 5,453,758
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -33,909 101,570 -25.03 60.62 -2,055,564 6,157,173
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 46,800 135,479 52.77 53.77 2,516,436 7,284,706
2025-09-04 2025-09-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,000 88,679 -5.34 49.14 -245,700 4,357,686
2025-09-03 2025-08-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 213 93,679 0.23 27.71 5,902 2,595,845
2025-08-20 2025-08-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10,000 93,466 -9.67 43.98 -439,776 4,110,410
2025-08-20 2025-08-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 10,000 103,466 10.70 32.60 326,000 3,372,992
2025-03-04 2025-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 320 93,466 0.34 28.21 9,028 2,636,816
2025-02-03 2025-01-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,327 93,146 -1.40 32.46 -43,079 3,023,854
2025-02-03 2025-01-30 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
A - Award 3,607 94,473 3.97
2025-01-17 2025-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -6,752 90,866 -6.92 32.90 -222,114 2,989,128
2025-01-17 2025-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 18,011 97,618 22.62
2024-09-04 2024-02-02 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,885 79,047 -2.33 49.52 -93,337 3,914,060
2024-09-04 2024-08-30 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 177 79,607 0.22 38.64 6,839 3,076,094
2024-03-04 2024-02-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 383 79,462 0.48 34.42 13,185 2,735,479
2024-02-02 2024-02-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,853 79,079 -2.29 49.52 -91,752 3,915,644
2024-02-02 2024-02-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
A - Award 3,609 80,932 4.67
2024-01-18 2024-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -6,745 77,323 -8.02 50.42 -340,063 3,898,394
2024-01-18 2024-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 18,314 84,068 27.85
2023-12-22 2023-12-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -16,113 65,754 -19.68 49.29 -794,211 3,241,021
2023-12-22 2023-12-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 16,113 81,867 24.50 47.34 762,789 3,875,584
2023-12-22 2023-12-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -6,500 65,754 -9.00 49.64 -322,643 3,263,858
2023-12-22 2023-12-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 6,500 72,254 9.89 47.34 307,710 3,420,504
2023-12-18 2023-12-14 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -8,610 65,754 -11.58 50.19 -432,110 3,299,996
2023-12-18 2023-12-14 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 8,610 74,364 13.09 47.34 407,597 3,520,392
2023-12-18 2023-12-14 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -14,002 65,754 -17.56 49.21 -689,085 3,235,971
2023-12-18 2023-12-14 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 14,002 79,756 21.29 47.34 662,855 3,775,649
2023-09-29 2023-09-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,460 65,754 -6.35 46.50 -207,390 3,057,561
2023-09-05 2023-08-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 180 70,214 0.26 30.56 5,500 2,145,564
2023-03-02 2023-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 383 70,034 0.55 30.52 11,687 2,137,088
2023-02-07 2023-02-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,813 69,651 -2.54 40.57 -73,560 2,826,006
2023-02-07 2023-02-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
A - Award 3,609 71,464 5.32
2023-01-19 2023-01-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -6,978 67,855 -9.32 38.89 -271,356 2,638,705
2023-01-19 2023-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 19,417 74,833 35.04
2022-09-01 2022-08-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 183 55,416 0.33 28.97 5,301 1,605,291
2022-03-02 2022-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 346 55,233 0.63 28.37 9,817 1,567,126
2022-01-20 2022-01-18 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
M - Exercise -18,842 24,444 -43.53
2022-01-20 2022-01-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -6,726 54,887 -10.92 30.12 -202,587 1,653,196
2022-01-20 2022-01-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 18,842 61,613 44.05
2022-01-19 2022-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
A - Award 14,435 43,286 50.03
2022-01-19 2022-01-15 4 IONS IONIS PHARMACEUTICALS INC
Performance Restricted Stock Units
A - Award 10,826 10,826
2022-01-05 2022-01-03 4 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
A - Award 28,869 28,869
2021-09-02 2021-08-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 151 42,771 0.35 33.80 5,103 1,445,489
2021-03-02 2021-02-26 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 112 42,620 0.26 44.54 4,988 1,898,295
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -15,520 29,641 -34.37
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 20,822 20,822
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -5,488 42,508 -11.43 61.28 -336,305 2,604,890
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 15,520 47,996 47.79
2021-01-06 2021-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 46,850 46,850
2020-12-08 2020-12-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -7,947 0 -100.00
2020-12-08 2020-12-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -7,947 32,476 -19.66 51.04 -405,615 1,657,575
2020-12-08 2020-12-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 7,947 40,423 24.47 39.87 316,847 1,611,665
2020-12-04 2020-12-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -7,053 7,947 -47.02
2020-12-04 2020-12-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -7,053 32,476 -17.84 51.32 -361,960 1,666,668
2020-12-04 2020-12-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 7,053 39,529 21.72 39.87 281,203 1,576,021
2020-11-05 2020-11-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -15,000 15,000 -50.00
2020-11-05 2020-11-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15,000 32,476 -31.59 46.77 -701,600 1,519,010
2020-11-05 2020-11-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15,000 47,476 46.19 39.87 598,050 1,892,868
2020-09-02 2020-08-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 112 32,476 0.35 44.46 4,979 1,443,721
2020-06-29 2020-06-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15,000 32,364 -31.67 59.77 -896,505 1,934,299
2020-06-29 2020-06-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15,000 47,364 46.35 39.87 598,050 1,888,403
2020-03-03 2020-02-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 169 32,364 0.52 43.16 7,295 1,396,927
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -11,711 23,549 -33.21
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 21,612 21,612
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -4,162 32,195 -11.45 62.06 -258,294 1,998,022
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 11,711 36,357 47.52
2020-01-03 2020-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 48,626 48,626
2019-07-02 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 118 24,646 0.48 45.70 5,393 1,126,433
2019-02-05 2019-02-01 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 9,013 0 -100.00
2019-02-05 2019-02-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -9,013 24,528 -26.87 58.29 -525,368 1,429,737
2019-02-05 2019-02-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 9,013 33,541 36.75 14.69 132,401 492,717
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -7,822 14,463 -35.10
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 20,797 20,797
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -2,818 24,400 -10.35 58.26 -164,177 1,421,544
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7,822 27,218 40.33
2019-01-03 2019-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 46,800 46,800
2019-01-03 2019-01-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 128 19,524 0.66 36.45 4,665 711,611
2018-11-01 2018-11-01 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 12,500 9,013 -358.47
2018-11-01 2018-11-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12,500 19,396 -39.19 49.54 -619,245 960,870
2018-11-01 2018-11-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 12,500 31,896 64.45 14.69 183,625 468,552
2018-08-09 2018-08-08 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 12,487 21,513 138.34
2018-08-09 2018-08-08 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 13 0 -100.00
2018-08-09 2018-08-08 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12,487 19,396 -39.17 45.00 -561,915 872,820
2018-08-09 2018-08-08 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 12,487 31,883 64.38 14.69 183,434 468,361
2018-08-09 2018-08-08 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -13 19,396 -0.07 45.00 -585 872,820
2018-08-09 2018-08-08 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 13 19,409 0.07 7.25 94 140,715
2018-07-03 2018-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 282 19,396 1.48 35.42 9,988 686,997
2018-05-11 2018-05-11 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 12,500 13 -100.10
2018-05-11 2018-05-11 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12,500 19,114 -39.54 45.00 -562,500 860,130
2018-05-11 2018-05-11 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 12,500 31,614 65.40 7.25 90,625 229,202
2018-02-01 2018-02-01 4/A IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 12,500 12,513 96,153.85
2018-02-01 2018-02-01 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12,500 19,114 -39.54 52.50 -656,260 1,003,500
2018-02-01 2018-02-01 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 12,500 31,614 65.40 7.25 90,625 229,202
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -2,696 19,114 -12.36 51.76 -139,545 989,341
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -6,663 10,148 -39.63
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 12,137 12,137
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 6,663 21,810 43.99
2018-01-02 2018-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 54,619 54,619
2018-01-02 2018-01-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 106 15,147 0.70 42.76 4,532 647,610
2017-10-20 2017-10-18 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -12,250 0 -100.00
2017-10-20 2017-10-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12,250 15,041 -44.89 65.00 -796,250 977,665
2017-10-20 2017-10-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 12,250 27,291 81.44 10.29 126,052 280,824
2017-07-26 2017-07-24 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10,000 12,250 -44.94
2017-07-26 2017-07-24 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10,000 15,041 -39.93 59.29 -592,900 891,781
2017-07-26 2017-07-24 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10,000 25,041 66.48 10.29 102,900 257,672
2017-07-03 2017-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 253 15,041 1.71 40.66 10,286 611,499
2017-03-06 2017-03-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5,000 22,250 -18.35
2017-03-06 2017-03-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,000 14,788 -25.27 55.00 -275,000 813,340
2017-03-06 2017-03-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,000 19,788 33.81 10.29 51,450 203,619
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -623 14,788 -4.04 46.29 -28,839 684,537
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -512 13,817 -3.57 46.29 -23,701 639,603
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -733 13,018 -5.33 46.29 -33,931 602,603
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -553 11,876 -4.45 46.29 -25,598 549,740
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,594 4,779 -25.01
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,311 2,620 -33.35
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,875 1,875 -50.00
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,415 0 -100.00
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 7,537 7,537
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,594 15,411 11.54
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,311 14,329 10.07
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,875 13,751 15.79
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,415 12,429 12.85
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 45,225 45,225
2017-01-04 2017-01-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 211 11,014 1.95 20.76 4,380 228,618
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -22,805 0 -100.00
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -17,805 10,803 -62.24 38.54 -686,205 416,348
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 17,805 28,608 164.82 11.27 200,662 322,412
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,000 10,803 -31.64 34.08 -170,400 368,166
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,000 15,803 46.28 11.27 56,350 178,100
2016-11-09 2016-11-07 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5,000 22,805 -17.98
2016-11-09 2016-11-07 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,000 10,803 -31.64 34.00 -170,000 367,302
2016-11-09 2016-11-07 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,000 15,803 46.28 11.27 56,350 178,100
2016-07-01 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 213 10,803 2.01 20.76 4,421 224,238
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -522 10,590 -4.70 41.46 -21,640 439,021
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -747 9,801 -7.08 41.46 -30,967 406,305
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -564 8,673 -6.11 41.46 -23,383 359,572
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -277 7,822 -3.42 41.46 -11,484 324,284
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,311 3,931 -25.01
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,875 3,750 -33.33
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,415 1,415 -50.00
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -694 0 -100.00
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 6,373 6,373
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,311 11,112 13.38
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,875 10,548 21.62
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,415 9,237 18.09
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 694 8,099 9.37
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 38,240 38,240
2016-01-04 2016-01-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
J - Other 89 7,405 1.22 47.71 4,246 353,296
2015-12-17 2015-12-16 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -3,909 0 -100.00
2015-12-17 2015-12-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,909 7,316 -34.82 58.85 -230,045 430,547
2015-12-17 2015-12-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,909 11,225 53.43 14.47 56,563 162,426
2015-12-17 2015-12-15 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -4,000 3,909 -50.58
2015-12-17 2015-12-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,000 7,316 -35.35 56.00 -224,000 409,696
2015-12-17 2015-12-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,000 11,316 54.67 14.47 57,880 163,743
2015-11-12 2015-11-10 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5,000 7,909 -38.73
2015-11-12 2015-11-10 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,000 7,316 -40.60 64.00 -320,000 468,224
2015-11-12 2015-11-10 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,000 12,316 68.34 14.47 72,350 178,213
2015-11-09 2015-11-06 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5,000 12,909 -27.92
2015-11-09 2015-11-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,000 7,316 -40.60 56.00 -280,000 409,696
2015-11-09 2015-11-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,000 12,316 68.34 14.47 72,350 178,213
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 87 7,316 1.20 48.59 4,227 355,455
2015-03-25 2015-03-24 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -9,000 17,909 -33.45
2015-03-25 2015-03-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -9,000 7,229 -55.46 71.01 -639,090 513,331
2015-03-25 2015-03-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 9,000 16,229 124.50 14.47 130,230 234,834
2015-03-25 2015-03-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -6,000 26,909 -18.23
2015-03-25 2015-03-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 7,229 -12.15 71.00 -71,000 513,259
2015-03-25 2015-03-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 8,229 13.83 14.47 14,470 119,074
2015-03-25 2015-03-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,000 7,229 -40.89 69.80 -349,020 504,613
2015-03-25 2015-03-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,000 12,229 69.17 14.47 72,350 176,954
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -714 7,229 -8.99 67.96 -48,526 491,312
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -539 6,068 -8.16 67.96 -36,633 412,406
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -265 5,192 -4.86 67.96 -18,010 352,869
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,875 5,625 -25.00
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,415 2,830 -33.33
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -694 694 -50.00
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 5,242 5,242
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,875 7,943 30.90
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,415 6,607 27.25
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 694 5,457 14.57
2015-01-05 2015-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 31,457 31,457
2015-01-05 2015-01-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 136 4,763 2.94 30.05 4,086 143,116
2014-08-28 2014-08-27 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5,000 0 -100.00
2014-08-28 2014-08-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 4,627 -30.18 40.55 -81,100 187,625
2014-08-28 2014-08-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,000 6,627 43.22 15.38 30,760 101,923
2014-08-28 2014-08-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,000 6,627 43.22 15.38 30,760 101,923
2014-08-28 2014-08-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 4,627 -17.77 40.53 -40,530 187,532
2014-08-28 2014-08-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 5,627 21.61 15.38 15,380 86,543
2014-08-28 2014-08-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 4,627 -30.18 40.50 -81,000 187,394
2014-07-01 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 291 4,627 6.71 30.20 8,788 139,738
2014-06-25 2014-06-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -11,200 5,000 -69.14
2014-06-25 2014-06-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,000 4,336 -53.56 36.54 -182,715 158,450
2014-06-25 2014-06-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,000 9,336 115.31 15.38 76,900 143,588
2014-06-25 2014-06-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,200 4,336 -58.85 36.97 -229,195 160,289
2014-06-25 2014-06-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,200 10,536 142.99 15.38 95,356 162,044
2014-01-17 2014-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -265 4,336 -5.76 47.08 -12,476 204,143
2014-01-17 2014-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -539 3,906 -12.13 47.08 -25,377 183,899
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -695 1,388 -33.37
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,415 4,245 -25.00
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 7,500 7,500
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 695 4,601 17.79
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,415 4,445 46.70
2014-01-03 2014-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 45,000 45,000
2014-01-03 2014-01-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 164 3,030 5.72 24.20 3,969 73,324
2013-12-06 2013-12-05 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10,000 16,200 -38.17
2013-12-06 2013-12-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,550 2,866 -61.35 39.90 -181,545 114,353
2013-12-06 2013-12-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,550 7,416 158.76 15.38 69,979 114,058
2013-12-06 2013-12-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,640 2,866 -55.95 39.94 -145,382 114,468
2013-12-06 2013-12-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,640 6,506 127.01 15.38 55,983 100,062
2013-12-06 2013-12-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,810 2,866 -38.71 39.92 -72,255 114,411
2013-12-06 2013-12-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,810 4,676 63.15 15.38 27,838 71,917
2013-09-23 2013-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10,000 26,200 -27.62
2013-09-23 2013-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10,000 2,866 -77.72 35.02 -350,200 100,367
2013-09-23 2013-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10,000 12,866 348.92 15.38 153,800 197,879
2013-09-11 2013-09-09 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10,000 36,200 -21.65
2013-09-11 2013-09-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10,000 2,866 -77.72 30.22 -302,250 86,625
2013-09-11 2013-09-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10,000 12,866 348.92 15.38 153,800 197,879
2013-07-03 2013-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 756 2,866 35.83 9.20 6,953 26,359
2013-05-02 2013-05-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -6,145 0 -100.00
2013-05-02 2013-05-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -23,800 0 -100.00
2013-05-02 2013-05-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,145 2,110 -74.44 22.26 -136,794 46,971
2013-05-02 2013-05-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,145 8,255 291.23 11.12 68,332 91,796
2013-05-02 2013-05-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -23,800 2,110 -91.86 22.26 -529,812 46,971
2013-05-02 2013-05-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 23,800 25,910 1,127.96 6.81 162,078 176,447
2013-05-02 2013-04-30 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -30,000 6,145 -83.00
2013-05-02 2013-04-30 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -30,000 2,110 -93.43 22.51 -675,153 47,486
2013-05-02 2013-04-30 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 30,000 32,110 1,421.80 11.12 333,600 357,063
2013-02-01 2013-01-30 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 34,000 34,000
2013-02-01 2013-01-30 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 5,660 5,660
2013-01-17 2013-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -309 2,110 -12.77 14.00 -4,326 29,540
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -695 2,083 -25.02
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 695 2,419 40.31
2013-01-03 2013-01-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 447 1,724 35.00 8.87 3,967 15,299
2012-07-11 2012-07-09 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5,000 23,800 -17.36
2012-07-11 2012-07-09 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5,500 0 -100.00
2012-07-11 2012-07-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,000 1,277 -79.66 13.51 -67,550 17,252
2012-07-11 2012-07-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,000 6,277 391.54 6.81 34,050 42,746
2012-07-11 2012-07-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5,500 1,277 -81.16 13.51 -74,305 17,252
2012-07-11 2012-07-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5,500 6,777 430.70 6.84 37,620 46,355
2012-07-03 2012-07-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -6,000 5,500 -52.17
2012-07-03 2012-07-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,000 1,277 -82.45 12.91 -77,460 16,486
2012-07-03 2012-07-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,000 7,277 469.85 6.84 41,040 49,775
2012-07-03 2012-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 648 1,277 103.02 6.13 3,971 7,826
2012-03-07 2012-01-03 4/A ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 25,013 25,013
2012-03-07 2012-01-01 4/A ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 324 629 106.23 6.13 1,986 3,855
2012-01-17 2012-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2,778 2,778
2012-01-03 2012-01-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 25,013 25,013
2012-01-03 2011-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 324 629 106.23 6.13 1,986 3,855
2010-01-05 2010-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 27,805 27,805
2010-01-05 2010-01-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 195 1,171 19.98 9.44 1,841 11,058
2004-07-02 2004-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
J - Other 295 858 52.40 4.86 1,434 4,172
P
Open market or private purchase of non-derivative or derivative security
S
Open market or private sale of non-derivative or derivative security
A
Grant, award, or other acquisition of securities from the company (such as an option)
C
Conversion of derivative
D
Sale or transfer of securities back to the company
F
Payment of exercise price or tax liability using portion of securities received from the company
G
Gift of securities by or to the insider
K
Equity swaps and similar hedging transactions
M
Exercise or conversion of derivative security received from the company (such as an option)
V
A transaction voluntarily reported on Form 4
J
Other (accompanied by a footnote describing the transaction)